President-elect Biden has set a goal of vaccinating 100 million Americans (30% of the population) in 100 days.

It is an ambitious, achievable goal.

Here is what that will require, via @JenniferNuzzo, Sid Baccam @IEMNews, and me in the @nytimes 1/
nytimes.com/2021/01/20/opi…
Primary constraint on vaccinating more Americans so far has not been supply

Despite production shortfalls, US still distributed close to enough doses to vaccinate average of 1M people daily

Bigger hurdles have been administration & demand 2/
covid.cdc.gov/covid-data-tra…
Reaching 1 million people per day requires expanding beyond vaccinating small number of individuals on scheduled-basis to doing more mass vaccination

After 9/11, federal gov't thought through how to vaccinate many Americans in a short time 3/
liebertpub.com/doi/pdf/10.108…
Leveraging those plans, here's our estimate of what we think will be required to vaccinate average of 1M people per day for 100 days

- at least 400 vaccination sites

- 100k-184k staff, incl. at least 17k qualified vaccinators

- working 12 hrs/day

- 120-220 workers per shift
These numbers are just a start.

The point is that vaccinating 1M/per day for 100 days will require extensive and costly intervention from federal gov't.

The qualified personnel required to conduct vaccination at this scale simply don’t exist within public health departments 5/
Then there's the problem of demand

Mass vaccination plans generally assume population wants to be vaccinated

Reports of health care workers refusing COVID vaccinations are worrisome.

State and local govts must bolster their engagement with community groups to address concerns
Increasing the volume of vaccinations should not come at the expense of getting doses into the arms of the people most at risk from #COVID19

Here is how we think those goals can be balanced 7/

nytimes.com/2021/01/20/opi…
I think this important piece by @DrLeanaWen has good ideas on this too and is worth your time 8/
washingtonpost.com/opinions/2021/…
State, local & tribal authorities need more resources to dispense vaccines to every American who wants one

President-elect plan has $20 billion for vaccination & requests funding to hire 100,000 health workers

It's money well spent in a pandemic. Congress should authorize it
Reaching 100 million people in 100 days would be the most ambitious vaccination campaign in U.S. history.

It needs support that will be equal to the task.

You can read rest from @JenniferNuzzo, @JenniferNuzzo, Sid Baccam @IEMNews, and me here:

10/10
nytimes.com/2021/01/20/opi…

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More from @TomBollyky

30 Dec 20
Good news! Vaccine is relatively cheap, easy to produce & store, well tolerated. 3B doses projected in 2021

Haven't seen submission or decision, but MHRA reportedly approved 2 dose regimen (62% effective) & is encouraging a 1-dose regimen to speed access
Results published in Lancet indicate say this a/b 1 dose regimen

It will be interesting to see public response and distribution strategy for regimen w/lower efficacy than Pfizer/Moderna options & uncertainty about duration of protection
thelancet.com/journals/lance…
Apparently, Oxford/AstraZeneca has not even filed a submission package with EMA yet. FDA decision isn't coming soon either.

This is such an important vaccine for global access and so much is strange about how its sponsors have pursued it
reuters.com/article/us-hea…
Read 4 tweets
29 Dec 20
Revolutions often go full circle, recreating circumstances that led to initial upheaval

For 2d time in 20 yrs world faces a treatment access crisis

1st crisis transformed #globalhealth but laid seeds for latest crisis over vaccines

My latest w/@ChadBown
foreignaffairs.com/articles/world…
20 yrs ago, crisis over AIDS drugs brought deep & lasting changes, pumping $$ into R&D of new meds & creating new institutions to deliver them

But it also shifted focus of #globalhealth 2/

foreignaffairs.com/articles/world…
Global health became less a/b cooperation among nations on common threats and more a/b aid-driven initiatives and public-private partnerships to solve the problems of *other* people—mostly in low-income countries 3/
Read 7 tweets
14 Nov 20
Interim results on Pfizer vaccine are promising

But getting safe doses to those who would benefit most depends on reversing a trend that has defined this pandemic:

to quote Isaac Asimov, “science gathers knowledge faster than society gathers wisdom” 1/
theatlantic.com/ideas/archive/…
US #COVID19 hospitalizations & deaths are surging, and projections are ~200,000 more Americans will lose their lives to the virus before March

A safe vaccine could help shift that trajectory but only if we learn from past US failures distributing vaccines to adults 2/
According to recent analysis, 75% Americans would need to receive a vaccine that prevents at least 80% of infections for that vaccine to end #COVID19 pandemic on its own

(h/t @PeterHotez) 3/
ajpmonline.org/article/S0749-…
Read 16 tweets
23 Oct 20
Countries without government trust have performed badly in #COVID19, even when you account for differences in population age and size, and the timing of the pandemic

New analysis in @ForeignAffairs via @samckiernan, Sawyer Crosby @IHME_UW, and me 1/
foreignaffairs.com/articles/unite…
“Government exists to protect us from each other,” Reagan once said, but goes “beyond its limits . . . in deciding to protect us from ourselves”

When applied to pandemics, Reagan was wrong & so are policymakers, in esp. in US, who have adopted this view
foreignaffairs.com/articles/unite…
Confronted w/novel contagious virus, for which there's no effective treatment & no preexisting immunity, the only way to protect citizens from one another is by convincing them to protect themselves

Esp. in free societies that depends on trust between government and its people
Read 15 tweets
23 Oct 20
The most important lessons from #COVID19 are less about virus itself but what it has revealed about the political systems that have responded to it

@IlonaKickbusch & I were thrilled to guest edit a @bmj_latest series on preparing democracies for pandemics
bmj.com/democracy-and-…
The @bmj_latest series examines the mechanisms that might explain underperformance of democracies in #COVID19 crisis and proposes ideas to better “pandemic proof” this political system

The articles in series includes: 2/8
bmj.com/democracy-and-…
A commentary from @IlonaKickbusch & me on preparing democracies for pandemics 3/8:

bmj.com/content/371/bm…
Read 6 tweets
1 Oct 20
The U.S. 'early' travel ban wasn't early, it wasn't a ban, and it wasn't effective

Worse still, the widespread use of travel bans by US & others have made us less safe.

New in @washingtonpost on from @JenniferNuzzo & me 1/

washingtonpost.com/outlook/2020/1…
1. The US wasn't early

45 other countries implemented travel restrictions against China before US did on Feb. 2

At that point, US & 20+ other countries had already reported #COVID19 cases. Several were even reporting local transmission of cases 2/

thinkglobalhealth.org/article/travel…
Between the first official report of outbreak in China & announcement of U.S. travel restrictions, 40,000+ travelers from China are estimated to have entered United States 3/

nytimes.com/2020/04/04/us/…
Read 13 tweets

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