Someone asked me yesterday why schools aren't mainly open in San Francisco (despite 30 cases in city of 896K yesterday (& they test), <10 hospitalizations) or California (hundreds of thousand of tests done, 1400 cases in state of 40 million, lowest case rate in nation).
But do think clear why. We took a very partisan approach which - in this case- meant we used a fear-based, exaggerated approach to pandemic management without principles of #harmreduction (harm reduction reduces risk to a pathogen by sensible messages)
nytimes.com/2021/03/18/bri…
And, understandably, if we scared people more and took a fear-based approach, we could hopefully reduce infections by getting people to stay away from each other (a common tactic: people used to use scare tactics with HIV as well) instead of #harmreduction
nytimes.com/2020/12/07/opi…
Scare tactics with HIV says oral sex carries same risk as other types of sex (untrue); #harmreduction would say oral sex safe. Scare tactics with #covid19 says the only way to stay safe is to stay home; #harmreduction says masks, distancing, ventilation work- here's how to apply
So, why parents/teachers still scared of returning to school with such low case rates? Because that was the message for so long (unsafe). Hard to reverse if you start from this position. Those who advocate for school openings (scientists) branded as not being scared of #covid
So by not using #harmreduction, we made people think this virus radioactive, not respiratory virus. This overcaution led to true fear, so that we cannot even think we are safe after vax. People love children; this approach made people think schools unsafe.
theatlantic.com/ideas/archive/…
Please look at links in this article- they are all true facts, links to real data; true epidemiologic facts but still considered controversial that schools should open and scientists that advocate for openings told they aren't fearing #covid enough
usatoday.com/story/opinion/…
And same here- this is declared as a national priority to reopen schools so long ago but schools not open in so many places especially for middle school/ high school. Especially in California.
thehill.com/opinion/health…
And then we thought- okay, cut the Gordian knot. Vaccinate teachers and then K-12 schools can open right away. But fear is very deep for parents/teachers and that fear is very hard to shake.
missionlocal.org/2021/03/oped-i…
Then we saw (especially low-prevalence regions) that false positives with widescale surveillance testing keeping cohorts closed and that testing had not resulted in mitigation of low rates of in-school transmission so we wrote this, but called cavalier
washingtonpost.com/outlook/2021/0…
And then we saw that fear of variants or that children were driving infections in adults were raising fearful narratives that schools could not open or had to close so we looked at publicly-available data to show not true but still fear statnews.com/2021/04/23/use…
So, not sure anything more than the fear-based approach we chose to use (instead of #harmreduction) that kept schools closed (more in West Coast than elsewhere, partisan too); Hope fervently we can change this esp with incredible vax; ok taking 2 day twitter break to work!
And please know that #covid19 is very scary and terrible indeed. It is just that harm reductionists want the same thing as fear-based messengers do: reduce #covid19 infections. But using fact-based messaging on risks, data, #factsnotfear. Okay off twitter to work until Friday.
1 more thing re: fear-based messaging (instead of #harmreduction which aims to achieve same goal of reducing transmission) influencing school closures: when public health officials don't model effectiveness of vaccines (yesterday speech good opportunity to show more could gather)
When officials don't say huge # tests in CA/SF show few cases because vax rates high (70% 1st dose in SF!); when officials still discuss surge when know vax work & only way to get out of pandemic, public confused, think they know something we don't, fear/ school closures continue
When officials say variants can evade immune system w/o data; when officials wear double mask outside after vax which belies science; when officials do not discuss studies on vaccines blocking transmission, school closures post vax will continue. Model vaccine effectiveness
Indeed, SF may be at herd immunity now with 21 cases in city of 896K despite massive testing, 70% 1st dose vax rate, but middle/high schoolers out of school (and limited visitation in hospital). Vax work; this is not due to restrictions; vaccines DO THIS
aamc.org/news-insights/…

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More from @MonicaGandhi9

24 Apr
of passing the virus to others if you are undetectable on antiretroviral therapy because I marveled CDC (a traditionally conservative public health agency, understandably; they are messaging for nation) would put out such a bold statement even though it was true. For breakthrough
infections after vaccination, I hope I, others have convinced you that these are RARE (0.008%) and even more rare for symptomatic infections. 77 million Americans fully vax against COVID, ~5800 symptomatic & asymptomatic but only 4100 symptomatic so 0.005%
cdc.gov/vaccines/covid…
See that nursing homes are still performing asymptomatic testing after vax of staff & residents even though symptomatic swabbing would reveal what we need to know but think this recent MMWR paper important
cdc.gov/mmwr/volumes/7…
Read 10 tweets
24 Apr
Appreciate Healio covering this message with @AmeshAA that our vaccine roll-out messaging should emphasize that vaccines will change your life to decrease vaccine hesitancy (and also appreciate them using the term vaccines are "defanging" the virus):
healio.com/news/infectiou…
Let me show you what is happening in the US which is that ER visits are decreasing for COVID which is sign of defanging but, now, cases are decreasing too (inflection point). 7-day ave
Cases: 4/23/21: 59.9k vs. 70.1k (4/16/21) or -14.6%
4/22/21: 61.8k vs. 70.5k (4/15/21), -12.4%
4/21/21: 63.0k vs. 71.5k (4/14/21) or -11.9%
4/20/21: 64.8k vs. 71.1k (4/13/21) or -8.9%
4/19/21: 67.2k vs. 68.9k (4/12/21) or -2.4%
4/18/21: 67.5k vs. 68.0k (4/11/21) or -0.7%
4/17/21: 68.4k vs. 68.0k (4/10/21) or +0.6%
4/16/21: 70.1k vs. 67.9k (4/9/21) or +3.2%
Read 4 tweets
24 Apr
Wanted to send you 2 articles today that indicate when an epidemic can be downgraded to endemic for an infectious disease. What is an epidemic? An epidemic is when a disease affects a large number of people within a community, population, or region. That is what was happening in
the UK prior to their mass vaccination program. This study in UK looked at 373,402 participants aged ≥16 years who had mass swabbing (even when asymptomatic after vax) Dec 1, 2020-April 3, 2021. In fact, 1,610,562 PCR swabs as vax rolling out.
medrxiv.org/content/10.110…
Whether AztraZeneca (which is like J&J in being an adenovirus/DNA vaccine) or Pfizer (mRNA vaccine), symptomatic infection massively reduced after even 1 dose and importantly so was asymptomatic infection with CT<30 on PCR (at which point extremely hard to transmit).
Read 8 tweets
23 Apr
Two amazing papers recently that show the power of the vaccination to "uncouple" cases from hospitalizations and also massively prevent severe disease. Fully vaccinated Houston, 96% effective at preventing hospitalization; 98.7% at preventing death
medrxiv.org/content/10.110…
Paper, NEJM shows that 2 symptomatic infections (both mild, variants) out of 417 after vaccination (with mass screening program of asymptomatic)-rate of 0.005% consistent with CDC data last week showing 0.005% symptomatic breakthroughs out of 77 million
nejm.org/doi/full/10.10…
The fact that the 2 participants in NEJM study had mild infection with variants is consistent with fact that T cell immunity is preserved across the variants with mRNA vaccination
biorxiv.org/content/10.110…
Read 9 tweets
22 Apr
Thanks Dr. McBride. I think laying out the evidence on why ceasing outdoor masking (except when at rallies or packed crowds) based on biology will help ease us back to normal, shows trust of the public & is nuanced/tiered messaging.
My key points are as follows: 1) People know when they are outside (!); 2) A study in Wuhan China with careful contact tracing shows 1 of 7324 infections seem to be connected with outside transmission (& no outbreaks);
onlinelibrary.wiley.com/doi/10.1111/in…; 2) A meta-analysis from UCSF shows
risk inside >20x more than outside; 3) Scoping review from University of Canterbury shows outdoor transmission rare, citing the opportunity costs of " impact on physical and mental health and wellbeing" not gathering outside.”canterbury.ac.uk/science-engine…
Read 4 tweets
21 Apr
Want to talk about INFLECTION POINT and how it looks like we have reached this in our country with hospitalizations at this vaccination rate & also turning the corner in Michigan. We discussed this first with Israel & I think "inflection point" with both hospitalizations & cases
will be different by country/state/region depending on degree of natural immunity there. This article in Nature from early on in the Israel roll-out: "You need to vaccinate much >1/3 of the population to really see a reduction in transmission", how much
nature.com/articles/d4158…
more probably depends on 1) natural immunity (surges before (CA has 38% of its population exposed); 2) degree of lockdown as you are vaccinating (UK more; Israel less; places in US variable); 3) maybe even what vaccine (?India). Paper from Israel (Fig)
nature.com/articles/s4157…
Read 15 tweets

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