On the contrary, we should worry about variants "escaping" CD8+ immunity, especially if one has HLA:24

I am surprised- maybe we are awaiting publication? @NahasNewman

As of yet this sort of escape has been mostly theoretical. biorxiv.org/content/10.110…
When we lose CD8 reactivity, we lose our ability to cull infected cells. 😱

Something we were promised so frequently would not happen, but it did! @zeynep
They were warned in a light way, but it didn't get through 😔

This is my biggest fear manifest, and what did the AIER/Pandata/GBD crowd do? they passaged the virus in schools per Azar 😰
The myth accepted by those susceptible to dogmatic memorisation rather than conceptualisation was that it would become less virulent with passage @MLevitt_NP2013

What a shame.

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Anthony J Leonardi

Anthony J Leonardi Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @fitterhappierAJ

6 Apr
1/ I see you raised it in March @MLevitt_NP2013 but as the saying goes, what goes up must come down

The work dashes X reactive T cells- they poorly proliferate in the few people that possess them.

X reactive abs, as your image queries, are equally rare ImageImageImage
2/ Why the focus on T cells? We have yet to see any protective effect of T cell memory without antibodies from infection.

Rather, it is sera which is seen to exert a protective effect after recovery, not T cells alone. medrxiv.org/content/10.110… In regard to the paper... Image
3/ We must also understand that T cells do not exert immunity prior to any sort of infection, unless they 'see' antigen from an exposure/vaccine.

The fact the T cells have responded, means indeed there was a viral challenge, and the cells 'saw' antigen. So let's look... Image
Read 6 tweets
5 Apr
I can't believe what I'm seeing. Is this late April Fool's @MLevitt_NP2013??

My mind is blown again.

I'm about to hang up the T cell towel. The emperor has no clothes!

Only 2/30 donors have cross reactive Tcells and they don't proliferate much at all! nature.com/articles/s4146… ImageImageImageImage
*of healthy donors
This is in total contrast to this paper here with James Todaro's tweet. We are rewriting history!
Read 4 tweets
4 Apr
My mind is blown. Have T cells been false idols all along?

@MLevitt_NP2013,@MonicaGandhi9 come quick-

CD4, CD8, and CD4/8 depletion in Macaques prior and during infection did not affect disease course and only mildy attenuated viral clearance! biorxiv.org/content/10.110… ImageImageImage
This is important work, and is part of the reason why I say t cells don't matter so much in this disease...
embopress.org/doi/full/10.15… Antibodies opsonize infected cells, which can then be cleaned up.

This is all thanks to the tricky spike protein that goes to the surface of cells and exposes itself.

This is the work of @Timothee_B
Read 5 tweets
30 Mar
There's always good news about T cells and Cov2, but now it's time for Fascinating news.

We see lots of articles about conserved T cell recognition of variants, but we must include Cov2 is a 🤓 genius only getting more learnéd.

Cov2 has a protein that takes down MHC 1! 🧵
MHC 1 is how T cells 'see' infected cells. Orf8 is a protein that 'takes down' MHC 1, meaning it helps cov2 'hide.'

You can upregulate interferon to fight this, but guess what... pnas.org/content/118/2/…
...the next genius way to hide from T cells is by inducing an interferon antibody!

Interferon is important for upregulating MHC for T cell recognition. Somehow, Cov2 is able to cause your body to block its own process! Brilliant! nature.com/articles/d4158…
Read 7 tweets
29 Jan
I've been comparing cov2 to ebola ever since I saw the lymphopenia in Jan in the Lancet. Nasty damn bug. Confuses the hell out of the immune system. theguardian.com/society/2021/j…
I really enjoy looking into Ebola, because when I started out at the NCI we had a phenomenon where we did not know the mechanism
Basically, a talented Physician before I arrived noticed memory T cells in a stimulation would differentiate pools of t cells further pubmed.ncbi.nlm.nih.gov/20971955/
Read 16 tweets
28 Jan
The propaganda is ramping up to pressure admin to open schools. It's based on an interpretation where they look at an exceptional single case in rural wisconsin and ignore the preponderance of evidence about the ability of spread in schools elsewhere.
It's not safe or just to put people in classrooms where they risk long covid, variants, and do not have vaccine protection. If you want kids in classrooms fund the trials and get kids a vaccine. China is doing it. Get with the program! reuters.com/article/us-hea…
putting children in situations where 1/X of them have reactions like this is unfair. We can judge a society by how they treat the infirm, yes, but how about the society which also protects the so called 'least vulnerable?' Covid-19 is not only an acute huffingtonpost.co.uk/entry/long-cov…
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!