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❄️ Mac n’ Chise ❄️ Profile picture
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8 Feb, 7 tweets, 2 min read
Something we have been waiting for. Concerning Pfizer’s vaccine, results show key mutations N501Y, 69/70-deletion, D614G, and E484K from variant B.1.1.7 and B.1.351 have little effect on neutralization by sera elicited by two doses of the vaccine.
nature.com/articles/s4159…
The neutralization GMT of the serum panel against the virus with three mutations from B.1.351 (E484K + N501Y + D614G) was slightly lower than the neutralization GMTs against the N501Y virus or the virus with three mutations from the UK variant (Δ69/70 + N501Y + D614G). However,
differences in neutralization GMTs against any of the mutant viruses in this study was small (0.81- to 1.41-fold) as compared to the greater than four-fold differences that have been used to signal potential need for a strain change in influenza vaccines.
In short, B.1.351, B.1.1.7 and their respective mutations have little effect on the efficacy of Pfizer’s vaccine. This is very good news for us.
More good news. Data out of Israel may answer the question to if these Coronavirus vaccines can reduce transmission. Below shows reduced viral loads 12 days following Pfizer’s vaccine. Ct values can demonstrate a distinct reduction in viral load. Preprint is expected later.
And here is the preprint!
medrxiv.org/content/10.110… and an additional from another lab reporting similar findings medrxiv.org/content/10.110… Remember decreased viral load is a good thing. It helps us measure disease severity.
To update on this: Over the last 30 days - 1,536 people have died (of COVID-19) in the State of Israel. More than 97% of them had not been vaccinated and FEWER than 3% had been vaccinated.
reuters.com/article/us-hea…

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❄️ Mac n’ Chise ❄️ Profile picture
8 Feb
Let’s talk about immunity and why it’s important to take certain factors into consideration when we look at these studies and maybe why the most recent one on AstraZeneca’s effectiveness on the B.1.351 is a tad bit bothersome. For starters this beauty wasn’t tweeted initially. Image
See that last bullet point? The one of T-cell immunity. Yeah, that’s vital. Why? The study failed to discuss this aspect. You cannot disregard T-cells in the same breath you are discussing B-cells, vaccines and their respective induced antibody responses. It’s a package deal.
T-cells help protect against severe disease. Their analysis shows 76 out of 87 TCB sites (87%) are NOT impacted by the mutations seen in B.1.351. What does this mean? It means the T-cell response generated by AstraZeneca’s vaccine should be highly effective against this variant.
Read 13 tweets
❄️ Mac n’ Chise ❄️ Profile picture
7 Feb
Per Fauci, “When we get into March, April, and May, there will be a substantial number of people vaccinated. So, when we get into the summer, we likely will be doing things that we maybe were not able to do at a time when there was the 300,000 and 400,000 new infections a day."
You know what this means right? When the time comes please get vaccinated. More vaccines are getting approved which allows for improved vaccine allocation efforts. With the B.1.1.7 becoming the dominant strain in a several areas around the globe, this is good news for us as we
know all these vaccines sufficiently protect against this variant even with the E484K mutation. This gives us time to update against the B.1.351 variant as it attempts to increase its fitness. We could easily be looking towards some normalcy by late this year. Let’s keep going.
Read 4 tweets
❄️ Mac n’ Chise ❄️ Profile picture
7 Feb
It is important to point out that the Oxford/AstraZeneca vaccine is effective against the B.1.1.7 variant and reduces virus shedding and transmission. With this most likely being the dominate strain, this means their current vaccines are still effective as they update boosters.
From what we have seen, it is evident that B.1.1.7 (UK) is inherently more transmissible when compared to the original strain ( by ~50%), and it may be right to assume when populations are exposed to this variant, it’ll likely become the dominant strain relatively quickly.
We are seeing this happen in many areas. Hear me out. In a sense, this actually works to our advantage as we witness this selective pressure occur. B.1.1.7 may be essentially allowing us time to administer booster vaccinations against this variant and it’s newly added E484K.
Read 14 tweets
❄️ Mac n’ Chise ❄️ Profile picture
6 Feb
Please stop this. You conveniently fail to point out NONE of the MORE than 2,000 patients in this study died or was hospitalized. THIS matters. The purpose of vaccination is to bring the severity down to the level of a benign virus. That’s how this works. Report it correctly.
I’d like to mention this article doesn’t possess any numbers or data either. Please understand, the AZN vaccine may not prevent mild to moderate COVID. So you might face something similar to a flu if you happen to get infected after vaccination. It’s better than the alternative.
ALSO it is a KNOWN fact AstraZeneca/Oxford is currently working on a booster to increase efficacy against the B.1.351 variant. News flash: EVERY single vaccine is, not just this one. Let’s stop this. What you need to know is it is going to help you avoid the hospital and worse.
Read 6 tweets
❄️ Mac n’ Chise ❄️ Profile picture
4 Feb
Guys. Guess what.

I’m getting vaccinated tomorrow!
Today is THE day! Let’s do this! Appointment is at 9:15- I’m ready! Thank you guys so much for all the support. I’ll definitely document everything for you guys as promised. ♥️
AND one step closer to being protected against COVID! 1st Moderna vaccine was a success! In all honesty, as a person who has a phobia of needles, I think that was the EASIEST shot I have ever had. I barely felt it. It stings ever so slightly but otherwise I am feeling fantastic. Image
Read 8 tweets
❄️ Mac n’ Chise ❄️ Profile picture
3 Feb
Vaccines are preventives, not cures.

The purpose of vaccination is to bring the severity down to the level of a benign virus. That’s how this works. In the face of variants, our best protection against the convergent evolution we are witnessing is to get more people vaccinated,
and get infection levels down to a manageable amount. Masks, social distancing measures, testing, tracing, and sufficient lockdowns. It works. We have seen it. Witness other countries who are on their way to establishing some normalcy. It’s not impossible.
Now with that said, all of the vaccines available thus far have proven to be 100% effective at preventing severe cases of COVID, hospitalization, and death. This is what matters. Even in the face of these variants. What I need everyone to stop doing is torturing themselves by
Read 12 tweets

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