New preprint with BC N501Y screening data is out! First time I have seen proper VOC data out in public. Data is old now, but let's take a look what we can learn about data up to week 9, so end of February. medrxiv.org/content/10.110…
Before we go there, the preprint also has this neat summary of the point-prevalence study that @PennyDaflos also wrote about. The data in the preprint is about the left branch, N501Y screening. Positive results are presumed to be VOC. In BC that will be B.1.1.7 in most cases.
There are also some (small) false positives. This shows 1% prevalence of VOC at the beginning of February. This is still news because our PHO has still not corrected this after repeatedly claiming prevalences was 0.1%, and did not correct this even when asked directly.
Our main interest in this preprint is the following table. It shows weekly N501Y screening data with proper dates and denominators. That's exactly what's needed to understand VOC growth. And how VOC and regular COVID have evolved.
Let's add this to our usual graph we have been using to guess at the BC VOC share using Ontario and Denmark as a guide. The trend derived from the data fits out guess trajectories pretty well, although it over-shoots a little. Data lags a lot, but what can you do?
Actually there is something we can do, there was a (public?) BCCDC presentation today where more recent data was presented. (And some older data got re-jigged a bit.) Let's make another curve with that newer data! That moves the curve down to the lower end of our estimates.
End result does not change much, the rise of VOC shares in BC follows the expected pattern. The virus apparently can't tell the difference between Ontario and BC after all. Let's check out the VOC cases derived from the (fitted) VOC share from above. OMG! Exponential Growth!
How exponential. Let's graph this on a log scale just to be sure. For good measure we should throw in points for the times when we had measures of the VOC shares and multiply that with that days case numbers. Yap, very exponential.
Let's look at all cases thus broken out into VOC and non-VOC. What's the story? Looks like the initial decline of regular covid slowed and turned (maybe) into a small increase in early February. And the explosive case growth we have seen? All due to VOCs!
The two grew at different rates. (Duh!) VOCs did not "replace" regular COVID, they added to it. If we had not failed to keep VOCs out, that red part would not have been replaced by the salmon colours regular COVID. It would not be there. At all.
Let's see how the official data in today's Situation Report is keeping up. It added data for week 11 and reports 861 extra VOC cases. At the same time N501Y screening found 1036 presumptive VOC in week 11. Sequencing is not keeping up, and it's just going to get worse.
I don't think the BCCDC presentation or the slides are publicly available (yet?). (And I haven't seen the whole thing either.) If others want the data I have seen, here is a link to the (limited) N501Y data I transcribed from the preprint and the talk. docs.google.com/spreadsheets/d…

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More from @vb_jens

30 Mar
Over a year ago StatCan released the first set of CHS data that showed frighteningly high rates of forced moves in BC. @LausterNa and I dug into recently released PUMF data to add context, see how this varies within BC, and how it has changed over time. doodles.mountainmath.ca/blog/2021/03/2…
This is a follow-up on this over a year old post that looked at forced moved (and other data) from the CHS when the first tables were released. The PUMF data we got now allows to paint a fuller picture. doodles.mountainmath.ca/blog/2019/11/2…
What can be learned about forced moves from PUMF data? Firstly, instead of looking a share of moves that are forced, we can look at risk of forced moves in the past year. And Vancouver comes out in the middle of the pack.
Read 5 tweets
30 Mar
It's Monday, and BC got 4 days worth of data after skipping Friday's update and the usual weekend data blackout. (What pandemic?) And as expected, it's looking bad. The trend is at almost 900 daily cases now.
Vancouver Coastal has now overtaken Fraser with the highest case incidence, and cases are also clearly rising in Island and Interior Health Authorities.
North Shore Garibaldi has the highest incidence in cases, but it's not the only health region with steep increases.
Read 7 tweets
28 Mar
Hey, my favourite Vancouver single family lots are for sale! Lots of stories behind these lots, they have been tossed back and forth between investment companies over the years. The proposed homes look awful and are likely just an attempt to avoid the EHT. squamishchief.com/real-estate-ne…
These lots have featured prominently on the @ahvancouver walking tours of Vancouver's worst zoning. The biggest of the three lots is Vancouver's largest non-sub-dividable RS lot at almost 3 acres in size.
Apart from this being a prime example of how functionally useless some of Vancouver's zoning is, there are great stories connected to those lots. @ahvancouver dug up a lot of neat history, and @ron_usher has great stories about recent investors (and attempted scams).
Read 4 tweets
3 Mar
Lots of discussions on changing the vaccine dose scheduling in BC. I don’t know much about this, so I asked a friend who are directly involved in research and development of (COVID) vaccines. My takeaway:
1. Vaccine trials have a short first/second does schedule, mostly because it accelerates trials and has lower attrition.
2. When asked, vaccine manufacturers will always point to schedule from trails as recommended protocol for liability reasons.
3. We don’t have direct evidence that stretching the time between doses to 4 months is equally effective (after second dose).
4. We have some evidence that first dose already grants a high level of immunity, at least short term.
Read 8 tweets
3 Mar
Today we got 4 days of COVID data plus corrections for a couple days before that. The recent increase in cases is now well established, with a recent flattening in the increase. Will that reverse and continue to increase, or go back to decreasing trend? We shall see.
The big question is what caused this? A super spreader event (triva night?) after which we will see declines again? Variants of concern? Probably too early for such a sharp rise, we would expect to see a rise like this this later this month, not now.
Fraser and Vancouver Coastal are driving the recent trend, Interior has come down nicely and Northern also seems to wiggle their way down. Island is still on their path of slow increases.
Read 6 tweets
31 Jan
A rater niche and slightly geeky look at trend lines in general and COVID-19 case trends in particular. I got nerd-sniped a while back by @chadskelton to write this up, and also had discussions with @tom_cardoso and @robroc about this. doodles.mountainmath.ca/blog/2021/01/3…
TL;DR: Trend lines are an important tool to filter noise from signal. Moving averages is one way to do this, but it's not good at removing noise and introduces a data lag. Using methods like STL that can account for the weekly pattern and don't add extra data lag are preferable.
Moving average trend lines do have the advantage that they are simple to understand, but get misleading when they are artificially shifted to the right to obscure the data lag. This problem is particularly acute when overlaid over case counts as for example in this graph.
Read 5 tweets

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