Hospitalizations for #COVID19 down -10.4% in past 7 days (covid.cdc.gov/covid-data-tra…) in US and record-low in UK today (coronavirus.data.gov.uk/details/health…). For 2nd week in row, US COVID19 hospitalizations lower than 2018, 2019 influenza hospitalizations. Keep eye on prize. ImageImage
Pfizer analysis had shown that unvaccinated individuals were 44 times more likely to develop symptomatic COVID-19 and 29 times more likely to die from COVID-19. Is there study if the remaining people being hospitalized for #covid19 in UK are unvaccinated?
pfizer.com/news/press-rel…
On 2021 COVID-NET MMWR Wk 9 (From the CDC): 3.8 per 100k for COVID Hospitalizations.
On 2021 COVID-NET MMWR Wk 8: 4.3 per 100k for COVID Hospitalizations.
From 2019/2020 MMWR Wk 9: 4.4 per 100k for Influenza Hospitalizations.
From 2019/2020 MMWR Wk 8: 5.0 per 100k for
Influenza Hospitalizations.
From 2018/2019 MMWR Wk 9: 4.6 per 100k for Influenza Hospitalizations.
From 2018/2019 MMWR Wk 8: 4.6 per 100k for Influenza Hospitalizations.
From 2017/2018 FluView MMWR Wk 9: 3.6 per 100k flu
From 2017/2018 FluView MMWR Wk 8: 5.2 per 100K flu
Very heartened to see these decreasing hospitalizations for #COVID19 (most prominent in UK- astounding) which seems to be result of defanging virus by vaccination. Let's keep on vaccinating; okay to worry of course, but try to feel heartened today!
Here are data sources to look for yourself! COVID-19 hospitalizations: gis.cdc.gov/grasp/COVIDNet…
Laboratory confirmed influenza hospitalizations: gis.cdc.gov/GRASP/Fluview/…
Also, look at ER visits: covid.cdc.gov/covid-data-tra…. COVID now only 2.2% of all ER Visits. Vaccines working!

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More from @MonicaGandhi9

19 Mar
T cell thread: Wanted to address T cells a bit more and why I think the AZ vaccine actually would work to prevent severe disease against the B.1.351 variant (although the S. Africa trial was not allowed to continue to show this outcome). So, remember that immunity comprises two
arms - antibody responses and T cells. T cells are the major immune defense against viruses. For instance, since the HIV virus infects CD4 cells, those with advanced HIV are susceptible to severe viral (and parasitic) infections. So, HIV doctors think about "T cells" a lot! Ok, Image
as discussed before, T cell responses to natural infection or vaccines help protect you against severe disease with SARS-CoV-2. Some papers below on this: a functional T cell response will modulate the severity of disease if you get infected or after vaccination. Image
Read 16 tweets
18 Mar
Well, the court date is March 22 as our city is suing SFUSD to open schools stating "SFUSD's failure to reopen schools when it is safe to do so violates children's state constitutional rights"; the horrific impact on mental health for children highlighted.
sfcityattorney.org/2021/02/11/her…
In the meantime, despite all of the scientific data showing 3 feet is fine for distancing and the fact that many teachers are vaccinated now, the American Federation of Teachers is opposing the CDC changing their guidance form 6 to 3 feet
nytimes.com/2021/03/17/us/…
Vaccination changes everything for teachers; distancing is immaterial with the safety of vaccines (remember CDC guidance unmasked/undistanced) so there is something else going on that is not clear
theatlantic.com/ideas/archive/…
Read 5 tweets
17 Mar
Good news! Hospitalizations continue to drop in US, greater drops in older ages, showing vaccine effect. Drop of 13.4k in last 7 day hospitalizations, from February 24th - March 15th. 50+ yielded 81% of the drop in last 7 day hospitalizations. Half of the
beta.healthdata.gov/Health/COVID-1…
total drop came from 70+ (drop of 6.7k in last 7 day hospitalizations). COVID last 7 day hospitalizations drop most marked in older, what else could that be but vax?
-39.1% (Feb 24th/March 15th)
-21.2% (Feb 24th/March 7th)
-14.4% (Feb 24th/March 4th)
-12.1% (Feb 24th/March 1st)
70+ -- 10,355 vs. 12,399 vs. 13,814 vs. 14,616 vs. 17,019
-39.2% (March 15th)
-27.1% (March 7th)
-18.8% (March 4th)
-14.0% (March 1st) ......
60-69 -- 6,505 vs. 7,244 vs. 7,820 vs. 8,096 vs. 9,310
-30.1% (March 15th)
-22.2% (March 7th)
-16.0% (March 4th)
-13.0% (March 1st)
Read 4 tweets
14 Mar
I see there is a circulating concern here that SARS-CoV-2 will mutate into a more virulent virus from vaccines. That is not what usually happens. The reason that #HIV researchers/physicians think about mutations/variants a lot is that HIV's polymerase
journals.plos.org/plosbiology/ar…
has a very high mutation rate. SARS-CoV-2 and other coronaviruses on the other hand don't actually mutate that fast; their polymerase has a high fidelity to "proofreading" when they mutate. You just have been hearing about mutations lately in news.
pubmed.ncbi.nlm.nih.gov/21593585/
HIV doctors think about mutations a lot because HIV mutates readily to evade medications we use commonly so we have to always think about how to combine medications for HIV to avoid or overcome those mutations. But mutations come with a cost to virus
jvi.asm.org/content/81/6/3…
Read 4 tweets
13 Mar
This is my last tweet on SF school openings since Pediatrics ID Division at UCSF is taking on science-based approach to this. I know parents trust pediatricians to do what is best for children. Clearly, pediatricians want children/staff to stay healthy
sfchronicle.com/education/arti…
But poignant article from teen about how hybrid school can feel like compared to full in-person learning which can be informed by safety measures (3 feet distance - see academic.oup.com/cid/advance-ar…, masks, opening windows as we get into spring).
washingtonpost.com/opinions/if-th…
But I will give you an example from a clinic where I serve as medical director in SF. We were instructed by city to shut down for non-essential in-person visits on March 17 and soon found our vulnerable patients, SFGH with digital divide issues, marginal
journals.lww.com/aidsonline/Ful…
Read 7 tweets
13 Mar
Thread on transmission after vaccination without references since put in my previous thread- we may be determining our ideas on transmission after vax from rotavirus & other viruses without looking at unique features of SARS-CoV-2 & all the real world data we have:
While the clinical trials for the vaccines were not designed to assess whether vaccines reduced asymptomatic infection (and, thereby, transmission), there is biological plausibility that the antibodies and T-cell responses blocking symptomatic disease will also block asymptomatic
infection in the nasal passages. IgG immunoglobulins (generated and measured by the vaccine trials) enter the nasal mucosa. Moreover, SARS-CoV-2 vaccines also generate IgA (immunoglobulins at mucosa surface) which protect nasal passages from infection
researchsquare.com/article/rs-310…
Read 10 tweets

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