Methyl-B12, betaine, and SAMe all increase methylation by providing methyl groups for reactions, with methyl-B12 being the least potent, and SAMe being the most
Niacin decreases methylation by depleting methyl groups from the liver during metabolism, and increases acetylation
Niacin decreases methylation by depleting methyl groups from the liver during metabolism, and increases acetylation
Folate is especially interesting as it dynamically regulates methylation, acting as a cofactor for methylation reactions in normal concentrations, while decreasing methylation downstream of its activity at the folate receptor when taken at higher doses
B6 is required to clear methyl waste, aka homocysteine, allowing it to be metabolized into useful cysteine, sulfate, and taurine
B2 is a cofactor for the metabolism synthetic folic/folinic acid from plant foods and supplements
B2 is a cofactor for the metabolism synthetic folic/folinic acid from plant foods and supplements
Many people automatically assume they should take SAMe to increase methylation, but in many cases this can be harmful as it spikes homocysteine production
Sufficient concentration of B6, B12, and folate must be established to clear/recycle homocysteine and keep the cycle flowing
Sufficient concentration of B6, B12, and folate must be established to clear/recycle homocysteine and keep the cycle flowing
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