The groove area or pancreaticoduodenal groove involves the space between the duodenum, the head of the pancreas and the common bile duct karger.com/Article/FullTe…
Groove pancreatitis is a segmental chronic pancreatitis that affects the groove area; it was described in 1973 by Becker link.springer.com/book/10.1007/9…
There are different names for this condition, some of them are specific conditions according to some authors: paraduodenal pancreatitis, cystic dystrophy of heterotopic pancreas, myoadenomatosis, periampullary duodenal wall cyst, and pancreatic hamartoma of the duodenum.
One special condition is cystic dystrophy of heterotopic pancreas: it involves duodenal wall inflammation and cysts due to inflammation of heterotopic exocrine pancreatic tissue of the duodenal wall.
The most frequent etiology for GP is alcohol and tobacco (both in the literature and in my personal experience). For this reason the usual patient with GP is a male patient in the 4th-5th decade
According to a systematic review the median age of 47 years (range, 34 to 64 y), with 90% male, 87% smokers, and 87% alcohol consumption journals.lww.com/jcge/Abstract/…
GP may be associated to abdominal pain, duodenal obstruction and jaundice. It is frequently associated to typical signs and symptoms of chronic pancreatitis (calcifications, dilated main pancreatic duct…), and most patients have pancreatitis-like symptoms
According to the systematic review, most patients presented with abdominal pain (91%) and/or weight loss (78%). Imaging frequently showed cystic lesions (91%) and duodenal stenosis (60%) journals.lww.com/jcge/Abstract/…
Treatment depends on symptom severity, response to conservative treatment and the development of complications. Endoscopy is an option in case of obstructive cysts, jaundice, but 1/3 patients initially treated by endoscopy are finally referred for surgery journals.lww.com/jcge/Abstract/…
Surgery is the most effective treatment with 80% complete symptom relief, but often conservative management and endoscopy are performed first journals.lww.com/jcge/Abstract/…
Thanks to @GVAsalualicante radiology and pathologic Departments for the images!
Now, what is your experience with groove pancreatitis?
Cross-sectional imaging often reveals unexpected pancreatic cystic lesions, it is a frequent clinical problem, Should we observe or remove it? What's the diagnosis? Is our patient in danger of malignancy?
Don’t miss this @aegastro@my_ueg#EducAEG#UEGambassador twitter thread
Importance of Pancreatic Cystic Neoplasms (PCN):
Most are asymptomatic at diagnosis, frequency increases with age
Symptoms: acute pancreatitis (Wirsung obstructed by the cyst or mucus), pain, obstructive chronic pancreatitis, jaundice
> symptoms, >malignancy risk!
Classification of PCN:
Mucinous: intraductal papillary mucinous neop. and mucinous cystic neop.
Nonmucinous: serous cystic neoplasm, solid pseudopapillary neoplasm and cystic neuroendocrine tumours
Endoderm- derived columnar epithelium is characteristic for mucinous lesions
👇
For ancient physicians the most important feature of diabetes was the increased urine output. Diabetes was a term for polyuria derived from the classical Greek word "diabainein" meaning to walk with the legs apart, later diabetes "a passer through" or a "siphon".
The Greek physician Arateus (credited for the term Diabetes) described it as "the melting down of flesh and limbs into urine"
Pancreatic juice is composed by
- Acinar secretion, rich in enzymes
- Ductal secretion: A) Water that will help to flush the acinar secretion B) Bicarbonate that will neutralize gastric acid in the duodenum; some enzymes like lipase do not work in an acid environment
The arrival of acid and protein products to the duodenum induce S-cells to produce secretin which stimulates ductal secretion. Fatty acids, amino-acids and vagus nerve induce I-cells to produce cholecystokinin (CCK) which stimulates acinar secretion