The number of COVID19 cases in UK continues to rise, with a trajectory that is worryingly becoming steeper. Hospitalisations up. ICU admissions up. Community transmission & outbreaks widespread. Clearly control of the epidemic in the UK is deteriorating. Deaths will follow.
1/
Worth revisiting @acmedsci 's report in July for their predictions. acmedsci.ac.uk/file-download/…
Their predicted real worst case scenario is looking more likely.
Give or take a few weeks, we're in for a difficult winter. What's less clear is just how bad is going to get...
2/
The UK gov has thrown £billions at the problem, hired loads of private consultants & consultancy firms, been given lots of good scientific advice, done national lockdown plus local variants of lockdown lite. Yet it's not working.
3/
Loads of opinions out there as to why our efforts aren't working. Frankly dangerous idea out there too about "letting it rip" & going for herd immunity. Pandemic fatigue setting in. If tighter control measures fail, few options left but another damaging national lockdown.
4/
I think there's been a crucial weakness all along in our approach. It's not the lack of scientific advice but the technical expertise & experience of communicable disease control. This is something @doctorshaib has oft repeated & I agree.
5/
Technical expertise is undervalued, a poor relation to science. But technical experts know how to translate science into action, understand realities on the ground & the detail needed to turn ideas into reality. Without them, science & policy intent are just wishful thinking.
6/
That's why we need our jobbing public health folk, senior health managers & civil servants, the apparatus that makes it happen. Crucially, they can tell if an idea is undoable. Outsourcing to private firms isn't the solution as they often lack that technical expertise.
7/
At regional emergency planning level, we have Scientific & Technical Advisory Cells (STACs). But this isn't replicated at higher decision making level. So what seems to be lacking is that operational nous. Diversity of expertise is needed as you don't know what you don't know.

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More from @andrewleedr

1 Oct
The key to better control of the #covid19 pandemic may be in identifying & preventing #superspreading, through backward tracing to identify clusters. Need to rethink our approach.

Good article by @zeynep explaining the rationale.
theatlantic.com/health/archive…
Contact tracing seeks out where the infection has come from (look for source) & where it is going (contacts of the index who may be susceptible). An assumption is that all infections are equal (i.e. every infected person has a similar chance of infecting someone else).

1/n Image
So with COVID19, we assume with R0=2.6, 1 infected person infects 2.6 others. But this is an erroneous assumption if superspreading is a key mode of transmission. Some infected persons are more infective!

2/n Image
Read 13 tweets
18 Sep
Musings today:

The problem I think with the current approach to COVID19 is we are approaching it the wrong way round, from the wrong end of the telescope.

1/...
COVID19 is a public health problem that requires a public health approach & solution. Trouble is, we often try to solve public health problems with healthcare solutions from a healthcare perspective.

2/...
If you had cancer, it would be nice to have the best cancer diagnostics & treatments. But wouldn’t it be better not to have had cancer in the first place? What if we eliminated smoking & in doing so prevented thousands of cancers?
Similarly, COVID19 is a preventable disease.

3/
Read 9 tweets
3 Sep
#Masstesting especially of asymptomatic individuals for #COVID19 is NOT a magic bullet solution.

There seems to be a lot of clamour for it but we need to consider not just the utility of testing but also the issues with it.
1/...
A few months back a team of public health researchers @FionaBell19 @lliandme @ScHARRSheffield carried out a rapid evidence review on #masstesting. We found the evidence from around the world to be mixed, patchy and limited.
2/...
NO TEST IS PERFECT. PCR tests for COVID19 can’t always tell if it is current infection or past infection, or whether the individual is still infectious or not. Here's where clinical interpretation and judgment is key.
3/...
Read 12 tweets
13 Aug
Early results from PRIEST Study - a multicenter observational cohort study of patients attending UK Emergency Departments.

Profile of ED attenders here:
medrxiv.org/content/10.110…

@ScHARRSheffield
1/...
Adults attending ED with suspected COVID-19 had substantial co-morbidities.

Men more likely to be admitted, have positive COVID-19 testing, require organ support & die.

Reassuringly, children had much lower rates
of admission, COVID-19 positivity, organ support & death .

2/...
Black or Asian adults attending ED tended to be younger than White adults, less likely to have impaired performance status, be admitted to hospital or die, but more likely to require organ support or have a positive COVID-19 test. Comorbidities varied between ethnic groups.
3/..
Read 4 tweets
19 Jul
Currently going round twitter is a worrying @nytimes article that asserts school age children transmit COVID19 as much as adults. It's based on this study from S Korea wwwnc.cdc.gov/eid/article/26…
but I reckon the findings aren't that clear cut.
One issue is directionality. Isn't clear whether it's a case of child transmitting to adult or adult transmitting to child. 2ndly, testing protocols weren't explicit (young children tend to be tested less=skews testing data). Age bands too broad, 10 year olds aren't 19 year olds.
The associations were household & not school level. The study authors have extrapolated household level of risk (~11.8%) to school settings. Whereas non household attack rates where only 1.9%. (Unmitigated) school risk probably sits somewhere between the two but at which end?
Read 4 tweets
14 Jul
Source of this is a report released today by Academy of Medical Science: Preparing for a challenging winter 2019/20.
Sobering reading and a realistic assessment IMHO.
Recovery planning taking place now must incorporate the v real likelihood of a COVID19 + Flu wave in the winter.
They identify 4 challenges:
1. Large resurgence of COVID-19 nationally, + local/regional epidemics. Peak in hospital admissions & deaths Jan/Feb 2021, similar magnitude to 1st wave, coinciding with period of peak demand on NHS. ~119,900 deaths, over double number in 1st wave.
2. Health & social care systems disruptions due to reconfigurations to respond to & reduce transmission of COVID-19 + knock-on effect on ability of NHS to deal with non-COVID-19 care. Remobilisation of resources as per 1st wave unlikely to be possible due to winter pressures etc.
Read 9 tweets

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