THREAD ON UK VACCINATION PROGRAMME:

TLDR: At 3 mill doses/week expect a big slowdown in *first* doses in April/May. But then summer ramp up to vaccinate all adults by early September.

Increasing to *6 mill/wk* for *6 wks* in April/May could vax everyone by mid July. 1/6
This is where we are now (latest weekly data to 7 Feb). Almost all vaccinations are first dose now.

Vaccination numbers levelling out at about 3 million a week.

But in early March we need to start giving 2nd doses... 2/6
*If* we stay at 3 mill/wk doses, by May ALL those 3 mill doses will be spent giving 2nd doses to people vaccinated in Feb.

In June 1st dose ramps up again & all adults offered 1st dose by end July. Using 3 mill/wk for 2nd doses means all offered 2 doses by early Sept

BUT 3/6
IF we ramp up supply & capacity to deliver 6 mill/wk doses by mid April for *6 weeks* then we can *keep* vaccinating new people at 3 mill/wk while honouring 2nd doses 12 wks after 1st.

After 6 weeks all adults offered 1 dose. At 4 mill/wk after, all 2nd doses by mid July. 4/6
I don't know what the vaccine procurement is looking like. I don't know what plan is. Moderna due to kick in Spring?

BUT *if* we could do this we could offer 2 doses of vax to all adults by mid July instead of early Sept under const 3 mill/week.

Is it worth it? 5/6
Two months may not seem that much - and offering to everyone by Sept would still be great - but doing it by July would make opening up *safer* AND make us less vulnerable to growing our own vaccine resistant strain of Covid. 6/6

(calc details follow)
Calcs 1/2
In calcs above, I've:
- assumed 53 million adults over 16 in UK
- assumed 2nd doses take priority over 1st doses if 12 week interval due
- Remaining capacity after satisfying 2nd dose demand is used for 1st doses

and
Calcs 2/2:
- Calc 2nd dose demand by num 1st vax given 12 weeks earlier minus num 2nd vax given 3 weeks later (for doses given to 7 Feb)
- after all 1st doses offered, use max capacity each week for 2nd doses (allow <12 week interval to second dose).

Back of envelope stuff!

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More from @chrischirp

12 Feb
1. THREAD on latest UK Covid Numbers:

A reasonably detailed dive into the latest numbers & (some) implications.

TLDR: things going in right direction but don't think unlocking will be easy.
2. Confirmed cases are still falling & we are back at levels last seen in early December. Positivity rates (accounting for changes in numbers of tests) are also falling in all 4 nations (and in all age groups).

ONS infection survey entirely consistent with this picture.
3. Cases and positivity rates also falling across all English regions & LAs. However, E. Mids, Yorks & Humber and N.East falling slowest.

Obviously falls are GOOD, BUT the green diamonds show where we were at the end of Aug last year.

There is a LONG way to go.
Read 20 tweets
9 Feb
MINI THREAD: One way in which the Kent (B117) variant might help us vs SA variant... Both are more transmissible that older variants & so quickly become dominant.

BUT SA not more transmissible than Kent (we think) - so Kent, already dominant in UK, should stay dominant. 1/2
This is good because all vaccines work well against Kent (B117) & it doesn't seem to be re-infecting people who've already had covid.

But SA can re-infect people & evade (somewhat) AZ vax. Unknown is how that might help SA over time as it has more people it can spread to. 2/2
Read 4 tweets
6 Feb
THREAD ON FLU:
Just an attempt to start a conversation about annual flu.

I'm not an expert on this at all and welcome people's thoughts and insights...

Basic question is: how many annual flu deaths are acceptable? 1/7
In a "normal" year there might be c. 10,000 deaths from flu in England & Wales, mostly in people over 65.(greenwichccg.nhs.uk/News-Publicati…),

Timing & number varies depending on flu strain, how good that year's vaccine is & vaccine uptake.

Flu is also LESS infectious than Covid. 2/7
And the measures that work against Covid, work against Flu -> so this year we've seen HARDLY ANY flu.

The chart below compares English hospital flu admissions - but same picture for GP swabs, 111 calls etc.

Same across Europe (flunewseurope.org) 3/7
Read 7 tweets
29 Jan
SHORT THREAD ON SCHOOLS:
When schools go back is a tricky issue. I'm not going to get into it here BUT wanted to highlight a couple of data points from PHE surveillance & ONS infection survey this week. 1/5
Firstly, since early Jan, there have been a number of outbreaks at nurseries (open) & special need schools (30% attendance) (and yes - Covid).

A few at primary schools (20% attendance) and v few at 2nd-ary schools (5% attendance). 2/5
Added to that among young school age kids, case rates going down for primary school ages but UP in pre-school and nursery age children.

Secondary school age going down (not shown). 3/5
Read 5 tweets
29 Jan
MINI THREAD ON HOSPITALISATIONS:

The number of people in hospital with Covid is either flat or coming down in all 4 nations - excellent and a sign that infections really are going down (at least in older groups).

BUT they are still higher than April peak everywhere 1/4
In England, hospital admissions are now coming steadily down from 12th Jan peak and are now below the April peak too... good! 2/4
This is true for all regions of England (good!). You can see that they started going down in previous tier 4 regions (London, SE, EoE) about 7-10 days earlier than other regions. 3/4
Read 4 tweets
26 Jan
Giving some examples on @BBCOne @BBCNews just now about why we we could have - and should have - avoided more than100,000 people dying from Covid.
Other missed opportunities: not making workplaces safer (e.g. DVLA, Sainsbury outbreak, high care worker deaths), not making schools safer, not anticipating uni surges in autumn, etc...
But I did say, and do believe, that the vaccination programme is going very well. So let's acknowledge that at least.
Read 4 tweets

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