Thread by @TumorBoardTues

#TumorBoardTuesday

That was a super🦸high energy⚡️ @TumorBoardTues case discussion led by @AJacomeMD

🙏for joining

➡️Here is this week's Thursday Case🎀

👉👉Don't forget to pick up your🆓#CME credit by answering these 2 quick❓s

Here's the post-test🔗
integrityce.com/posttest3-23

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

We had an great discussion about gastric cancer, and FGFR-fusions

We captured as much as we could in this moment:
twitter.com/i/events/13739…

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

@AJacomeMD presented a case of a young patient with metastatic gastroesophageal cancer

🔬Poorly-diff adenoca, signet-ring cells, pMMR, HER2-, CPS 0

Most of us would have recommended FOLFOX

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

👍Great🗣️about tumor markers in #gastriccancer - ✅Most chose to follow CEA or CA 19-9 if either was⬆️at baseline

@HHampel1 also taught us that 14.9% of gastroesophageal patients harbor germline pathogenic mutations😲

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

@MPishvaian ❓about➕ing an anti-PD-1 Ab to 1st line Tx in a pt with a CPS=0 tumor❓

A great🗣️between @DocCatenacci @rcarvalhoonco @YJanjigianMD reminded us that no one has👁️that data yet - don't be tricked by the🌲plot😉

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

➡️The patient did very well, but unfortunately had progressive disease with new disseminated bone lesions, confirmed by biopsy

So we were asked - what would you use as second line therapy❓

➡️Most picked ram-tax

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

The❓also came⬆️about surgery for an exceptionally responding patient.
@SyedAAhmad5 @FlavioRochaMD @oncologician & @NirajGusani weighed in:
➡️Only in VERY selected cases

But, there is a trial!

clinicaltrials.gov/ct2/show/NCT03…

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

@AJacomeMD shared the NGS🧬test results

Somatic tumor testing:
💡FGFR2 fusion (-HTRA1 partner)
👉ATM pathogenic mut
🤔TP53 R337C

👏Every one was excited to use an FGFRi & the pt started a clinical trial with erdafitinib

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

We closed out with an excellent mini-tweetorial from @AJacomeMD

➡️As usual, I can't do justice to the teaching, other than to link the tweets😁⬇️⬇️⬇️

https://twitter.com/AJacomeMD/status/1374520188272439297?s=20

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

https://twitter.com/AJacomeMD/status/1374521127062532096?s=20

#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

https://twitter.com/AJacomeMD/status/1374521325209841668?s=20