1/n
💊How to best combine targeted agents with #radiotherapy☢️
Ch4⃣from our book
springer.com/us/book/978303…
Biomarkers of clinical radioresistance. Great pleasure to have written this one with @max_diehn @michaelsbinkley Iris Eke @StanfordRadOnc🙏
#radonc #radbio #RTdrugcombo
💊How to best combine targeted agents with #radiotherapy☢️
Ch4⃣from our book
springer.com/us/book/978303…
Biomarkers of clinical radioresistance. Great pleasure to have written this one with @max_diehn @michaelsbinkley Iris Eke @StanfordRadOnc🙏
#radonc #radbio #RTdrugcombo
2/n
As @SorenBentzen keeps saying, absolute radioresistance does not exist. You just have to up the dose💪
That is very different from drug response, which is a yes/no situation - where more drug does not give you typically a better response (with caveats 😉)
#radonc #radbio
As @SorenBentzen keeps saying, absolute radioresistance does not exist. You just have to up the dose💪
That is very different from drug response, which is a yes/no situation - where more drug does not give you typically a better response (with caveats 😉)
#radonc #radbio
3/n
Tumors can have variable radioresistance. Lab & human data indicate that relationship between dose + tumor eradication is sigmoid🚨
Really high doses are prohibited by tolerance of normal tissue surrounding the tumor‼️
= Rationale for pursuing targeted radiosensitizers💡
Tumors can have variable radioresistance. Lab & human data indicate that relationship between dose + tumor eradication is sigmoid🚨
Really high doses are prohibited by tolerance of normal tissue surrounding the tumor‼️
= Rationale for pursuing targeted radiosensitizers💡
4/n
Still poorly studied: What is the nature of the #cancer stem cells (= clonogenic cells) that #radiotherapy needs to eliminate to prevent tumor regrowth❓
Only 1 surviving stem cell can repopulate the tumor!
Treatment should be stem cell specific!
#radbio #researchmatters
Still poorly studied: What is the nature of the #cancer stem cells (= clonogenic cells) that #radiotherapy needs to eliminate to prevent tumor regrowth❓
Only 1 surviving stem cell can repopulate the tumor!
Treatment should be stem cell specific!
#radbio #researchmatters
5/n
In the clinic today, what is the most important marker of radioresistance that #radonc clinicians should factor into their treatment decisions?
@rweichselbaum @Hammond_Lab @jtorresroca @_MichaelBaumann @sophia_kamran
In the clinic today, what is the most important marker of radioresistance that #radonc clinicians should factor into their treatment decisions?
@rweichselbaum @Hammond_Lab @jtorresroca @_MichaelBaumann @sophia_kamran
6/6
Next week, part 2 of this chapter. Diving into some of our favorite tumor genes (KEAP1 KRAS TP53) and discussing importance of tumor size vs genotype 😉
@max_diehn @michaelsbinkley 🙏🙏🙏
Next week, part 2 of this chapter. Diving into some of our favorite tumor genes (KEAP1 KRAS TP53) and discussing importance of tumor size vs genotype 😉
@max_diehn @michaelsbinkley 🙏🙏🙏
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