THREAD on SCHOOLS:

It's now 4 weeks since Scotland & Wales started a phased return to primary schools (secondary schools went back last week) & 2 weeks since all schools in England went back.

What is happening? 1/15
First let's look at Wales. They started sending young kids back to nursery and primary schools 22nd Feb. Older primary school kids & secondary school went back last week.

Wales publish new Covid incidents in schools - and (unsurprisingly) incidents are increasing. 2/15
Secondly, Scotland. There we have case data by age.

Primary school kids only get a test if they get symptoms. School staff can get tested without symptoms if they want. All positive cases from lateral flow device tests (LFDs) are PCR confirmed.

Testing has stayed flat. 3/15
So changes in case numbers by age are unlikely to be due to more tests being taken.

What do we see? Cases in kids under 14 definitely going up. Cases in older kids & adults have stopped falling - and *maybe* - have started creeping up.

Most under 64 unvaccinated. 4/15
Absolute numbers are low still but also many kids under 14 who get Covid will not get symptoms (and so won't get tested).

It's *possible* (but uncertain) that flattening & recent increase in other age groups are cases spreading to older school ages (household tranmission). 5/15
Certainly in week to 13th March, ONS infection survey saw signs of overall increase in cases in Scotland. 6/15
Finally, England where we have much less data so far. Massive increase in LFD tests since schools went back, but about same number of tests early this week compared to week 8th March. 7/15
The *first* 3 tests by pupils were done in school and positive cases did NOT get confirmatory PCR tests.

But this *does* mean that case numbers are quite up to date since LFD results come through within an hour.

LFD cases have gone *up* this week compared to last week. 8/15
These positives are unconfirmed by PCR, but given roughly same number of LFD tests week on week, unlikely to be a false positive effect, but probably is more transmission - again not really surprising given that loads more kids mixing and not really any more mitigations! 9/15
Overall, numbers of LFD positives are low compared to number of tests though.

But hard to interpret positivity rates. Given that LFD tests are hard to do and given that we know they are not that sensitive, we are likely missing cases too. 10/15
From end of this week onwards, LFD testing for students and staff shifts to *home* and is entirely voluntary. We are likely to see fewer tests done *and* they will likely be done less well -> fewer cases detected (bad). 11/15
But home tests *do* get confirmatory PCR (good) leading to fewer false positives (good). So we expect to see a natural reduction in *reported* cases as testing shifts to home. So even if *actual* cases increase over next few weeks might be hard to spot in the data. 12/15
By the time you might see spread into symptomatic cases in older ages we'll be in the school Easter holidays where you expect cases in children to drop quite a bit as we saw in Oct half term and Dec holiday. So interpretating data over next month in England will be hard! 13/15
But overall, clear signs from Scotland & Wales that opening schools does come with increased cases in children. This is not surprising. But if they spread to older age groups (as might be happening in Scotland), then that can push R>1 - not good. 14/15
Slowdown in rolling out vax to <50s, to honour 2nd doses (important to do!), means it will be a few months before many school staff & parents will be protected.

Will this slow the roadmap? Depends very much on what happens next few weeks and how govt reacts to the data. 15/15
PS for avoidance of doubt, I think we should try to avoid cases in kids too! I don't want people to think that I think it's fine for lots of kids to get Covid.
PPS I'm told that there *is* more testing in school kids happening in Scotland that might explain some or all of increases in ages 0-14 but I can't find the data on it (might not be public). Also more people out & about in recent weeks.

Interpretation is tricky, not definitive.
PPPS Note that however cautious you are about interpreting Scottish or Welsh data, it's not great news for England where we opened schools all at once and with far fewer mitigations in place.

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More from @chrischirp

20 Mar
THREAD on EUROPE:
Many headlines today about Europe's third wave, what it means for us and, in particular, international travel.

thetimes.co.uk/article/surge-…

Some thoughts about what it means... 1/11
Firstly, the current increases in Europe are because B117 (the Kent strain) has become dominant there - move than 70% in Denmark, NL, 50-70% in France, Belgium, Itlay, Germany & Austria. 2/11
As with us in Dec, they didn't act decisively to stop its spread - instead they've been in semi-restrictions (similar to our tier 3) - enough to bring *down* cases of old variant but not enough to stop B117.

B117 was only 5-10% in EU early Feb 3/11
Read 12 tweets
20 Mar
THREAD on vaccine effectiveness:

Public Health England released its updated report on real world effectiveness of Pfizer & AZ in England this week.
assets.publishing.service.gov.uk/government/upl…

I thought would be helpful to explain what they found...

TLDR: pretty good! 1/9
Firstly, both vaccines work almost equally well, so going to treat them as one in below.

Secondly, will focus on effect of ONE dose in OVER 80 year olds (most data!).

Effectiveness is higher in younger people and after second dose. 2/9
Right, so let's consider two lots of over 80s - 100,000 people in each group.

One group is unvaccinated and the other is more than two weeks out from their first dose.

(There seems very little real world protection for first two weeks after vaccination!!) 3/9
Read 10 tweets
17 Mar
THREAD on vaccination slowdown story:

TLDR: Don't panic!

Tonight a reduction is vaccine supply is being widely reported leading to a pause in rolling out vaccination to the under 50's... bbc.co.uk/news/uk-politi… 1/5
Basically, we gave about 11 million people their first dose mid Jan - mid Feb. They need their 2nd dose by end April.

We've been vaxxing about 2.5m/wk last few weeks, but let's say vax supply drops to about 2m/wk for April. Then we need ALL those doses to honour 2nd doses. 2/5
Once most of those are done, we can start rolling out vaccination to new people again (adults under 50) in May.

Assuming we can ramp up to 3.5m/wk from May, we can still offer everyone a 1st dose by mid July. 3/5
Read 6 tweets
17 Mar
THREAD on schools in England so far & what next:

Context:
A few million people already do Lateral Flow Device tests (LFDs) for work each week.

On 8th March schools reopened and secondary school students were asked to 3 LFDs at school - 2 last week and 1 early this week.
People with symptoms of Covid continue to get a single PCR tests.

People who test positive after taking LFDs at *home* or for health & care work can also get a PCR test to confirm the result.

People taking LFDs at work, at school or in a test centre do NOT get confirmatory PCR
IMPORTANT: PCR test results take a while to come through, so we can only ever use positive results from 4 or more days ago.

LFD test results report immediately, and so, where there is no confirmatory PCR, we can use test results up to yesterday.
Read 12 tweets
13 Mar
THREAD on Lateral Flow Device tests (LFDs):

They are being used more and more in England.

Thread about how they're used, why you NEED confirmatory PCR testing, how it will make interpretating case figures difficult as we open up.

#NerdyThread 1/19
LFDs are used to test people who don't have Covid symptoms - they give results in about 30 minutes.

The govt reckons about 30% of people with Covid don't have symptoms & this article suggested that asymptomic spread might account for 50% of cases.
jamanetwork.com/journals/jaman… 2/19
So the point is to find people who have Covid but don't know they have Covid & stop them mixing with, and potentially infecting, other people. 3/19
Read 23 tweets
12 Mar
THREAD on VACCINATIONS: how are we doing in England?

Although this week has seen fewer jabs, we've still given a dose to 2.5 million people over last 7 days.

It's also good to see 2nd doses starting to take off & 42% of people over 16 have had a dose.🍾

BUT some concerns 1/6
There are differences in coverage by deprivation. For over 70s, the differences are definitely there but high coverage in all groups.

The differences are starker by ethnicity, with black populations having the lowest coverage. 2/6
As ages get younger, the disparities by deprivation & ethnicity get more pronounced. Although coverage is still increasing for 65-69 year olds, it seems likely that coverage in most deprived populations will stay much below that of the least deprived & lower than 70+s. 3/6
Read 6 tweets

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