An intriguing preprint (modelling study by LSHTM) just out: "Within and between classroom transmission patterns of seasonal influenza and implications for pandemic management strategies at schools"
1/
assets.researchsquare.com/files/rs-32236…
Simulations suggest⬇️class sizes may not be effective in⬇️risk of major school outbreaks, possibly due to contact behaviour between students i.e. students may have certain no. of ‘close friends’ with whom they have more interactions that could facilitate transmission.
2/
They suggest 2 approaches. Pre-emptive approach eg symptom screening, regular tests, ⬇️outside-class interactions & intermittent schooling. Or Responsive approach - single class closure where there's a case, but need to detect outbreak early before spreads outside the class.
3/
The researchers suggest regular testing + responsive approach not cost-effective for COVID-19 because isolating only test-positive students (without
class closure) was predicted to achieve similar outcomes with minimal loss in education opportunity.

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More from @andrewleedr

19 Feb
On a lighter note this weekend, let me tell you the story of a (not so secret) service dedicated to protecting the human population from aliens.
1/

(They don't usually dress like that btw with exception of maybe @antmikeg & @Smithkjj )
And by aliens I mean the bug kind...

(Sometimes real biology looks worse than our imagined extra-terrestrial invaders)

If you've not guessed yet I'm referring to Health Protection teams across the UK who deal with communicable diseases & environmental health threats.

2/
HP teams are made up of a diverse lot of professionals: communicable disease control consultants, nurses, practitioners, scientists, epidemiologists, microbiologists, analysts, emergency planners, etc.... that reflect the skill mix required.

3/
Read 13 tweets
18 Feb
Normally I enjoy the high standards of journalism in @guardian . Not today as disappointed with misleading headline that suggest infections are spreading fastest in children. It'll worry parents/teachers & I doubt most readers will unpick the headline.
1/
theguardian.com/world/2021/feb…
The latest REACT1 report shows prevalence of infection in ALL age groups has fallen, including children aged 5-12 from 1.59% in Round 8 to 0.86% in Round 9a. The authors of REACT1 report also (wisely) didn't try to interpret the prevalence figures.
2/
spiral.imperial.ac.uk/bitstream/1004…
If this were a research trial you wouldn't place much weight on the age differences in % prevalence because of the wide confidence intervals, i.e. differences weren't statistically significant.
3/
Read 16 tweets
3 Feb
In the past 15+ yrs I've worked as a GP in some of the poorest parts of Sheffield with all the social ills of poverty: debts, joblessness/job insecurity, crime, abuse, domestic violence, mental ill health, disrupted lives, chronic diseases, alcoholism, early deaths, etc... 1/
For many of my patients, poverty isn't an abstract concept you read about. It's their lived experience. It's real. It's pervasive. It wears you down. It kills your hopes & dreams. And they're trapped in a repeating cycle across generations. 2/
COVID has been really bad for them. Difficult to lockdown in rubbish housing, little greenspace, nowhere to go, nothing to do. Having debts & insecure work forces you to work. I feel most for the kids, many who went to school with my kids, but lack the opportunities mine have. 3/
Read 6 tweets
3 Feb
Our @ScHARRSheffield MPH disaster management class recently looked at the topic of post-disaster recovery. Several key points that will be relevant as we look ahead to the coming months. (I know we are in the thick of pandemic response, but never too early to look ahead!) 1/
It needs to be a managed process that starts the moment an incident has occurred. Not just about rebuilding and recovery, but also has to incorporate prevention/risk reduction measures & preparedness for potential further crisis. 2/
Key to this will be the need for multi-sectoral rapid needs assessments. The population's needs will have changed considerably between pre-disaster and post-disaster. So NHS/LA need to start thinking about doing these RNAs to guide next steps. 3/
Read 11 tweets
17 Jan
I tweeted last week the link to @ECDC_EU evidence review of EU & international evidence on: COVID-19 in children and the role of school settings in transmission. Just finished reading it in full & it's balanced & comprehensive. (1) ecdc.europa.eu/en/publication…
Reiterates finding that children are very unlikely to have severe illness with COVID19 infection. (2)
Shedding of viral RNA thru upper respiratory tract may be of shorter duration in children than in adults. Associated with age, although doesn't appear to be significant difference in levels of viral RNA detected in nasopharyngeal swabs between the two. (3)
Read 16 tweets
10 Oct 20
The number of COVID19 cases in UK continues to rise, with a trajectory that is worryingly becoming steeper. Hospitalisations up. ICU admissions up. Community transmission & outbreaks widespread. Clearly control of the epidemic in the UK is deteriorating. Deaths will follow.
1/
Worth revisiting @acmedsci 's report in July for their predictions. acmedsci.ac.uk/file-download/…
Their predicted real worst case scenario is looking more likely.
Give or take a few weeks, we're in for a difficult winter. What's less clear is just how bad is going to get...
2/
The UK gov has thrown £billions at the problem, hired loads of private consultants & consultancy firms, been given lots of good scientific advice, done national lockdown plus local variants of lockdown lite. Yet it's not working.
3/
Read 8 tweets

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