Thread by @MonicaGandhi9

I have idea that could decrease cases right now in states that have increasing cases, which is to switch to giving out the 1st dose now & wait on 2nd dose to immediately expand number vaccinated in each of those states now. Let me explain: map of US cases
nytimes.com/interactive/20…

Here is the WaPo tracking site on vaccination rates by county. 4 reasons for giving 1st dose now in those counties & waiting on 2nd are 1) "Based on immunologic principles, sensitization with single doses would still allow boosting with a 2nd dose
washingtonpost.com/graphics/2020/…

several months later" (please see great Dr. Plotkin article). 2) "B-cell memory after mRNA vaccination has been clearly demonstrated, which supports the idea that antibodies will be boosted by a second mRNA dose given months later" (remember B cell paper)
academic.oup.com/cid/advance-ar…

3) "Priming of the immune system generates good responses to second doses of most vaccines for at least 6 months and perhaps longer" 4) "three doses of hepatitis B vaccines administered at yearly intervals were equally effective as the recommended 1-, 2-, and 6-week schedule".

The AZ vaccine shows us that longer between doses the better for immunogenicity & shouldn't be any different for mRNA or J&J vaccines.

And finally, a really nice article that explains to us that giving 1 dose now and 2nd later won't make virus more likely to escape immune response but, instead, will "slow the rate of viral escape from vaccine or naturally induced immunity".
nature.com/articles/s4157…

@threadreader unroll