Convergent evolution of #SARS_CoV_2 spike mutations, #L452R, #E484Q and #P681R, in the second wave of #COVID_19 in Maharashtra, #India | bioRxiv
#VUI biorxiv.org/content/10.110…
„newly identified lineage B.1.617 possessing common signature mutations D111D, G142D, L452R, E484Q, D614G and P681R, in the spike protein including within the receptor binding domain (RBD)“
„The structural analysis of RBD mutations L452R and E484Q along with P681R in the furin cleavage site, may possibly result in increased ACE2 binding and rate of S1-S2 cleavage resulting in better transmissibility.“
„The same two RBD mutations indicated decreased binding to selected monoclonal antibodies (mAbs) and may affect their neutralization potential.“
#ImmuneEscape
Furin Cleavage Site Is Key to #SARS_CoV_2 Pathogenesis
#PRRAR
pubmed.ncbi.nlm.nih.gov/32869021/

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More from @Marieaaow

28 Apr
@BMG_Bund @jensspahn In der Tat ist das anpassen von mRNA Impfstoff sehr schnell möglich; wobei diese im moment sogar noch das B.1.351 effizient abdecken.
Nun wird in Deutschland aber sehr viel AZ verimpft.
Ein Vektor Impfstoff , schwerfällig in d Anpassung und weit weniger effizient(+Evtl surprise)
@BMG_Bund @jensspahn 👉🏽IMPFSTOFFE SCHÜTZEN VOR INFEKTIONSKRANKHEITEN , indem sie das Immunsystem zur Herstellung von Antikörpern und Vermehrung bestimmter Immunzellen anregen. Sie sind mit die wichtigsten Mittel zur PRÄVENTION gegen Krankheiten.

vfa.de/de/arzneimitte…
@BMG_Bund @jensspahn Also bei “ein bisschen COVID19” hat der Impfstoff nicht das erreicht wofür es steht.
Nach einer Diphtheria Impfung, akzeptiert man auch nicht ein “bisschen” Diphterie 😏
Read 4 tweets

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