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Daniel Sinclair Profile picture
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5 Jan, 5 tweets, 2 min read
I expected a show, but it looks like we won’t even get that. The cover-up continues.
I wonder how much this AP report has played into Beijing’s decision to renege on the WHO investigation agreement. apnews.com/article/united…
"The lines of communication have broken down.” wsj.com/articles/world…
Friend and colleague of Shi Zhengli sharing the news:
As if it wasn’t already clear: “Delays to a long-planned mission by WHO experts to China to investigate the origins of the Covid-19 pandemic are ‘not just a visa issue’, Beijing said Wednesday.” news.yahoo.com/china-says-del…

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More from @_DanielSinclair

Daniel Sinclair Profile picture
6 Jan
Things are heating up in D.C. 👀
Capitol buildings are already being evacuated:
Meanwhile:
Read 202 tweets
Daniel Sinclair Profile picture
5 Jan
Uh oh: “The most important site is E484, where neutralization by some sera is reduced >10-fold by several mutations, including one in emerging viral lineages in South Africa and Brazil.”
The South African variant has both E484K and N501Y, so the concerns from the last few weeks are more justified now. What will the combination of the higher viral loads associated with N501Y — if that holds — mean when neutralization dips because of E484K escape? Not liking this.
We’re already seeing that experiment play out in South Africa. We’ll know more about vaccine efficacy soon, but I imagine the first immune escape alarm would be a rise in re-infections among those exposed to prior lineages. We shouldn’t wait around for that data...
Read 5 tweets
Daniel Sinclair Profile picture
4 Jan
The underlying tone of this is irresponsible. This is not journalism; this is a collection of anecdotes with a preconceived narrative. nymag.com/intelligencer/…
That Quibi screenplay really cherry picks details, like the leaked Hubei CDC reports that suggest the first epidemic may not have occurred in Wuhan after all. The Yichang or Xianning 'influenza' epidemics could have been wrongfully attributed cnn.com/2020/11/30/asi…
At the end of the day, so much of this easily weaponized mystique results directly from the Communist Party's narrative, cover up, and censorship. This is a story about the Chinese system, not about a virology lab and gain functions.
Read 7 tweets
Daniel Sinclair Profile picture
4 Jan
“My concern, as a virologist, is that if you wanted to make a vaccine-resistant strain, what you would do is to build a cohort of partially immunized individuals in the teeth of a highly prevalent viral infection” statnews.com/2021/01/04/bri…
Another virologist with similar concerns:
These are certainly not the only perspectives. Many are also arguing that we're already in a massive immune escape experiment, with immune responses waning and new mutations like E484K displaying dominance and mAbs escape potential.
Read 6 tweets
Daniel Sinclair Profile picture
4 Jan
The warning Wuhan never gave us. Why don't we care?
The message that is still not being clearly articulated is that the mitigations that have worked may no longer work under B.1.1.7 and B.1.351. Our mitigations until now have been based on the Wuhan and Lombardy data; now we have no clue what will happen.
We've been like "well, we know that works, & we'd do it if only it was easier"

Now we're at "what the hell is going to happen here" with London looking like this despite lockdowns 📈
Read 8 tweets
Daniel Sinclair Profile picture
23 Sep 20
This type of coordinated behavior was quickly substantiated following Christchurch. I haven't seen much evidence of that here. If Discord edgelords are a 'dark web' 'coordinated attack' than TikTok might not be equipped to combat the PRC actors.
I don't expect every platform to succeed against this type of thing, but ByteDance literally prepared for this exact scenario — and they simply failed. Maybe they should own up to that instead of describing it like organized cybercrime and nation states.
"We learned that groups operating on the dark web made plans to raid social media platforms, including TikTok, in order to spread the video across the internet" theguardian.com/technology/202…
Read 6 tweets

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