I've been working on ways to actively limit the effects on xenoestrogens beyond just limiting exposure
So far, the most promising compound I've found for this purpose is diindolylmethane, also known as DIM
Let me expand on this:
First, let's look at the primary mechanisms by which xenoestrogens cause endocrine disruption
They are thought to act primarily by binding to the aryl hydrocarbon (Ah) receptors, altering gene expression of hormone metabolism enzymes, and by binding to estrogen receptors
Activating of the Ah receptors is primarily what skew hormone balance by increase the conversion of testosterone into estrogen by aromatase
DIM is a weak but competitive ligand at both the Ah receptors and estrogens receptors, as well as a mild aromatase inhibitor
This means that DIM actually takes up space on these receptors, competing with xenoestrogens
This may offer some protection against their effects by reducing their ability to bind to these receptors without increasing the activation of the receptors themselves
DIM also has the ability to reduce toxic estrogen metabolites, as some estrogen is kicked off its receptors and broken down
It does this by shifting enzyme activation away from the pathway that creates 4-hydroxy-E1 and 16-hydroxy-E1 (carcinogenic), and towards 2-hydroxy-E1
Xenoestrogens have the opposite effect, actually increasing production of carinogenic estrogen waste pathways
The effects of DIM are potent enough that it's being researched for its anticancer potential, specifically in hopes of reducing breast cancer rates
DIM is a metabolite of indole-3-carbinol, a compound naturally occurring in cruciferous vegetables including my personal favorite, broccoli sprouts
DIM can be supplemented on its own, or physiologically active doses can be obtained from food sources
The optimal dose range for DIM is reported to be between 100-200mg, as it's speculated that at higher doses it begins to promote aromatase activity rather than suppress it
I use it as a supplement paired with broccoli sprouts for the added benefits of sulfurophane on liver detox
Other candidates for compounds to reduce aromatase and estrogen receptor activation from xenoestrogens include lignans in flaxseed and apigenin in chamomile
I'm still looking for other compounds that reduce Ah receptor activation, I'll post an update if I find more
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Calpains are calcium-dependent regulators of the entire body
Specifically they model glutamate/GABA in the central nervous system, excess calcium activation overrides normal calpain function and causes their overexpression
Calpain overexpression breaks down gephyrin, GABA receptors, and chloride clearance channels which = excitotoxicity and in extreme cases disease like epilepsy
This is how epileptic states are kindled by substances that drive up calcium channel activation, like alcohol
Calpains seem to play a role in other calcium-related aspects of health like bone metabolism and heart disease as well
Alkaline phosphatase enzymes counteract their activity, these enzymes are magnesium dependent and I believe they may be upregulated with megadose magnesium
I think a lot of people assume that because I talk about a lot of different supplements I must take dozens of them each day
The truth is that honestly at this point I often go a week or two at a time without taking any pills whatsoever
My goal has always been to use as few substances as possible
When I was focusing on neurogenesis originally, it required a lot more maintenance, but the last few months I've been able to minimize significantly
At this point I use almost solely herbs, either in tea, or occasionally as formulations I've put together like adaptogen coffee
I've been using ULDN, ku shen, and maral daily, adaptogen coffee and vitality tonic every few days, and magnesium topically/orally as needed, that's it
Just because I've created a patreon does not mean I'm going to stop sharing the same quality and depth of information on twitter
It's simply a way for those of you who prefer longform writing and would like to ask me questions directly to support my work if you choose to
Creating in articles and lectures like this takes hours, if not days in some cases, this will allow me to provide content on the level normally reserved for those I consult with for much cheaper
If you don't want to pay anything, that's okay, my presence here will stay the same
The only thing I can't post here is phrasing that implies medical "treatments" or "cures" for different conditions, I wiped past tweets to give me the chance to rewrite anything I may have worded poorly in the past, and expand on it with my more recent research
Melatonin is my favorite molecule in the body, it regulates circadian rhythm, the immune system, and gene expression, and acts as a antioxidant within both cells and mitochondria
This is a collection of a few of my favorite studies on melatonin, specifically focused on endogenous function and production
This is a collection of research studies on the effects of grounding, a rapidly growing health practice in which someone touches their bare skin to the earth's surface for some time
Grounding may work by feeding free electrons into the water-protein semi-conduction network throughout the body
Grounding has also been proposed to work through activation of the ventral vagus nerve, and provide benefits similar to other forms of vagus nerve stimulation
The most common results found in these studies seem to be reduction in inflammation and oxidative stress, reduced blood pressure and viscosity, reduced cortisol, improved mood, better sleep, normalized circadian rhythm, and reduced pain and fatigue
As far as thiamine (vitamin B1) supplements go, there are only a few primary forms to be aware of:
Thiamine hydrochloride, the basic salt form, very common in supplements, not the most potent, but less likely to cause side effects as it doesn't need other nutrients to activate
Benfotiamine, less common, but one of the more potent forms, generally reported to be more stimulating than other forms so it's best taken in the morning, it's structure contains sulfur which may rarely cause reactions in individuals with certain sulfur metabolism issues
Allithiamine (TTFD), the most potent form, bypasses all transporters entering cells directly, should be dosed much lower than other forms, and more likely to cause side effects as its activation requires B12 and glutathione, may also react negatively with heavy metal toxicity