COVID-19 policy blog today cautiously optimistic about turning point near with states who had increased cases/hospitalizations. "In Michigan, testing positivity rates and reproduction numbers are stabilizing or ...falling in many counties"
policylab.chop.edu/blog/covid-19-…
"Our models now forecast declines in reproduction numbers and case incidence over the next four weeks". And importantly for SCHOOLS: "Infections with the B.1.1.7 variant strain grew most quickly for children at the height of the United Kingdom’s winter surge. That, and ..
"rising infections now in youth, has led some to warn the public.. to consider closing schools again in this current resurgence. But our interpretation is far different, and we would advise schools that are doing well to stay the course"..."There is no evidence that the severity
"of infection has dramatically increased in children. .... Overall, rates in children remain much lower than adults and have been falling". Interestingly that is what we concluded from our analysis & was hoping this could be amplified before this:
threadreaderapp.com/thread/1379661…
Very grateful to Policy Lab for concluding same thing regarding schools & children. Here is more analyses from our group using publicly-available datasources:
healthdata.gov/Health/COVID-1… and healthdata.gov/Community/COVI…
MI appears to have hit its peak in hospitalizations as the doubling rate has slowed to 16 days, for 2 days in a row, as of 4/14/21- 16% of all inpatient beds are for COVID-19 (and 80% of all inpatient beds occupied total). 28.1% residents vaccinated, michigan.gov/coronavirus/0,…
This surge coming down so much more steeply (2nd part of curve) than winter because of vaccines-this is exactly but exactly what happened in Israel and then vaccines crushed B117:
news.yahoo.com/us-covid-cases…

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More from @MonicaGandhi9

16 Apr
Pfizer CEO said boosters may be needed. Unlikely
1) T cell immunity from vax (and Abs) work against variants; 2) T cells last long time- 34 y & counting after measles vax; 3) 1st SARS recovered have T cells 17 yr later; 4) Covid Vax generate memory B cells (lymph node biopsy)
So, to back up each claim (I have longer thread on this)
1) T cell immunity from vax works against variants: I hope you have been persuaded
2) T cells last 34 years and counting after measles vaccine:
ncbi.nlm.nih.gov/pmc/articles/P…
3) First SARS pandemic was coronavirus like this one (called SARS-CoV) and it also called severe disease. Lasted 9 months late 2002-2003. Survivors of similar virus SARS have strong T cell immunity 17 years later and counting
nature.com/articles/s4158…
Read 7 tweets
15 Apr
A profoundly important article in my opinion from @davidzweig in my opinion from @NYMag about why children should not be remote learning in the fall. Key points: 1) NJ Governor saying it will not be option unless "world goes sideways"; 2) Remote learning nymag.com/intelligencer/…
harms well documented; 3) "Study after study has shown that schools tend to have lower case rates than the surrounding community"; 4) Dr. "Vincent Racaniello, a professor of microbiology and immunology at Columbia University and author of Principles of Virology, the leading
textbook on the subject, recently concluded, after addressing the mechanisms at work, “I am not worried at all that this virus is going to out-evolve vaccines.'"; 5) Are children at risk? "To put the mortality risk in perspective, the CDC estimates that around 600 children
Read 5 tweets
13 Apr
Rare side effect after J&J vaccine. 6 cases of blood clot called cerebral venous sinus thrombosis (CVST) among women between the ages of 18-48, with symptoms between 6-13 days after vaccination. Out of 6.8 million doses given (0.00009%). U.S. pausing statnews.com/2021/04/13/u-s…
222 cases of CVST out of 34 million people with AztraZeneca vaccine reported as well (0.00006%), most cases in women under 55 years. Of note, both J&J vaccine and AZ vaccine are adenovirus vaccines with DNA coding for spike protein inside them.
sciencemag.org/news/2021/04/h…
Both extremely rare (0.0000006-0.000009) so please first keep that in mind. Postulated mechanism here - syndrome called vaccination immune thrombotic thrombocytopenia (VITT). All patients with low platelets (thrombocytopenia) & unusual clots (thrombosis).
nejm.org/doi/full/10.10…
Read 9 tweets
12 Apr
Sobering article on how there will be a wave of disability & death from other chronic diseases after pandemic (happened in 1918 too). Will be tempting to keep testing asymptomatic after vax, but must turn attention to other health conditions after mass vax
medscape.com/viewarticle/94…
White House reports 88,000 overdose deaths during this pandemic (San Francisco has had 3 times as many overdose deaths than those from COVID-19 during pandemic). Another sobering reality of this painful time.
healio.com/news/primary-c…
And great article about @DrLeanaWen about the epidemic of obesity in US & its increase in the pandemic: "concerning study in which 42% of people self-reported gaining weight since the pandemic began; average addition was 29 lb; 10% reported gaining >50lb"
washingtonpost.com/opinions/2021/…
Read 5 tweets
11 Apr
Good news. Vaccines defanging virus. Public data showing reductions in hospitalizations among those who got vax first (older) very prominent. U.S. Total, Last 7 Days Hospital Admissions, 4/9/21, 37,519 vs. 45,003 2/24/21, -17% (7.5k reduction)
healthdata.gov/Health/COVID-1…
Hospitalizations per case (H/c) ratios:
70+ 4/9/21 9,741 vs. 2/24/21, 17,019: -43% (7.4k reduction)
60-69 4/9/21 7,464 vs. 2/24/21, 9,310: -20% (1.8k reduction)
50-59 4/9/21 7,100 vs. 2/24/21 6,677 or +6% (0.4k increase)
40-49 4/9/21 4,587 vs. 2/24/21 3,975 or +15% (0.6k increase
30-39 4/9/21 3,396 vs. 2/24/21 2,885: +18% (0.5k increase)
18-29 4/9/21 2,363 vs. 2/24/21 2,139:+8% (0.2k increase)
Under 18 4/9/21 843 vs. 2/24/21 1,020: -17% (0.2 reduction)- phew
Unknown, 4/9/21 2,120 vs. 2/24/21 1,919:+10% (0.2 increase)
Read 7 tweets
11 Apr
Another study showing re-infection rare after natural infection. "Establishing whether reinfection is typically symptomatic or asymptomatic, whether reinfected individuals are infectious, and expected duration" of immunity from infection vs vax paramount
thelancet.com/journals/lance…
From awesome SIREN study, which is prospective cohort study in staff working in NHS hospitals across UK (giving us great info about vaccine effectiveness too). Lancet asked for "prior evidence" before this study & re-infection up to Nov 15, 2020 rare - 24 documented infections.
25,661 participants with linked data on antibody and PCR included. If had prior infection (documented by antibodies, T cells not measured), re-infection rare. 1859 new infections: 1704 in the negative cohort & 155 reinfections in the positive cohort. Symptoms among re-infections?
Read 6 tweets

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