#KetoMedStudy
Week #5
1/5

For past 4 wks, we've been sharing study design details of forthcoming Keto vs Mediterranean Study

This week, we want to share the 36-wk time point & get your thoughts.

Poll on next post in thread - vote on time point you think is most interesting 🤔
2/5
Which is most interesting?

Adherence best at Wk #4 of each phase (food delivered)
⬆️rigor (efficacy)

Wk #12 of each phase
⬆️generalizabilty

36 wk - reality check (effectiveness)
Who is following what?
3/5

Caveat

Primary outcome=HbA1c (ct.gov)
12wk Keto vs 12wk Med, relative to baseline

HbA1c not appropriate for assessing 4 wk change

We have Hba1c @ wks 0, 12, 24 & 36
We have CGM glucose @ wks 0, 4, 12, 16, 24

(Not enuf $$ to get CGM @ wk 36) 🙁
4/5

Participants tried both diets for 12 wks each.
Mastered them with support of @Dalita (diet whisperer, MS, RD, CDE)

Watched their glucose results on CGM (Dexcom) on both diets

Then 12 wks with no staff support or contact!

Doncha wanna know what they're eating?
Week #36 😱
5/5

See ya next week, when we share our definitions of "adherence" to WFKD, and Med-Plus

@TheGuyititian
@LuciaAronica
@Dalita
@SunKimMD
@BladierClaire
@GardnerPhD

(Teaser - Design & Adherence paper accepted today!
🍾🥂 Will share when published. Still working on main paper)

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Christopher Gardner

Christopher Gardner Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @GardnerPhD

13 Feb
1/9
Just completed trial
Keto vs Mediterranean

Just submitted Design & Adherence paper PRIOR to main results paper

While waiting for reviews & decision…
 ~10 weekly mini-threads - #KetoMedStudy

⬆️design understanding &
⬆️twitter civility?🙏
 
Week #1
Main study question Image
2/9
US calories: 1999-2016
pubmed.ncbi.nlm.nih.gov/31550032/

Low quality carbs
Added sugars, refined grains: ~40%

High quality carbs (whole grains, legumes, fruits): ~10%

3 types fat: ~10% each

Protein: Animal ~10%; plant ~5%

***Biggest impact potential - ⬇️ low quality carbs Image
3/9
Most/all healthy diet patterns recommend avoiding/minimizing added sugars & refined grains, while including non-starchy vegetables

Is there additional overall health benefit to also eliminating:
*Legumes/beans
*Whole intact grains
*Fruits

Poll next tweet Image
Read 9 tweets
30 Sep 19
Series of 6 papers published today in Ann Int Med from “NutriRECS” group.

They recommend people continue to consume unprocessed & processed red meat at current rates

I disagree, in USA

My perspective - in 17 tweets
#ReduceRedMeat in USA

n.pr/2mkxWN7
2 of 17

I seek to dispute it
As does @TrueHealthINIT & @HSPHnutrition

It isn’t hard
3 of 17

The recommendations are stated to be “weak, with low-certainty evidence”.
I agree.

Beyond weak, they are reckless.
They will confuse the public & undermine scientific credibility.
Potential to harm public health & environment.
Read 17 tweets
6 Jun 19
Apologies for not responding sooner with specifics to @bigfatsurprise @ProfTimNoakes with specifics.
Here are some......
Fundamental flaw
Yes, RCT’s are design w/ highest causal inference
But many topics can’t be studied w/ RCT
Can’t randomly assign & follow until morbidity/mortality:
*Cigarettes & lung cancer
*Parachutes when sky diving
*Vegan/Vegetarian
Lack of RCT does not = lack of evidence
Claim about review of nutritional epi findings-“0% [to 20%] confirmed in clinical trials”
Refuted?
Or not conducted?
There are very few RCT nutrition trials w/ hard outcomes
Most are done with supplements, not foods
Not surprising that few are “confirmed” if few are “conducted”
Read 12 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!