They've registered Sputnik Light in Russia, again on very thin data, again not waiting for phase 3. It's not a new vaccine: it's the 1st half of Sputnik V - an adenovirus 26 shot. Given the production problems since early on with the other half (Ad5)...1/n sputnikvaccine.com/newsroom/press…
...it's not surprising. (The Ad5 shot is the one there was a lot of controversy about recently because of replication-competence.) So it becomes a single-shot adenovirus vax (like J&J's & CanSino's) & it's half the price: full Sputnik V was expensive for Covid vax...2/n
...The data basis? 3 things: Immunogenicity results of a phase 1/2 trial with 110 people - some outcomes summarized in the press release only. Here's the trial register entry for it...3/n clinicaltrials.gov/ct2/show/NCT04…
...2nd: a claim of efficacy of 79.4% based on a group of people who failed to get the 2nd shot in Russia's vaccination program. They've made claims on the basis of this data before - it's linking a register of vaccinations with a register of people diagnosed with Covid-19..4/n
...Less than 3% of the whole population has had Sputnik V, according to a previous press release, & the proportion of those that didn't get the 2nd shot are obviously highly likely to have major differences to the rest of the population ...5/n
...Nevertheless, that's the basis of the claim of efficacy: the rate of infection shown for people who aren't vaccinated at all in the whole of Russia vs the rate of infection of people who didn't get the second Sputnik V shot...6/n
...And a 3rd claim: "Sputnik Light has proven effective against all new strains of coronavirus, as demonstrated by the Gamaleya Center during laboratory tests." As far as I know, none of this is public. Whereas here's a preprint ...7/n
...that found 8/12 serum samples from people vaxed with Sputnik V had signs indicating failure to neutralize B.1.351 ("SA" varian), etc medrxiv.org/content/10.110… ...8/n
...Press release states 20 million doses of Ad26 used globally with no cases of Cerebral Venous Sinus Thrombosis (CVST) reported. Given it occurs even without vax, lack of reporting can't be taken as evidence of absence.
Can't think of anything diplomatic to say about this.
9/9
Can't think of anything diplomatic to say about this.
9/9
PS: My sources on that data linkage issue & full Sputnik V having been taken used by <3% of the Russian population: sputnikvaccine.com/newsroom/press… 3.8 million, population of Russia: 146.7 million en.wikipedia.org/wiki/Demograph…
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