The scientific advisor for Operation Warp Speed floated the idea today of cutting the Moderna doses in half, from two 100 microgram doses to two 50 microgram doses. 1/n nytimes.com/live/2021/01/0…
It appears that he’s relying on Phase 2 trial results, in which 200 people under 55 got 50 micrograms of Moderna and had comparable antibody responses to people who got 100 micrograms. 2/n
That assumes that antibody levels are a correlate of protection. There’s data from monkeys that this *might* be true, but nothing yet from people that I’ve seen. nytimes.com/2020/12/04/hea… 3/n
And there’s the 200 people who got 50 micrograms in the Phase 2 study. After running a 30,000-person Phase 3 trial, that’s a pretty small hook to hang one’s hat on.
Moderna didn’t reply to @KatherineJWu right away, so we’ll see what they say. /end
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