Clinical syndrome rare blood clots temporally associated vaccination but not proven to be causally related must be taken seriously & investigated with an open mind. ft.com/content/45cb34…
Meanwhile follow guidance of independent regulators @MHRAgovuk @EMA_News @WHO who in my view rightly recommend continued vaccine use in all adults
A hypothesis to be tested with studies & data. The rare clinical syndrome temporally related to vaccination is remarkably similar to a clinical syndrome of central venous thrombosis seen after SARS-COV2 infection reported in multiple case reports & series ajnr.org/content/early/…
The Spike protein/RBD in the virus in natural infection & expressed post vaccination leads to a very rare syndrome, mediated thru binding Spike/RBD to endothelium (or possibly clotting cascade) leading to very rare clinical syndrome. Fall in platelets is secondary to the clotting
Hypothesis - the mechanism, the pathogenesis of the rare central venous thrombosis is the same following natural infection & vaccination. The risks being very much greater after infection, hence the benefits hugely in favour of vaccination theguardian.com/world/2021/apr…
Open mind = exploring all possibilities-a shared mechanism leading to a similar clinical syndrome associated with natural infection & vaccination or a different one.But seems odd that such a rare syndrome seen after infection & possibly post vaccine does not have common mechanism
What is common to both natural infection & vaccine? The Spike/RBD not the vaccine vector delivery system.
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