Good: AstraZeneca vaccine has 79% efficacy in new trial in US, Peru, and Chile. 100% efficacy for severe #COVID19. Good safety profile.
WHAT WOULD HAVE BEEN BETTER: if US approved the vaccine back in Dec 2020, like UK 🇬🇧. Could have saved more lives. nytimes.com/2021/03/22/bus…
2) Dr @VincentRK is right again, we should not have waited for an “American trial” before approving something if clinical trial evidence already showed it was 60-90% efficacious back in December.
Lives have been lost by this “American trial first” approach.
3) AstraZeneca is now FINALLY filing for EUA with the FDA.
It hadn’t done so for all these months yet in the Us!!!
4) Why did AstraZeneca not seek EUA from the FDA back in December? Because they screwed up relationships with the Trump FDA. It was quite a mess—but the science was still sound. But they didn’t get the tacit go ahead to submit for approval. And lives lost. nytimes.com/2020/12/08/bus…
WOW—25 new cases of #P1 variant suddenly appeared in British Columbia Canada 🇨🇦!! This is the variant from Brazil 🇧🇷 that is utterly decimating the country right now—and had ransacked Manaus 🇧🇷 despite high antibodies levels previously before it hit.
Loud protests erupted across Brazil as COVID-sceptic President Bolsonaro claimed citizens would soon be able to resume “normal lives” despite soaring death toll of 3200+ today.
~1/3 of all #COVID19 deaths worldwide today were in 🇧🇷. 🧵
2) “Bolsonaro, whose anti-science response to coronavirus has drawn international condemnation, made a televised address to the country on Tuesday night, as Brazil suffered by far its heaviest day of losses since the outbreak began last February.”
3) ““What I see before me is a country that attaches no value to the lives of its citizens,” the scientist and broadcaster Átila Iamarino said of his government’s response.
Devastating record of 3251 new #COVID19 deaths in a single 24 hours were recorded in Brazil 🇧🇷 today. This spike is 40% higher than recent 7 day average. Hospitals overwhelmed. Bolsonaro today also quietly installed his 4th health minister in a year. 🧵 cnnbrasil.com.br/saude/2021/03/…
2) Brazil’s population is roughly 2/3 of the US. Thus, if adjusting Brazil’s 3251 deaths today to a US sized population, this would be equivalent to ~4800 deaths if Brazil had US pop.
3) Don’t look away. The world needs to face the reality of the crisis facing the people of Brazil, and the crushing effects of the #P1 variant, which is also now circulating worldwide as well as neighboring countries. This could all be us if we don’t collectively act.
THIS IS WILD—the NIH is expressing “concern” about information released by AstraZeneca on initial #COVID19 vaccine trial data. “AstraZeneca may have included outdated information from trial, which may have provided an incomplete view of the efficacy data” nih.gov/news-events/ne…
2) Yeah, NYT picked up on this NIH statement released just **after midnight** (unusual in itself). nytimes.com/2021/03/22/wor…
3) “Companies sponsoring drug or vaccine trials typically wait for the monitoring board to run analyses and conclude that the study has yielded an answer before they announce trial results....”