1/
What is vaccine effectiveness in the most vulnerable population? Is it indeed >90%?
What is happening shortly after dose 1 of the vaccine?
A large cohort study (Denmark) of nursing home residents (and health care workers) provide interesting answers
medrxiv.org/content/10.110…
What is vaccine effectiveness in the most vulnerable population? Is it indeed >90%?
What is happening shortly after dose 1 of the vaccine?
A large cohort study (Denmark) of nursing home residents (and health care workers) provide interesting answers
medrxiv.org/content/10.110…
2/
Retrospective cohort during vaccination campaign, which coincided with winter wave
Key points:
Wave trajectory (date) was a major confounder.
Estimated effectiveness of full vaccination much lower in nursing home residents (64%) than health care workers (90%)
Retrospective cohort during vaccination campaign, which coincided with winter wave
Key points:
Wave trajectory (date) was a major confounder.
Estimated effectiveness of full vaccination much lower in nursing home residents (64%) than health care workers (90%)
3/
Not surprising. The claim that effectiveness is just as high in the elderly does not fit knowledge of immune response with aging.
See here, for example.
Not surprising. The claim that effectiveness is just as high in the elderly does not fit knowledge of immune response with aging.
See here, for example.
https://twitter.com/prof_shahar/status/1369178246831431684
4/
Important:
1st dose vaccination INCREASED the risk of infection in the following 2 weeks (vs. unvaccinated), in both nursing home residents and health care workers.
Graph created from data in Table 2.
Important:
1st dose vaccination INCREASED the risk of infection in the following 2 weeks (vs. unvaccinated), in both nursing home residents and health care workers.
Graph created from data in Table 2.
5/
Other analyses point to suspicious events shortly after dose 1.
Infection at vaccination site?
Vulnerable period (coinciding infection & 1st dose vaccination)?
Both?
Other analyses point to suspicious events shortly after dose 1.
Infection at vaccination site?
Vulnerable period (coinciding infection & 1st dose vaccination)?
Both?
https://twitter.com/prof_shahar/status/1369287124541870082
6/
Here is another intriguing observation on 1st dose vaccination (data from Israel).
Here is another intriguing observation on 1st dose vaccination (data from Israel).
https://twitter.com/prof_shahar/status/1368222341352673280
7/
Death recorded in the Danish study, but not analyzed as endpoint.
Why?
They were not curious to see the results for the most important endpoint?
Reserved for another paper?
About 40% of COVID death are nursing home residents.
ltccovid.org/2020/04/12/mor…
Death recorded in the Danish study, but not analyzed as endpoint.
Why?
They were not curious to see the results for the most important endpoint?
Reserved for another paper?
About 40% of COVID death are nursing home residents.
ltccovid.org/2020/04/12/mor…
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