“My concern, as a virologist, is that if you wanted to make a vaccine-resistant strain, what you would do is to build a cohort of partially immunized individuals in the teeth of a highly prevalent viral infection” statnews.com/2021/01/04/bri…
Another virologist with similar concerns:
https://twitter.com/angie_rasmussen/status/1346830624108077056?s=20
These are certainly not the only perspectives. Many are also arguing that we're already in a massive immune escape experiment, with immune responses waning and new mutations like E484K displaying dominance and mAbs escape potential.
In the U.S. discussions of changing the dose regiment may be viewed as an easy out, replacing actions like stringent lockdowns. But, in the U.K., the view may lean to it being the only answer as mitigations aren't succeeding. It's a complex discussion.
https://twitter.com/chrischirp/status/1345834339527962631?s=20
And of course, what is happening in the U.K. right now will happen in the U.S. within months — unless our rollout can accelerate beyond all projections, or a proactive immunization pivot alters any supply constraints.
What really sucks is that no one seems to be studying these regiment changes. If the world could collect U.K. data within weeks, it would better inform global rollouts. Instead, everyone is on the verge of running their own experiment with little cooperation.
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