Thread by @Mangan150

Coffee induces autophagy, the self-cleansing process that rids cells of junk molecules, in vivo

Inhibits mTOR, which leads to longer life.

Both caf and decaf. Health benefits.

tandfonline.com/doi/abs/10.416…

In liver and muscle, but not heart, tissue, regular coffee induced autophagy more strongly than decaf, indicating a possible independent effect of caffeine.

"Coffee ingestion causes global deacetylation of proteins and hence mimics caloric restriction"

Indeed, "caffeine surprisingly is a potent stimulator of hepatic autophagic flux"

Caffeine reduces liver fat and stimulates β‐oxidation (fat burning) in hepatic cells and liver by an autophagy pathway

Which means it treats fatty liver

aasldpubs.onlinelibrary.wiley.com/doi/full/10.10…

How much coffee do you need to promote autophagy?

Equivalent human dose is about 2.5 mg/kg of body weight

For a 70 kg person that's 175 mg caffeine

well within the range of normal consumption: a 12-oz Starbuck's brewed coffee has 235 mg caffeine

caffeineinformer.com/the-complete-g…

Coffee drinking is associated with a 30% reduced risk of non-alcoholic fatty liver disease (NAFLD)

ingentaconnect.com/content/wk/ejg…

Coffee inhibits the mTOR pathway and has anti-aging effects

paperchase-aging.s3.amazonaws.com/pdf/xiMxhBgkCt…

In Japan, coffee drinking was associated with a lower risk of all-cause mortality, as well as lower risk of death from heart disease, stroke, and respiratory disease.

academic.oup.com/ajcn/article/1…

Conclusion: coffee in moderate amounts appears to be good for you.

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