Thread by @GardnerPhD

#KetoMedStudy
Week #5
1/5

For past 4 wks, we've been sharing study design details of forthcoming Keto vs Mediterranean Study

This week, we want to share the 36-wk time point & get your thoughts.

Poll on next post in thread - vote on time point you think is most interesting 🤔

2/5
Which is most interesting?

Adherence best at Wk #4 of each phase (food delivered)
⬆️rigor (efficacy)

Wk #12 of each phase
⬆️generalizabilty

36 wk - reality check (effectiveness)
Who is following what?

3/5

Caveat

Primary outcome=HbA1c (ct.gov)
12wk Keto vs 12wk Med, relative to baseline

HbA1c not appropriate for assessing 4 wk change

We have Hba1c @ wks 0, 12, 24 & 36
We have CGM glucose @ wks 0, 4, 12, 16, 24

(Not enuf $$ to get CGM @ wk 36) 🙁

4/5

Participants tried both diets for 12 wks each.
Mastered them with support of @Dalita (diet whisperer, MS, RD, CDE)

Watched their glucose results on CGM (Dexcom) on both diets

Then 12 wks with no staff support or contact!

Doncha wanna know what they're eating?
Week #36 😱

5/5

See ya next week, when we share our definitions of "adherence" to WFKD, and Med-Plus

@TheGuyititian
@LuciaAronica
@Dalita
@SunKimMD
@BladierClaire
@GardnerPhD

(Teaser - Design & Adherence paper accepted today!
🍾🥂 Will share when published. Still working on main paper)