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19 Apr, 4 tweets, 2 min read
We've refined a little more our Old Fake estimate as function of Ct values.
Madrid dataset we use included 3 Ct frames, <20, 20-30 & >30.
Our equation changes slightly:

%Old positivity=(Ct-28)/3

It brings a good approximate to calculated Old Detection:

Method used for this refinement was considering all the Ct>20 as true positive and considering Average Ct for >20.

We observe the calculated Old Positivity fits with this average Ct, and we used to estimate the relation.
Our equation also models that every point the Ct Average grows, the Old Positivity increases ~30%, so around Ct~31 and over your detecting almost only Old Fake Positives.
Both cut limit at ~28 and no true detection at ~31 are coherent with the studies on virus viability in culture depending on Ct values.

We see the decline crosses the 50% precisely ~28 and then falls quickly until disappear at ~34.

Not bad for statistics with blurry data.

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More from @plaforscience

plaforscience Profile picture
16 Apr
RELEVANT RESULT

We've found that False (Old) PCR positivity is a function of PCR average Ct.
Fake Old Cases are created if average Ct is over ~27.5
Then on, Fake proportion grows at ~30% for each average Ct point.
At AvCt>31 we will have ~only old fake cases.

The method:
THREAD
We have Madrid dataset with PCR&Antigen test results and PCR Ct averages.

Using them we can calculate the positivities found with each of the methods. We observe they're similar, but PCR is higher with lower prevalence, and Ant with higher prevalence.

Let's compare them.
If we find their proportions we notice PCR is almost all the way giving MUCH HIGHER positivities than Antigen.
They could have same rate (1) if test were technically equal, OR a constant disproportion due to better specificity/sensitivity.
But changing over time makes NO SENSE.
Read 15 tweets
plaforscience Profile picture
15 Apr
Accepting PCR as the Gold Standard because it brings higher positive rates is like choosing a thermometer because it sometimes gives higher temperatures.

PCR/Antigen positivities is NOT constant, varies from ~1/1 to higher than 2/1

That's NOT better detection, but fraudulent +
In our research on Madrid's Ct data (amazing results soon!), we needed the best sensitivity&especificity actual values for PCR&Antigen tests.

It's amazing how studies comparing both ASSUME PCR is the ruler, despite the fact that ELISA results use to align better with antigen's.
When they find low prevalence 2x PCR/Antigen positivities, they never think, hey, it COULD be PCR is detecting too much

Like they didn't know high Ct PCR catches lots of viral non infective fragments

Why could any test get better(or worse) depending on prevalence?!
Read 5 tweets
plaforscience Profile picture
13 Apr
If we check Europe excess death, we see winter seasonal epidemic is done&gone
Current fear bubble&restrictions rush is a Human Artifact politically created thru testing from mid February on
How can it be Armageddon when there's no excess death or even lesser deaths than expected? Image
Of course excess death is NOT the Epidemic, lots of unexpected deaths are occurring due to Covid madness. But they're flat in time, a ~constant background, following the all cause deaths pattern.
The WAVING in excess death will relate the shape of epidemic death, not its height.
The good January correlation death/cases is due to a flat test pressure, as u can see in the most populated countries testing graphics
True trend was detected

Once basal phase was reached, testing pointed slightly upwards, with strong growths in France and TESTING MADNESS in UK ImageImage
Read 4 tweets
plaforscience Profile picture
11 Apr
Apart for the amazing confirmation of the existence of OLD PCR+ noted as cases, we can use the official data on cases detected for test type to do some interesting analysis.

1st wave was obviously a PCR issue, not interesting except for little scale due to lower testing.
Zooming in 2nd&3rd Waves we observe a CLEAR disproportion between them, depending on test type.
2nd wave was over 2/3 of 3rd thru PCR, but less than 1/3 thru antigen!!

The MUST be same proportion. Why is there EXTRA PCR+ positivity?!

We've talked about it LONG AGO:
OLD cases.
That shows even clearer when you draw observed positivity for PCR&Antigen.

3rd wave, the winter seasonal expected wave, shows similar positivities, meaning every kind of test founding the same, but 2nd wave is unbalanced, with only a 60% of positivity thru Antigen.
Read 4 tweets
plaforscience Profile picture
11 Apr
THIS IS VERY IMPORTANT!

We finally get CONFIRMATION that our estimate of Fake Epidemic Creation thru detection of OLD PCR+, non infective, noted as cases, IS CORRECT.

We get access to a new data set, number of + for test technique, that validate our method's values.

Thread:
You can find the model in the link.

We wanted to know the share of PCR+ that were OLD non infectious, using Ct data; and thus finding true Epidemic.

For model development we needed to calculate the number of test that were official positive by type.

The premise is that any test MUST find same TRUE positivity. Then you can develope equations:
PCR+=(True+)+(False+)+(Old+)
ANTIGEN+=(True+)+(False+)

Solving, we get the number of test by type that MODEL PREDICTS must have been officially positive.

Highlighted in foresee graph:
Read 10 tweets
plaforscience Profile picture
4 Apr
We've refined our calculations with Madrid Ct data. We've included pure false positivity, and isolated PCR&Antigen real/official series.

The 2nd wave is showing it's mainly Human made thru test policy, which maintained high proportional levels thru winter: Xmas irresponsibility Image
We can calculate official positive #test for each kind of test, considering Cts

Despite the variable proportion PCR+ are always more important in Epidemic creation, specially weird spikes, not shown in the more natural Antigen+
Guess when is more different?
Yep, Irresponsible! Image
We observed a relation between official positivity and inverted average Ct.

It does mean positivity is contaminated with high test pressure, creating more positivity than real.

We also observe average Ct<28 relates with Epidemic growth, while higher values point descent/plateau Image
Read 5 tweets

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