Discover and read the best of Twitter Threads about #PANCAN
Most recents (7)
@TumorBoardTues 1/15 #TumorBoardTuesday #PanCan #OncTwitter
46yo 👩🏻 asymptomatic
no comorb
🌀Screening abd US: liver nodules + pancreatic mass (body/tail)
🔬Liver bx + NET G2 Ki67 12%
🩻PET-Ga + uptake in pancreas & liver (SUVs>20)
💉1L: Lanreotide SC - DP liver after 1y (⬆️volume)
🤨What 2L tx?
46yo 👩🏻 asymptomatic
no comorb
🌀Screening abd US: liver nodules + pancreatic mass (body/tail)
🔬Liver bx + NET G2 Ki67 12%
🩻PET-Ga + uptake in pancreas & liver (SUVs>20)
💉1L: Lanreotide SC - DP liver after 1y (⬆️volume)
🤨What 2L tx?
@TumorBoardTues 2/15 #TumorBoardTuesday
👩🏻 starts 2L CAPTEM: major partial response🙏🏼
🔪Pancreatectomy + R0 liver resections
🔬Path: NET G3 Ki67 90%
🗓️2 mo later
back pain + weight loss: large retroperitoneal LN
💉3L: rechallenge CAPTEM ➡️ poor clinical control 🔀 Cisplatin + Etoposide
👩🏻 starts 2L CAPTEM: major partial response🙏🏼
🔪Pancreatectomy + R0 liver resections
🔬Path: NET G3 Ki67 90%
🗓️2 mo later
back pain + weight loss: large retroperitoneal LN
💉3L: rechallenge CAPTEM ➡️ poor clinical control 🔀 Cisplatin + Etoposide
@TumorBoardTues 3/15 #TumorBoardTuesday #NETCancer @RachelRiechelm2 @MPishvaian @JohnEbbenMDPhD
👩🏻 DP mediastinal LN after 6 mo
💉4L: FOLFIRINOX with partial response/severe toxicity
📑NGS (Foundation One): very high TMB 97 MSS
🧐What 5L tx would you pick?
👩🏻 DP mediastinal LN after 6 mo
💉4L: FOLFIRINOX with partial response/severe toxicity
📑NGS (Foundation One): very high TMB 97 MSS
🧐What 5L tx would you pick?
@TumorBoardTues @JenniferLitton 1/18 #TumorBoardTuesday #BreastCancer #OncTwitter
32 yo 👩🏽
4 months post-partum
🚫comorbidities
FHx paternal uncle with #PanCan
🔬Bx: L breast mass - IDC, G3, ER 50%, PR 30%, HER2 0, Ki67 30%
Clinically node+; FNA confirms LN involvement
🚫 e/o metastatic dz
🤔Do all EXCEPT?
32 yo 👩🏽
4 months post-partum
🚫comorbidities
FHx paternal uncle with #PanCan
🔬Bx: L breast mass - IDC, G3, ER 50%, PR 30%, HER2 0, Ki67 30%
Clinically node+; FNA confirms LN involvement
🚫 e/o metastatic dz
🤔Do all EXCEPT?
@TumorBoardTues @JenniferLitton 2/18 #TumorBoardTuesday #BCSM @JenniferLitton
🧬 testing returns with BRCA2 path variant
✂️ L mastectomy and ALND
Right risk ⬇️ mastectomy
Found to have 8+/15 LNs
Undergoes adjuvant AC/T
🤔After referring to ☢️ XRT, you discuss which of these treatments?
ET= AI+OS vs Tamoxifen
🧬 testing returns with BRCA2 path variant
✂️ L mastectomy and ALND
Right risk ⬇️ mastectomy
Found to have 8+/15 LNs
Undergoes adjuvant AC/T
🤔After referring to ☢️ XRT, you discuss which of these treatments?
ET= AI+OS vs Tamoxifen
@TumorBoardTues @JenniferLitton @JasmineSukumar @Dr_RShatsky @awolff @jane_meisel @sardesai_sagar @andMORand @MassimoDiMaio75 @MLambouras @melindatelli @IBCradiation @TJH0828 @naborala @MuozMateu @FadwaARahman @emrekocamd @spinmaplered @LeandroJonatad1 @crisonco @adrianakahnmd @MamMa_mimumemo @LauBuisseret
#TBTWebinar is back ‼️
🥼 @MPishvaian @BreastCancerMD1 @Latinamd @BenWestphalen
#CME🔗 bit.ly/3vdXBb4
Pretest 👉 bit.ly/3rYNZir
Claim credit 👉 bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc
twitter.com/i/broadcasts/1…
🥼 @MPishvaian @BreastCancerMD1 @Latinamd @BenWestphalen
#CME🔗 bit.ly/3vdXBb4
Pretest 👉 bit.ly/3rYNZir
Claim credit 👉 bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc
twitter.com/i/broadcasts/1…
#TumorBoardTuesday HER2 #TBTWebinar 🔑
➡️HER2 activity requires receptor dimerization
✅HER1 = EGFR
✅HER3, HER4
➡️HER2 is frequently overexpressed in multiple cancers
✅Protein⬆️due to gene🧬 amplification
✅Constitutive activation due to activating🧬mutation
➡️HER2 activity requires receptor dimerization
✅HER1 = EGFR
✅HER3, HER4
➡️HER2 is frequently overexpressed in multiple cancers
✅Protein⬆️due to gene🧬 amplification
✅Constitutive activation due to activating🧬mutation
#TumorBoardTuesday HER2 #TBTWebinar 🔑
➡️HER2 (ERBB2) alterations occur in multiple cancer types
✅Breast Ca 25%
✅Gastric Ca 22%
✅GE jxn Ca 32%
✅CRC 5%
✅Lung Ca 6 to 30%
✅Biliary Ca 5 to 20%
🤔There is some disease specificity re: overexpression vs activating🧬mutation
➡️HER2 (ERBB2) alterations occur in multiple cancer types
✅Breast Ca 25%
✅Gastric Ca 22%
✅GE jxn Ca 32%
✅CRC 5%
✅Lung Ca 6 to 30%
✅Biliary Ca 5 to 20%
🤔There is some disease specificity re: overexpression vs activating🧬mutation
1/8 #TumorBoardTuesday
➡️This week's Thurs Case🎀 is here!
🔬We discussed locally advanced #PancreaticCancer--& sig of germline muts (ATM). @SirohiBhawna takes us on her pt’s treatment journey.
🗝️insights 🤔on locally advanced #PANCAN below!
#PancreaticCancerAwarenessMonth
➡️This week's Thurs Case🎀 is here!
🔬We discussed locally advanced #PancreaticCancer--& sig of germline muts (ATM). @SirohiBhawna takes us on her pt’s treatment journey.
🗝️insights 🤔on locally advanced #PANCAN below!
#PancreaticCancerAwarenessMonth
1.5/8 #TumorBoardTuesday
👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick❓
Here’s the post-test 🔗: bit.ly/3ws480C
ALL CME 🔗: integrityce.com/tbt Now...on to the case!
👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick❓
Here’s the post-test 🔗: bit.ly/3ws480C
ALL CME 🔗: integrityce.com/tbt Now...on to the case!
2/8 #TumorBoardTuesday
Thurs Case🎀
11/09/2021
Take🏠:
✅Upfront tx depends on pt- mFFX vs gem/nab-pac
✅Test all #PDAC for germline mut regardless of FH!‼️
✅Screen w annual MRI/EUS in gATM
✅Emerging 💊combos tx ATM-mut
✅#PANCAN req multi-D- role for palliative SBRT, ?IRE
Thurs Case🎀
11/09/2021
Take🏠:
✅Upfront tx depends on pt- mFFX vs gem/nab-pac
✅Test all #PDAC for germline mut regardless of FH!‼️
✅Screen w annual MRI/EUS in gATM
✅Emerging 💊combos tx ATM-mut
✅#PANCAN req multi-D- role for palliative SBRT, ?IRE
1/12 #TumorBoardTuesday
Thurs 10/12/21 Case🎀
@ShaalanBeg @CancerCommons present a case of #PancreaticCancer that challenges us to🤔about cell signaling & mol bio➡️better outcomes.
📚We captured as much of the chat as we could:
twitter.com/i/events/14479…
#PanCan #KRAS #OncTwitter
Thurs 10/12/21 Case🎀
@ShaalanBeg @CancerCommons present a case of #PancreaticCancer that challenges us to🤔about cell signaling & mol bio➡️better outcomes.
📚We captured as much of the chat as we could:
twitter.com/i/events/14479…
#PanCan #KRAS #OncTwitter
2/12 #TumorBoardTuesday
Thurs Case🎀
Take🏠messages:
We discussed #PancreaticCancer & specific #KRAS mut
✅All KRAS muts aren’t ≠
✅KRAS G12R➡️⬆️autophagy
✅Autophagy= tumor can♻️cell components ➡️resistance
✅MEKi + autophagy inhib= strat for G12R
✅Repeat NGS on prog is🗝️!
Thurs Case🎀
Take🏠messages:
We discussed #PancreaticCancer & specific #KRAS mut
✅All KRAS muts aren’t ≠
✅KRAS G12R➡️⬆️autophagy
✅Autophagy= tumor can♻️cell components ➡️resistance
✅MEKi + autophagy inhib= strat for G12R
✅Repeat NGS on prog is🗝️!
3/12
#TumorBoardTuesday
Thursday Case🎀
👉👉 Don’t forget to pick up 🆓 #CME credit by answering 3 quick ❓
Here is the post-test 🔗: bit.ly/3Bzgply
ALL CME 🔗: integrityce.com/tbt
#TumorBoardTuesday
Thursday Case🎀
👉👉 Don’t forget to pick up 🆓 #CME credit by answering 3 quick ❓
Here is the post-test 🔗: bit.ly/3Bzgply
ALL CME 🔗: integrityce.com/tbt
#TumorBoardTuesday
💥Wow - this week was TOO much‼️
A🗣️on TMB-high #PancreaticCancer & #Immunotherapy by @DrBonillaOnc
AND our 1st pt-directed🗣️led by @HPolymenis and @StephenVLiu
👉Don’t forget your🆓#CME credit-answer 3 quick❓
Here's the postest🔗
surveymonkey.com/r/6JVHCSG
💥Wow - this week was TOO much‼️
A🗣️on TMB-high #PancreaticCancer & #Immunotherapy by @DrBonillaOnc
AND our 1st pt-directed🗣️led by @HPolymenis and @StephenVLiu
👉Don’t forget your🆓#CME credit-answer 3 quick❓
Here's the postest🔗
surveymonkey.com/r/6JVHCSG
#TumorBoardTuesday
Thursday Case🎀
(Case from 06/01 and 06/02/21)
We discussed #PancreaticCancer and:
✅Cynicism/Nihilism
✅The importance of multi-D care
✅1st line Tx
✅🧬Testing
✅#Immunotherapy
We captured as much as we could in this moment:
twitter.com/i/events/13999…
Thursday Case🎀
(Case from 06/01 and 06/02/21)
We discussed #PancreaticCancer and:
✅Cynicism/Nihilism
✅The importance of multi-D care
✅1st line Tx
✅🧬Testing
✅#Immunotherapy
We captured as much as we could in this moment:
twitter.com/i/events/13999…
#TumorBoardTuesday
Thursday Case🎀
(Case from 06/01 and 06/02/21)
And also this moment:
twitter.com/i/events/14005…
Thursday Case🎀
(Case from 06/01 and 06/02/21)
And also this moment:
twitter.com/i/events/14005…
#PancChat #TumorBoardTuesday
💥A truly unique TBT w/ a hybrid🗣️on BRCA-mut Panc Ca with @letswinpc @drallysonocean & @TumorBoardTues
➡️Here is this week's Thursday Case🎀
👉👉And pick up your🆓#CME credit by answering 2 quick❓
Here is the post-test🔗
surveymonkey.com/r/GBYGYB2
💥A truly unique TBT w/ a hybrid🗣️on BRCA-mut Panc Ca with @letswinpc @drallysonocean & @TumorBoardTues
➡️Here is this week's Thursday Case🎀
👉👉And pick up your🆓#CME credit by answering 2 quick❓
Here is the post-test🔗
surveymonkey.com/r/GBYGYB2
#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)
We🗣️a lot about #PancreaticCancer including:
✅Delays to Dx
✅Choosing NOT to have chemo
✅Universal🧬testing
✅BRCA mut & PARP inh
We captured as much as we could in these two moments:
twitter.com/i/events/13838…
Thursday Case🎀
(Case from 04/20/21)
We🗣️a lot about #PancreaticCancer including:
✅Delays to Dx
✅Choosing NOT to have chemo
✅Universal🧬testing
✅BRCA mut & PARP inh
We captured as much as we could in these two moments:
twitter.com/i/events/13838…
#PancChat #TumorBoardTuesday
Thursday Case🎀
(Case from 04/20/21)
And this moment too:
twitter.com/i/events/13838…
Thursday Case🎀
(Case from 04/20/21)
And this moment too:
twitter.com/i/events/13838…
