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Dr Zoë Hyde

@DrZoeHyde

6 May

Here’s a very good news story. New studies show the Pfizer-BNT vaccine works incredibly well, including against the South African variant (the most immune-evading variant known).

But the second dose is critical.

The Novavax vaccine also holds up well against the SA variant. 🧵

Real-world data from Qatar show the Pfizer-BNT vaccine is effective against the UK and South African variants, but only after the second dose.

For example the vaccine was only 39% effective against severe disease after one dose, but this rose to 97% (92-99%) after two doses.

Here’s the effectiveness by first, then second dose:

Infection:
🇬🇧 29%, 89%
🇿🇦 17%, 75%

Severe disease:
🇬🇧 54%, 100% (82-100%)
🇿🇦 0%, 100% (74-100%)
Any variant: 39%, 97% (92-99%)
nejm.org/doi/full/10.10…

Read 10 tweets

Dr Zoë Hyde

@DrZoeHyde

1 May

A security guard at the Pan Pacific hotel in #Perth has tested positive, along with two housemates. Short thread with the details.

If you’ve visited any of these sites, you must get tested & quarantine until you receive a negative result.

Masks are mandatory when leaving home.

A hotel quarantine security guard who received their first dose of the Pfizer-BNT vaccine about 1 week ago, worked at the Pan Pacific hotel on the 24th, 25th, and 26th of April.

On the 24th, two international arrivals who would later test positive arrived at the hotel.

The arrivals were from Indonesia and the US. One was infected with a variant common in the US.

The security guard, who developed symptoms on the 29th, is believed to have become infectious on the 27th. He tested positive yesterday, on the 30th of April.

Read 6 tweets

Dr Zoë Hyde

@DrZoeHyde

29 Apr

A good news study of long COVID in 151 Australian children who tested positive for SARS-CoV-2.

12 (8%) had persistent symptoms lasting up to 8 weeks. Cough and fatigue were the most common symptoms.

However, all eventually recovered.
thelancet.com/journals/lanch…

A possible limitation is that mostly young children were studied.

Over half were aged <6 years, and 8 of the 12 children (67%) with long COVID were aged <3 years. As such, it may not be representative of all children.

Other studies have reported a longer duration of symptoms.

https://twitter.com/drzoehyde/status/1377585071595511811?s=21

However, the proportion of children with long COVID in this study (8%) is consistent with data reported by the Office for National Statistics in the UK.

In the ONS data, 7-8% of children and adolescents reported symptoms lasting at least 12 weeks.

https://twitter.com/drzoehyde/status/1377585071595511811?s=21

Read 4 tweets

Dr Zoë Hyde

@DrZoeHyde

22 Apr

@liammannix

This article contains a number of inaccuracies, @liammannix. The results of the REACT-1 study in England (and many others) are indisputable: children are frequently infected with SARS-CoV-2.

Anyone who says otherwise at this point is either ignorant, or has an agenda.

https://twitter.com/liammannix/status/1384660965346533386

https://twitter.com/drzoehyde/status/1367458017134833665?s=21

Furthermore, there is now solid evidence that children transmit the virus at quite similar rates to adults.

At one point in England, children were more likely to bring the virus home than adults, and were more likely to infect their family members.

https://twitter.com/drzoehyde/status/1367458017134833665?s=21

https://twitter.com/drzoehyde/status/1352646048720670720?s=21

It’s mathematically impossible to achieve herd immunity without vaccinating children and adolescents.

Children also need to be vaccinated for their own sake. It’s been described as both an “ethical obligation and a practical necessity.”

https://twitter.com/drzoehyde/status/1352646048720670720?s=21

Read 4 tweets

Dr Zoë Hyde

@DrZoeHyde

12 Apr

Study of 25,661 UK healthcare workers (including 8,278 with past COVID-19), showing past infection offers 84% protection against reinfection (93% for symptomatic disease) over 1-7 months. The emergence of the UK variant didn’t make reinfection more likely.
thelancet.com/journals/lance…

During the study, participants had a PCR test every 2 weeks, and an antibody test every 4 weeks, so we can be reasonably sure the majority of cases would have been detected.

There were 1,704 infections in people who hadn’t previously had COVID-19 (of which 17% were asymptomatic), and 2 probable and 153 possible reinfections (1.9%), of which 49% were asymptomatic.

Read 7 tweets

Dr Zoë Hyde

@DrZoeHyde

11 Apr

Study of the Pfizer-BNT vaccine in 100 nursing home residents (64 with past COVID-19) & 15 healthcare workers.

A good antibody response was detected in 97% with past COVID-19, 93% of healthcare workers, but only 61% of residents who’d never been infected.
academic.oup.com/cid/advance-ar…

A similar pattern was found with regard to cellular immunity.

A good response was found in 97% of residents with past COVID-19, and in 87% of healthcare workers, but only 48% of residents who’d never been infected.

This study was done 4 weeks after the first vaccine dose.

It’s unclear if the results indicate that older people may take longer to have a good response to the vaccine, or if it is less effective in older people.

If the latter, attaining herd immunity becomes more important.

Read 5 tweets

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