This is a collection of research studies on the effects of grounding, a rapidly growing health practice in which someone touches their bare skin to the earth's surface for some time
Grounding may work by feeding free electrons into the water-protein semi-conduction network throughout the body
Grounding has also been proposed to work through activation of the ventral vagus nerve, and provide benefits similar to other forms of vagus nerve stimulation
The most common results found in these studies seem to be reduction in inflammation and oxidative stress, reduced blood pressure and viscosity, reduced cortisol, improved mood, better sleep, normalized circadian rhythm, and reduced pain and fatigue
Integrative and lifestyle medicine strategies should include Earthing (grounding): Review of research evidence and clinical observations pubmed.ncbi.nlm.nih.gov/31831261/
The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases pubmed.ncbi.nlm.nih.gov/25848315/
The Effects of Grounding (Earthing) on Bodyworkers' Pain and Overall Quality of Life: A Randomized Controlled Trial pubmed.ncbi.nlm.nih.gov/30448083/
The biologic effects of grounding the human body during sleep as measured by cortisol levels and subjective reporting of sleep, pain, and stress pubmed.ncbi.nlm.nih.gov/15650465/
Earthing (grounding) the human body reduces blood viscosity-a major factor in cardiovascular disease pubmed.ncbi.nlm.nih.gov/22757749/
Changes in pulse rate, respiratory rate, blood oxygenation, perfusion index, skin conductance, and their variability induced during and after grounding human subjects for 40 minutes pubmed.ncbi.nlm.nih.gov/20064020/
• • •
Missing some Tweet in this thread? You can try to
force a refresh
Melatonin is my favorite molecule in the body, it regulates circadian rhythm, the immune system, and gene expression, and acts as a antioxidant within both cells and mitochondria
This is a collection of a few of my favorite studies on melatonin, specifically focused on endogenous function and production
As far as thiamine (vitamin B1) supplements go, there are only a few primary forms to be aware of:
Thiamine hydrochloride, the basic salt form, very common in supplements, not the most potent, but less likely to cause side effects as it doesn't need other nutrients to activate
Benfotiamine, less common, but one of the more potent forms, generally reported to be more stimulating than other forms so it's best taken in the morning, it's structure contains sulfur which may rarely cause reactions in individuals with certain sulfur metabolism issues
Allithiamine (TTFD), the most potent form, bypasses all transporters entering cells directly, should be dosed much lower than other forms, and more likely to cause side effects as its activation requires B12 and glutathione, may also react negatively with heavy metal toxicity
In the eyes DHA serves the integral function of capturing light that's been lifted to the UV spectrum and released by oxidized vitamin A bound to light receptor proteins
DHA's dense electron clouds capture the energy of the re-released light and transfer it into a neural impulse
To put it more simply, light hits a light receptor protein which uses vitamin A as a cofactor
The light is captured by the protein and excites vitamin A, raising its energy state
When its energy state drops down the difference between the two states is added to the light energy
As a result, the light is re-released within the UV spectrum through fluorescence
The membranes around the light receptors are filled with DHA, which absorbs light within the UV spectrum
The light interacting with the DHA excites it's electrons, creating a current
I think everyone is familiar with the psychological symptoms of dehydration, but few are aware of the symptoms of water intoxication, which although unhealthy and difficult to achieve, are reported to resemble a drunken state, and in extreme cases cause confusion and seizures
Oddly I can find no concrete mechanism to explain the mental states associated with water intoxication
My personal theory is that this works either through dilution of ions used in neuron signaling like Na+, or through downregulation of aquaporin water channels used in neurons
Ecdysteroids are an interesting class of compounds I've been experimenting with recently, they're steroid compounds that function as androgens in insects, but are also produced by a few different plant species
(thread)
Interestingly, they seem to provide some anabolic effects in mammals as well, but are not androgenic, and don't increase testosterone
Interestingly, this effect is thought to work primarily through the binding of the ecdysteroids to the estrogen receptor beta subset, which is implicated more in bone/muscle growth, with lower activation at the alpha-ER which is more "feminizing"