For the first time ever—French drugmaker Sanofi helps a rival—agrees to produce >125 million doses of BioNTech and Pfizer's #COVID19 vaccine for the EU. It will lend its production facilities in a highly unusual collaboration.

Wow, quite a gesture.
bloomberg.com/news/articles/…
2) The French drugmaker will give BioNTech access to a production facility in Frankfurt, which will start to deliver doses this summer, Sanofi said in a statement Wednesday. Sanofi also did this because their own vaccine hit snafu and won’t be ready anytime soon.
3) Let this sink - France is home to the famed Louis Pasteur institute - what @spignal calls the “spiritual home” of vaccines.

Lots of wounded French 🇫🇷 egos for sure, but glad they were big enough to do this and help the world.
4) Famed french @TheEconomist journalist @spignal goes further — the French think is “seen as symbol of France 🇫🇷 losing ground in global race for knowledge/science”

And he points out many in France had said there’s “no chance of a vaccine within a year, likely 4 years”.
5) French egos aside, why isn’t more pharma companies doing this to collaborate? Why can we just share resources to combat pandemic.

If there is an asteroid ☄️ coming to hit 🌍, we would collaborate. Why can’t we do this for #COVID19 vaccine production?
6) Before we clap for @sanofi too much... they also just fired 400 research scientists.

And they did this AFTER paying a massive dividend to its stock shareholders. sudouest.fr/2021/01/26/san…
7) That said, I admire the graciousness of @sanofi to make another drug maker’s vaccine. But please hire back the 400 researchers you fired @sanofipasteur.

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More from @DrEricDing

29 Jan
Scoop:💡NEW VACCINE APPOINTMENT SEARCH ENGINE💡

Vaccines save lives, but process of booking a Walgreens slot online is a “hellish experience”.

Wasted slots = longer #COVID19 pandemic.

➡️ Solution: Hackivists created a fast & easy live search engine!!!🧵
getmyvaccine.org Image
2) Nationwide, Walgreens & Duane Reed vaccine booking system sucks, says @erick_hietamaki.

On Walgreen’s sucky website, you have to pick an exact Walgreens (and only one at a time), and then pick exact date (only that date) and then a time window (only that window!!!)—ugly. Image
3) And if searching different SPECIFIC time window or date or store, you have to start all over again on Walgreens—most cumbersome site ever! if you’re not tech savvy, forget it!

Also, what if you want to check last minute openings & want to quick check for new slots?! Tough... Image
Read 9 tweets
28 Jan
BREAKING—Novavax says its #COVID19 vaccine is 90% effective, but likely only 50% against the #B1351 variant found in South Africa.

50% better than 0%, but clearly we have challenges with the #B1351 mutation. UPDATES COMING.
nytimes.com/2021/01/28/hea…
2) SURPRISING—“Participants were infected with the variant even after they had already had Covid.” This aligns with what South Africa CDC warned last week
3) “we are the first to conduct an efficacy trial — in the face of a changing virus,” said Stanley Erck, CEO of Novavax. He said that researchers expected variants could change the trial results, but “the amount of change has been a bit of a surprise to everyone.”
Read 14 tweets
28 Jan
BREAKING—First two community transmission cases of the worrisome #SARSCoV2 strain #B1351 first seen in South Africa 🇿🇦 have been detected in South Carolina. No travel history in either cases. #B1352 is the one seen to evade antibodies. #COVID19
cnn.com/2021/01/28/hea…
2) The variant -- also known as B.1.351 -- has raised concerns over being more transmissible than other versions of the virus, and potentially evading the immune protection offered by antibodies. Experts say they believe vaccines will still be effective against the variant.
3) "The arrival of the SARS-CoV-2 variant in our state is an important reminder to all South Carolinians that the fight against this deadly virus is far from over," Dr. Brannon Traxler, the health department's interim public health director, said in a statement Thursday.
Read 4 tweets
28 Jan
My god—frontline immigrant healthcare workers in hospitals in U.K. who don’t have an NHS health number are being DENIED #COVID19 vaccines by 🇬🇧 government. They treat COVID patients daily!!!

Boris Johnson is like the Donald Trump of the U.K.
2) yes they are similar. newstatesman.com/politics/uk/20…
3) 'They call him Britain Trump' bbc.co.uk/news/world-us-…
Read 4 tweets
28 Jan
Does neuroinvasion of the brain by #SARSCoV2 happen? Not just in mice, but in *humans*? The clear answer in this study is yes — both demonstrated with human brain cells and brain 🧠 inspection of deceased #COVID19 patients. 🧵 from a peer reviewed paper.
ncbi.nlm.nih.gov/pmc/articles/P… Image
2) Let’s first read the abstract:

📌”using human brain organoids... clear evidence of infection”

📌”neuroinvasion can be blocked”

📌”in autopsies of patients who died of COVID19... we detect #SARSCoV2 in neurons”

📌”neuroinvasive capacity of #SARSCoV2Image
3) Conclusions from main discussion summary:

📌”results suggest that neurological symptoms associated with COVID-19 may be related to consequences of direct viral invasion of the central nervous system”

📌”brain is a site for high replicative potential for SARS-CoV-2.” Image
Read 13 tweets
28 Jan
WORRISOME MATH—#B117 variant is so crazy: what happens if there are just 10 cases now, & new 🇬🇧 #B117 has 50%⬆️ transmissibility?

📌1000+ daily cases on Mar23

📌2000+ daily cases on Mar31

This doesn’t include schools reopening or vaccines.

(HT @GosiaGasperoPhD) #COVID19 Image
2) Notably, the virus is such a beast—suppose we have 1000 cases/day now... with an R=0.86 we could reduce it to 500/day in 2 weeks.

➡️But w/ added contagiousness of B117 variant that has ~60% higher R, in 2 weeks, we’d have 3000 new cases/day—3x! 6x vs old

HT @GosiaGasperoPhD Image
3) Denmark 🇩🇰 CDC has modeled this as well... and it’s horrendous. Denmark sequences EVERY SINGLE CASE EACH WEEK for mutations and they know it’s increasing 70% per week!!! Earlier modeling:
Read 13 tweets

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