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CK Eternity

@ck_eternity_

19 Apr

Thinking about the report I found at one point of a tribe in south america that would crush up and snort the tips of their poison darts when their preferred psychoactives weren't available (ayahuasca, etc)

I managed to find the compounds they were ingesting in this case, it turns out the frog secretion commonly used in many poison darts binds to the opioid receptors creating a potent but atypical sedative/analgesic effect, likely potent enough to kill an animal but not a human

It's also possible that the tribe did this semi-frequently and had developed a tolerance to the effects, similar to that seen with the practice of rubbing kambo into skin, another frog secretion which contains similar compounds

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CK Eternity

@ck_eternity_

15 Apr

https://twitter.com/Grimhood/status/1382770816853573635

Postpartum depression seems to stem largely from copper overload disrupting neurotransmitter balance, driven by increased estrogen

Progesterone dropping can contribute as well, as it reduces levels of allopregnanolone, a neurosteroid that potentiates GABA signalling

https://twitter.com/Grimhood/status/1382770816853573635

Allopregnanolone injections are approved for treatment of postpartum with good results, though they can be overly expensive and cause sedative side effects

De-coppering therapies also show good results in some studies, specifically increasing metallothionein expression with zinc

Other nutrients that may increase metallothionein include NAC, manganese, B6, and vitamins C + E, increasing glutathione may also be useful

If free copper is present it's important to be careful not to clear it too quickly, as dumping excess copper can caused many side effects

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CK Eternity

@ck_eternity_

14 Apr

If I could only recommend someone one supplement, it would be magnesium

If I could only recommend two, the second would be thiamine

For magnesium the magnesium chloride and magnesium glycinate forms work best, magnesium taurate is good as well

For thiamine I'd start with thiamine hydrochloride, then upgrade to benfotiamine if you react well to it

The only other nutrient the majority of the population would likely benefit from would be vitamin K2, specifically in the MK-7 form

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CK Eternity

@ck_eternity_

11 Apr

Methylation levels correlate directly with levels of serotonin and dopamine

When methylation is increased, their reuptake back into the neuron is reduced, so both neurotransmitters stay active at their receptors longer, while in undermethylation they are cleared too quickly

This is due to the effect that methylation has on serotonin and dopamine transporters, neurotransmitter production may not change at all, but their activity can be altered

Methylation issues occur in a significant portion of the population and are a huge factor in mental illness

Undermethylation symptoms may include: low pain tolerance, high libido, addictive personality, excess tears/saliva/mucus, elevated histamine, seasonal allergies, addictive personality, perfectionist/OCD tendencies, inner tension, intrusive thoughts/rumination, and calm affect

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CK Eternity

@ck_eternity_

6 Apr

I often get the impression that many people find biochemistry off-putting because the terminology is unfamiliar, but really it's not as complex as it sounds

Here are the definitions of a few terms I commonly use as an example:

Upregulation = an increase in the number of receptors, or production of signalling molecules like hormones or neurotransmitters

Neurogenesis = the creation of new neurons or connections between neurons

Epigenetics = the regulation of how genes are expressed, almost like a bookmarking system that highlights or limits the expression of certain genes

Anabolism = the process of synthesis or building up in biology

Catabolism = the process of metabolism or breaking down in biology

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CK Eternity

@ck_eternity_

5 Apr

Unbound iron in biology triggers a cascade of ROS formation known as a Fenton reaction, which ends in the creation of hydroxyl radicals (some of the most damaging free radicals possible)

This is why the body works to keep iron bound at all times, to protect itself

Iron metabolism is the body relies heavily on copper as an electron donor/acceptor, converting iron back and forth from the soluble ferrous form to the insoluble ferric form

This allows free iron to be absorbed and transported in the ferric form so it doesn't oxidize

Iron is then converted back to the ferrous form to be loaded into different protein structures, for example hemoglobin, where it acts as an oxygen transporter

Retinol is used to synthesize transferrin, which transports and clears free iron

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