Thread by @spy_sci

Now as everyone is talking about #2DG that is made by @DRDO_India, some people are also claiming that the hypothesis was first put forward by #Patanjali. Here is my take on the paper by #Patanjali (1/6)

@Neurophysik @GorwayGlobal @drabbyphilips @ForBetterSci

In this work, #2DG is docked with key viral proteins such as viral spike glycoprotein S2, viral NSP15 endoribonuclease, and protease 3CLpro. Other in-silico parameters like drug likeliness, bioactivity indices, and ADMETox have also been studied to generate supportive data. (2/6)

First of all, this is an in-silico paper and not an in-vitro paper or a RCT. That itself means that everything written in it is plain speculation. Secondly, the paper is still on a #Preprint server @authorea which means that it has not been peer-reviewed. (3/6)

It is well known that molecules like #2DG are metabolic modulators. It's funny to imagine that a metabolic modulator has been proposed as an inhibitor that will physically bind to the viral proteins and inhibit their actions.🤭(4/6)

Now going with the same logic, instead of #2DG, if I just dock Glucose or Fructose with these viral proteins, then what is the proof that I am going to get docking scores that are any different than those of #2DG. The logic of this study itself is completely wrong. (5/6)

Tons of researchers have also published similar #Docking studies with natural or FDA-approved drugs. This is nothing but #Covid opportunism clubbed with poor scientific practices. Such studies can only ⬆️ H-index but will not contribute towards scientific knowledge. (6/6)