My mind is blown. Have T cells been false idols all along?
@MLevitt_NP2013,@MonicaGandhi9 come quick-
CD4, CD8, and CD4/8 depletion in Macaques prior and during infection did not affect disease course and only mildy attenuated viral clearance! biorxiv.org/content/10.110…
@MLevitt_NP2013,@MonicaGandhi9 come quick-
CD4, CD8, and CD4/8 depletion in Macaques prior and during infection did not affect disease course and only mildy attenuated viral clearance! biorxiv.org/content/10.110…
This is important work, and is part of the reason why I say t cells don't matter so much in this disease...
https://twitter.com/fitterhappierAJ/status/1321086817228173313
embopress.org/doi/full/10.15… Antibodies opsonize infected cells, which can then be cleaned up.
This is all thanks to the tricky spike protein that goes to the surface of cells and exposes itself.
This is the work of @Timothee_B
This is all thanks to the tricky spike protein that goes to the surface of cells and exposes itself.
This is the work of @Timothee_B
https://twitter.com/fitterhappierAJ/status/1329681558379302912
So this means, we are able to clear infected cells that express spike on their surface in the absence of CD8 T cells or MHC. It is why antibodies are more important, in my opinion.
https://twitter.com/fitterhappierAJ/status/1366100831045566465
Does this mean the finding where @Anto_Berto
shows the t cells exist is not required for control?
shows the t cells exist is not required for control?
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