1/8 #TumorBoardTuesday
➡️This week's Thurs Case🎀 is here!
🔬We discussed locally advanced #PancreaticCancer--& sig of germline muts (ATM). @SirohiBhawna takes us on her pt’s treatment journey.
🗝️insights 🤔on locally advanced #PANCAN below!
#PancreaticCancerAwarenessMonth
➡️This week's Thurs Case🎀 is here!
🔬We discussed locally advanced #PancreaticCancer--& sig of germline muts (ATM). @SirohiBhawna takes us on her pt’s treatment journey.
🗝️insights 🤔on locally advanced #PANCAN below!
#PancreaticCancerAwarenessMonth
1.5/8 #TumorBoardTuesday
👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick❓
Here’s the post-test 🔗: bit.ly/3ws480C
ALL CME 🔗: integrityce.com/tbt Now...on to the case!
👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick❓
Here’s the post-test 🔗: bit.ly/3ws480C
ALL CME 🔗: integrityce.com/tbt Now...on to the case!
2/8 #TumorBoardTuesday
Thurs Case🎀
11/09/2021
Take🏠:
✅Upfront tx depends on pt- mFFX vs gem/nab-pac
✅Test all #PDAC for germline mut regardless of FH!‼️
✅Screen w annual MRI/EUS in gATM
✅Emerging 💊combos tx ATM-mut
✅#PANCAN req multi-D- role for palliative SBRT, ?IRE
Thurs Case🎀
11/09/2021
Take🏠:
✅Upfront tx depends on pt- mFFX vs gem/nab-pac
✅Test all #PDAC for germline mut regardless of FH!‼️
✅Screen w annual MRI/EUS in gATM
✅Emerging 💊combos tx ATM-mut
✅#PANCAN req multi-D- role for palliative SBRT, ?IRE
2.5/8 #TumorBoardTuesday
📚We captured as much of @SirohiBhawna’s discussion, taking us through treatment of locally advanced #PDAC #LAPDAC as we could in this moment: twitter.com/i/events/14585…
📚We captured as much of @SirohiBhawna’s discussion, taking us through treatment of locally advanced #PDAC #LAPDAC as we could in this moment: twitter.com/i/events/14585…
3/8 #TumorBoardTuesday
Thursday Case🎀
11/09/2021
@SirohiBhawna presented a case of a 64 yo w locally advanced #PancreaticCancer (LAPAC) with PMH ovarian ca.
➡️There was a debate between mFFX vs gem/nab-pac
✅But, surprisingly 87% voted for mFFX!
Thursday Case🎀
11/09/2021
@SirohiBhawna presented a case of a 64 yo w locally advanced #PancreaticCancer (LAPAC) with PMH ovarian ca.
➡️There was a debate between mFFX vs gem/nab-pac
✅But, surprisingly 87% voted for mFFX!
4/8 #TumorBoardTuesday
Thursday Case🎀
11/09/21
LAPACT trial✅gem/nab-pac IS option
Retro👀 at gem/nab-pac vs mFFX➡️mFFX assoc w⬆️ORR, but=OS
@FogacciJoao presented another📄:gem/nab-pac better OS @ 1y, mFFX better @ 2y
pubmed.ncbi.nlm.nih.gov/31953079/
jamanetwork.com/journals/jamas…
Thursday Case🎀
11/09/21
LAPACT trial✅gem/nab-pac IS option
Retro👀 at gem/nab-pac vs mFFX➡️mFFX assoc w⬆️ORR, but=OS
@FogacciJoao presented another📄:gem/nab-pac better OS @ 1y, mFFX better @ 2y
pubmed.ncbi.nlm.nih.gov/31953079/
jamanetwork.com/journals/jamas…
5/8 #TumorBoardTuesday
Thurs Case🎀
11/09/2021
Pt starts mFFX➡️sxs👍, CA 19-9⬇️ ,
But😱peripheral neuropathy!
🤔What now❓
Tx break vs FOLFIRI vs 5FU/Cape❓
💡PANOPTIMOX✅maintenance 5-FU..but in met dz
➡️tx break...but ca progresses locally
➡️Chemo vs local tx next❓
Thurs Case🎀
11/09/2021
Pt starts mFFX➡️sxs👍, CA 19-9⬇️ ,
But😱peripheral neuropathy!
🤔What now❓
Tx break vs FOLFIRI vs 5FU/Cape❓
💡PANOPTIMOX✅maintenance 5-FU..but in met dz
➡️tx break...but ca progresses locally
➡️Chemo vs local tx next❓
6/8 #TumorBoardTuesday
Thurs Case🎀
11/09/21
Role of local tx still under🕵️:
LAP-07- no OS benefit of XRT
SBRT palliative benefits❓
Irreversible electroporation (IRE) - highly controversial
Pt tx w XRT⚡️5 mo PFS! But Dz progresses--ctDNA shows ATM mut
pubmed.ncbi.nlm.nih.gov/27139057/
Thurs Case🎀
11/09/21
Role of local tx still under🕵️:
LAP-07- no OS benefit of XRT
SBRT palliative benefits❓
Irreversible electroporation (IRE) - highly controversial
Pt tx w XRT⚡️5 mo PFS! But Dz progresses--ctDNA shows ATM mut
pubmed.ncbi.nlm.nih.gov/27139057/
7/8 #TumorBoardTuesday
Thurs Case🎀
11/09/2021
Which ➡️@SirohiBhawna’s mini-🐦 about ATM & #PANCAN
✅Germline testing for all #PDAC!
✅Screen pts w germline ATM mut for #PDAC
-- Annual MRI vs EUS
✅Screen in pts with BRCA muts- pt centered decision
pubmed.ncbi.nlm.nih.gov/30689033/
Thurs Case🎀
11/09/2021
Which ➡️@SirohiBhawna’s mini-🐦 about ATM & #PANCAN
✅Germline testing for all #PDAC!
✅Screen pts w germline ATM mut for #PDAC
-- Annual MRI vs EUS
✅Screen in pts with BRCA muts- pt centered decision
pubmed.ncbi.nlm.nih.gov/30689033/
8/8 #TumorBoardTuesday
Thursday Case🎀
11/09/2021
🙏 Need better 🧰 for ATM mut PDAC
➡️ Combo ATR + PARP 💊 ❓
🤔 All ATM (or dMMR, or MSI) are 🚫created=
🤩Stay tuned for an EXCITING announcement about the next #TumorBoardTuesday!!
You won’t want to miss what’s in store!
Thursday Case🎀
11/09/2021
🙏 Need better 🧰 for ATM mut PDAC
➡️ Combo ATR + PARP 💊 ❓
🤔 All ATM (or dMMR, or MSI) are 🚫created=
🤩Stay tuned for an EXCITING announcement about the next #TumorBoardTuesday!!
You won’t want to miss what’s in store!
#PostTest Q1️⃣ #CME #TumorBoardTuesday
@SirohiBhawna presented a case of ATM mutated #PancreaticCancer
🤔Which germline testing 🧪is indicated in patients with pancreatic cancer❓
👉🏽posttest🔗 bit.ly/3ws480C
👉🏽ALL CME🔗 integrityce.com/tbt
@MPishvaian #OncTwitter
@SirohiBhawna presented a case of ATM mutated #PancreaticCancer
🤔Which germline testing 🧪is indicated in patients with pancreatic cancer❓
👉🏽posttest🔗 bit.ly/3ws480C
👉🏽ALL CME🔗 integrityce.com/tbt
@MPishvaian #OncTwitter
#PostTest Q2️⃣ #CME #TumorBoardTuesday

🤔What proportion of #PancreaticCancer patients harbor an actionable somatic or germline mutation❓
👉🏼post-test 🔗: bit.ly/3ws480C
👉🏼ALL CME 🔗: bit.ly/TBTxCME
#PanCan #PancreaticCancerAwarenessMonth @MPishvaian

🤔What proportion of #PancreaticCancer patients harbor an actionable somatic or germline mutation❓
👉🏼post-test 🔗: bit.ly/3ws480C
👉🏼ALL CME 🔗: bit.ly/TBTxCME
#PanCan #PancreaticCancerAwarenessMonth @MPishvaian
• • •
Missing some Tweet in this thread? You can try to
force a refresh
