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❄️ Mac n’ Chise ❄️ Profile picture
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4 Feb, 8 tweets, 2 min read
Guys. Guess what.

I’m getting vaccinated tomorrow!
Today is THE day! Let’s do this! Appointment is at 9:15- I’m ready! Thank you guys so much for all the support. I’ll definitely document everything for you guys as promised. ♥️
AND one step closer to being protected against COVID! 1st Moderna vaccine was a success! In all honesty, as a person who has a phobia of needles, I think that was the EASIEST shot I have ever had. I barely felt it. It stings ever so slightly but otherwise I am feeling fantastic. Image
I think it just hit me. How surreal this is. I just took my own vaccine. Wow.
Good morning. This is me.
Ok, I’m kidding! Not by much. Yes, my arm is a little sore today- I expected that. I’m a little sore all over but at least I know my immune system is hard at work! I highly recommend having a pain reliever on board- they do wonders right now.
So slight fever of 100.4 and some chills. I’m at a little over 24 hours. I have been craving orange juice for some strange reason and have just been resting easy with a warm blanket and some reading material. Feels like a mild flu at this point.
Also yes, I promise I am resting. As much as my brain will let me. I have to share good news when I’m reading. And thank you @andrew_croxford for reminding me about that encouraging study. Reminder, you CAN take pain relievers after your vaccine. It’s before it you shouldn’t.
Temperature has gone down a little. Teetering on 99.8. Hot showers and Aleve (Naproxen Sodium) seem to be doing the trick and helping. Well, that and orange juice. Body aches are still there but very manageable. Feels like I just had a heavy workout yesterday.

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More from @sailorrooscout

❄️ Mac n’ Chise ❄️ Profile picture
7 Feb
It is important to point out that the Oxford/AstraZeneca vaccine is effective against the B.1.1.7 variant and reduces virus shedding and transmission. With this most likely being the dominate strain, this means their current vaccines are still effective as they update boosters.
From what we have seen, it is evident that B.1.1.7 (UK) is inherently more transmissible when compared to the original strain ( by ~50%), and it may be right to assume when populations are exposed to this variant, it’ll likely become the dominant strain relatively quickly.
We are seeing this happen in many areas. Hear me out. In a sense, this actually works to our advantage as we witness this selective pressure occur. B.1.1.7 may be essentially allowing us time to administer booster vaccinations against this variant and it’s newly added E484K.
Read 9 tweets
❄️ Mac n’ Chise ❄️ Profile picture
6 Feb
Please stop this. You conveniently fail to point out NONE of the MORE than 2,000 patients in this study died or was hospitalized. THIS matters. The purpose of vaccination is to bring the severity down to the level of a benign virus. That’s how this works. Report it correctly.
I’d like to mention this article doesn’t possess any numbers or data either. Please understand, the AZN vaccine may not prevent mild to moderate COVID. So you might face something similar to a flu if you happen to get infected after vaccination. It’s better than the alternative.
ALSO it is a KNOWN fact AstraZeneca/Oxford is currently working on a booster to increase efficacy against the B.1.351 variant. News flash: EVERY single vaccine is, not just this one. Let’s stop this. What you need to know is it is going to help you avoid the hospital and worse.
Read 6 tweets
❄️ Mac n’ Chise ❄️ Profile picture
3 Feb
Vaccines are preventives, not cures.

The purpose of vaccination is to bring the severity down to the level of a benign virus. That’s how this works. In the face of variants, our best protection against the convergent evolution we are witnessing is to get more people vaccinated,
and get infection levels down to a manageable amount. Masks, social distancing measures, testing, tracing, and sufficient lockdowns. It works. We have seen it. Witness other countries who are on their way to establishing some normalcy. It’s not impossible.
Now with that said, all of the vaccines available thus far have proven to be 100% effective at preventing severe cases of COVID, hospitalization, and death. This is what matters. Even in the face of these variants. What I need everyone to stop doing is torturing themselves by
Read 12 tweets
❄️ Mac n’ Chise ❄️ Profile picture
2 Feb
Some REALLY promising results coming out of Oxford/AstraZeneca. After one dose of their vaccine after 22 days: 76% efficacy against symptomatic COVID and 100% effective at preventing hospitalizations. After two doses: 54% reduction in transmission.
papers.ssrn.com/sol3/papers.cf…
Make no mistake, reduction is transmission is a GAME CHANGER. Not to mention, antibody response appears to be more robust after longer interval between their doses. This presents data to justify safely delaying doses if and when vaccines are in short supply. It’s quite a relief.
Also before you scoff at that 54% let me remind you we don’t even have enough data to establish that our mRNA vaccines prevent transmission yet, okay? Remember what I told you guys, 100% effective at preventing death, severe cases, and hospitalizations is VITAL and that matters.
Read 6 tweets
❄️ Mac n’ Chise ❄️ Profile picture
2 Feb
Concerning the SARS-CoV-2 variants that were first identified in the UK (B.1.1.7), South Africa (B.1.351), and Brazil (P.1), their specific mutations focus on altering the fitness of the virus by improving its rate of transmission but with mild signs of immune evasion. A thread.
From what we have seen, it is evident that B.1.1.7 (UK strain) is inherently more transmissible when compared to the original strain ( by ~50%), and it may be right to assume when populations are exposed to this variant, it’ll likely become the dominant strain relatively quickly.
While B.1.351 and P.1 are independent lineages, they have several key mutations in common being (see my screens for descriptions of the mutations of concern we targeted with our vaccines) D416G, K417N/T, E484K, and N501Y (whereas N501Y, D416G, and E484K are shared with B.1.1.7).
Read 14 tweets
❄️ Mac n’ Chise ❄️ Profile picture
1 Feb
Okay, while this sounds alarming, I am here to tell you this is to be expected. Viruses undergo evolution and natural selection, just like cell-based life, and most of them evolve rapidly. The E484K mutation was already identified in the SA and Brazil variant, now the UK variant.
When two viruses infect a cell at the same time, they may swap genetic material to make new, "mixed" viruses with unique properties. For example, influenza strains can arise this way. Natural selection can only happen when it has the right starting material: genetic variation.
Genetic variation means there are some genetic (heritable) differences in a population. In viruses, variation comes from either recombination where viruses swap chunks of genetic material (DNA or RNA) or random mutation where a change occurs in the DNA or RNA sequence of a virus.
Read 7 tweets

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