@Daoyu15@franciscodeasis@spectropan@ResearchGate@TheSeeker268 Despite claims by Abouelkhair MA. (2020) in "Non-SARS-CoV-2 genome sequences identified in clinical samples from COVID-19 infected patients" that these viral sequence traces are "Evidence for co-infections" doi.org/10.7717/peerj.…
It is clear that this patient WAS NOT INFECTED...
@Daoyu15@franciscodeasis@spectropan@ResearchGate@TheSeeker268 WITH A mysterious Bulgarian Bat Virus "BM48-31/BGR/2008". Instead it is yet more evidence of cross-contamination of Illumina sequence machines used by WIV as they were as far as we know the only institution in Wuhan to have experimented with this virus.
Correct me if I am wrong?
Compilation Thread on ORF8 ORF8 or Fate? 1. ZLS (2018):
"Considering the variability of orf8 in bats, civets and humans, investigating the function of orf8 is a priority, particularly the contribution of these different variants to viral pathogenesis."
2. ORF8 or Fate?
"In addition to receptor binding, proteolytic cleavage of S & potentially other mutations that affect virion & trimer stability may be important for virus transmissibility in different hosts, & these factors need to be studied further." nature.com/articles/s4157…
3. ORF8 or Fate?
Overwhelmingly these viruses had mutations or
29 deletions in ORF8 - associated with reduced replicative fitness of the virus.. may be associated with host adaptation
via @CarltheChippy
382-nt deletion during early evolution of SARS-CoV biorxiv.org/content/10.110…
(A and B Sequence & structural properties of insert PRRA (D) Sequence similarity between close neighborhood of PRRA insert, neurotoxin motifs Y674QTQTNSPRRAR685, homologous to Ophiophagus (cobra) & Bungarus genera & 3 RABV strains & HIV-1 gp120 superantigenic motif in last row
Study on Ribonuclease From Snake Venom of Zhejiang Cobra (Naja naja atra)
ZHANG Gon-jin
Wuhan Institute of Virology,Academia Sinica zoores.ac.cn/article/id/1281
2. Common Contaminants in NGS
Until an effective strategy is found to eliminate contaminants from sequencing runs, novel sequences detected in such runs should be scrutinized by qPCR analysis to ensure they originate from specimens rather than the lab journals.plos.org/plosone/articl…
AN ASSESSMENT OF CHINA’S BIOLOGICAL WARFARE CAPABILITIES AND NEED FOR GLOBAL APPROACH TO BIO-SECURITY Part 1 (Indian Analysis, May 2020) researchgate.net/publication/34…
Same covid-19 mutations are appearing in different places, which may or may not be strange....
41,000 mutations documented in 880 lineages.
Most in spike protein
What explains it?