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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
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1 Mar, 4 tweets, 1 min read
Linoleic acid, the main component of seed oils, increases endogenous cannabinoids and promotes weight gain

At 8% of dietary energy, which is around the level Americans consume.

aocs.onlinelibrary.wiley.com/doi/full/10.10…
New study: Fat tissue from obese people has higher levels of omega-6 (seed oils) and higher levels of endogenous cannabinoids.

Omega-3 (fish oil) can normalize cannabinoid levels.

portlandpress.com/clinsci/articl…
An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

Hyperactivity of the cannabinoid system may be one mechanism

mdpi.com/2072-6643/8/3/…
Abundant evidence says that seed oils are NOT "heart healthy", as the establishment wants you to believe.

Avoid them, and eat fish for better body composition.

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More from @Mangan150

P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
3 Mar
Hormesis is a fundamental concept in biology, and in health and disease.

Importantly, you can use hormesis deliberately to improve your own health and live longer.

What is hormesis?

Thread 👇
Hormesis is a process in which exposure to a low dose of a toxin or stressor that is damaging at higher doses induces an adaptive beneficial effect on the cell or organism.

Hormesis is ubiquitous in living things.
Hormesis is fundamental to living organisms' ability to survive and thrive against the assaults of the environment

Hugo Schulz discovered hormesis in 1884 when he noted that yeast cells grew better in the presence of low doses of chemical disinfectants. Image
Read 11 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
26 Feb
63.5% of U.S. Covid hospitalizations were due to obesity, diabetes, hypertension, and heart failure.

In other words, conditions almost entirely avoidable.

ahajournals.org/doi/full/10.11…
88% of Americans have at least one metabolic abnormality.

Prevalence of non-alcoholic fatty liver in a "healthy" population ages 28-70 was 46%.

NAFLD is closely linked to obesity and eating garbage food.

gastrojournal.org/article/S0016-…
Read 4 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
25 Feb
Coffee induces autophagy, the self-cleansing process that rids cells of junk molecules, in vivo

Inhibits mTOR, which leads to longer life.

Both caf and decaf. Health benefits.

tandfonline.com/doi/abs/10.416…
In liver and muscle, but not heart, tissue, regular coffee induced autophagy more strongly than decaf, indicating a possible independent effect of caffeine.

"Coffee ingestion causes global deacetylation of proteins and hence mimics caloric restriction"
Indeed, "caffeine surprisingly is a potent stimulator of hepatic autophagic flux"

Caffeine reduces liver fat and stimulates β‐oxidation (fat burning) in hepatic cells and liver by an autophagy pathway

Which means it treats fatty liver

aasldpubs.onlinelibrary.wiley.com/doi/full/10.10…
Read 9 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
25 Feb
Muscle has an underrated role in health and disease.

Targeting increased muscle mass and improved muscle metabolism is critical.

Resistance training and adequate high quality protein are essential.

The mainstream doesn't get this.

academic.oup.com/ajcn/article/8…
A single bout of exercise increases levels of the powerful longevity protein klotho.

The smaller increase in the elderly is likely due to lower muscle mass.

Get and keep muscle for long life.
frontiersin.org/articles/10.33…
Read 5 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
21 Feb
Resistance training has huge health benefits, including preventing disabilities, and decreasing risk of heart disease and cancer.

"virtually all the benefits of resistance training are likely to be obtained in two 15- to 20-min training sessions a week."

sciencedirect.com/science/articl…
Strength training: single vs multiple sets
If lifting to failure, a lower load resulted in similar muscular hypertrophy as a heavier one.

journals.physiology.org/doi/full/10.11…
Read 5 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
20 Feb
Insulin drops dramatically during the first 24 hours of fasting, which enables lipolysis, or the breakdown and exit of fat from fat cells.

Lower insulin may account for most of the benefits of intermittent fasting. Image
journals.physiology.org/doi/abs/10.115…
Obese women have less of a decline in insulin during fasting than lean women.

Might partly explain why they're obese in the first place: they can't properly access fat stores from fat cells, making them hungrier. Image
Read 6 tweets

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