As far as thiamine (vitamin B1) supplements go, there are only a few primary forms to be aware of:
Thiamine hydrochloride, the basic salt form, very common in supplements, not the most potent, but less likely to cause side effects as it doesn't need other nutrients to activate
Thiamine hydrochloride, the basic salt form, very common in supplements, not the most potent, but less likely to cause side effects as it doesn't need other nutrients to activate
Benfotiamine, less common, but one of the more potent forms, generally reported to be more stimulating than other forms so it's best taken in the morning, it's structure contains sulfur which may rarely cause reactions in individuals with certain sulfur metabolism issues
Allithiamine (TTFD), the most potent form, bypasses all transporters entering cells directly, should be dosed much lower than other forms, and more likely to cause side effects as its activation requires B12 and glutathione, may also react negatively with heavy metal toxicity
Thiamine mononitrate, the cheapest form to produce, but also the most poorly absorbed form, this is the form usually found in fortified wheat products, no reason to use it, as thiamine hydrochloride is a similar price with better potency
Sulbutiamine, another sulfur-based form with a similar potency to benfotiamine, this form is actually pharmacologically active on the acerylcholine system and may upregulate D2 dopamine receptors, used as a nootropic by many biohackers, but also has some odd side effect reports
Overall if you want to try megadosing thiamine as I've covered in the past, I'd taper up to 1-2g of thiamine hydrochloride to establish a baseline, then adding an additional form like benfotiamine or TFFD if desired, I generally cycle off the megadose after a few weeks
Personally I wouldn't bother with thiamine mononitrate at all, I haven't had the chance to experiment with sulbutiamine but if I do I'll write more on that later
Thiamine side effects typicallu stem from deficiency in key cofactors, sulfur metabolism issues, or mercury toxicity
Thiamine side effects typicallu stem from deficiency in key cofactors, sulfur metabolism issues, or mercury toxicity
By far the biggest cofactor in thiamine metabolism is magnesium, so I always pair the two together
If you're deficient in other key B-vitamins like B12, folate, or B6, this may also cause symptoms, in some cases side effects can be resolved with a B-complex added every few days
If you're deficient in other key B-vitamins like B12, folate, or B6, this may also cause symptoms, in some cases side effects can be resolved with a B-complex added every few days
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