Clinical syndrome rare blood clots temporally associated vaccination but not proven to be causally related must be taken seriously & investigated with an open mind. ft.com/content/45cb34…
Meanwhile follow guidance of independent regulators @MHRAgovuk @EMA_News @WHO who in my view rightly recommend continued vaccine use in all adults
A hypothesis to be tested with studies & data. The rare clinical syndrome temporally related to vaccination is remarkably similar to a clinical syndrome of central venous thrombosis seen after SARS-COV2 infection reported in multiple case reports & series ajnr.org/content/early/…
The Spike protein/RBD in the virus in natural infection & expressed post vaccination leads to a very rare syndrome, mediated thru binding Spike/RBD to endothelium (or possibly clotting cascade) leading to very rare clinical syndrome. Fall in platelets is secondary to the clotting
Hypothesis - the mechanism, the pathogenesis of the rare central venous thrombosis is the same following natural infection & vaccination. The risks being very much greater after infection, hence the benefits hugely in favour of vaccination theguardian.com/world/2021/apr…
Open mind = exploring all possibilities-a shared mechanism leading to a similar clinical syndrome associated with natural infection & vaccination or a different one.But seems odd that such a rare syndrome seen after infection & possibly post vaccine does not have common mechanism
What is common to both natural infection & vaccine? The Spike/RBD not the vaccine vector delivery system.

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More from @JeremyFarrar

18 Feb
Audio Interview: Viral Variants and Covid-19 | NEJM nejm.org/doi/full/10.10…
During the discussion I was reminded of another podcast from May 2019 @NEJM - Haunting to listen to now "Emergence & spread of new infectious diseases and ensuring swift, coordinated action in the face of threats." podcasts.apple.com/ca/podcast/nej…
And the accompanying editorial "Stopping the Gaps in Epidemic Preparedness" nejm.org/doi/full/10.10…
Read 4 tweets
31 Jan
Until we are all safe, no one is safe. Covid is a global problem ⁦@RobinMcKietheguardian.com/world/2021/jan…
It is reasonable & understandable for countries to roll out vaccines to vulnerable people & #HCW within country. But at the same time ensure that vaccines are made available urgently & equitably globally through ACT-A, @WHO, @GAVI & @CEPIvaccines
That needs intense planning, manufacturing at scale, trust, communication, logistics, people & teams, regulation, approvals, cold chains. That does not happen overnight. Urgent planning now for when vaccines are available is crucial.
Read 8 tweets
29 Jan
An honour to give opening remarks & join ⁦@UN⁩ Govt ⁦@Canada⁩ ⁦@CIHR_IRSC⁩ & colleagues around world on launch of Research Roadmap & Science for Development in Context COVID19. Remarks from inspirational ⁦@AminaJMohammed⁩ DSG @UN un.org/webcast/schedu… Image
COVID-19 has exposed stark global inequities, fragilities & unsustainable practices that pre-date this pandemic & have intensified its impact. Please see full report un.org/en/coronavirus…
This @UN Research Roadmap for COVID-19 Recovery provides a framework for leveraging the power of science in support of a better socio-economic recovery and a more equitable, resilient and sustainable future.
Read 6 tweets
2 Jan
World needs to know. A text this evening from colleague in middle income country. "We have a disaster here. Hospitals overwhelmed, critical oxygen shortages, soaring COVID numbers. New variant SARS- COV-2 highly transmissible"
"Know vaccines not magic bullet but are critical part of pandemic response. We need them now. #HCW exhausted, on their knees. Need vaccine urgently & are watching in despair as vaccines rolled out across parts of world. Need global access for vaccines."
"We are facing a humanitarian disaster. Please do what you can to change this now"
Read 4 tweets
29 Dec 20
Heartbreaking - two reports. mol.im/a/9096257
NHS could face 'horrendous choices' over coronavirus care
theguardian.com/world/2020/dec…
Decisions & actions matter, in summer, Sept,Nov, early Dec. Data is in rear view mirror,hospitalisations,severe illness & tragic deaths lag behind community transmission & cases. Data,messages & messengers questioned/not believed in Sept, decisions delayed, these are consequences
Read 4 tweets
28 Dec 20
Finland detects UK & SA variants. As immune pressure on virus grows, evolution will speed up & any variants that escape that immunity will have selective advantage. Both variants huge worry, variant described SA, may already evade mAbs, variant UK more transmissible
We have to reduce transmission through physical distancing, public health measure, masks, handwashing, behaviour, infection control, plus T-T-I, treatments & vaccines. And these tools available globally.
theguardian.com/world/live/202…
Making Tests,Treatments,Vaccines available globally is a moral imperative. It is a scientific imperative.If not variants that may escape immune control via infection/vaccination that arise in one part world will reverberate everywhere. Truly no one is safe until we are all safe
Read 8 tweets

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