The bat morbillivirus paper is finally out! I'm so proud of this work and grateful for all of the scientists involved in this tour de force of virology. A particularly huge shoutout to @satoshi84570237 for spearheading this project. 1/
Of note, we extensively characterized MBaMV in regards to potential for zoonotic crossover. In brief, human sera that is reactive to the MMR vaccine also neutralizes MBaMV (whew) and MBaMV does not antagonize human interferon. 3/
Since anti-vaxxers seem to care so much about “naturally acquired immunity,” perhaps we should tell them that if they get Measles, their immune system will be depleted and much of that “infection-earned” memory could be lost and potentially reduce COVID antibodies. 1/n
One reason this “immunological amnesia” occurs is because Measles is really good at infecting multiple immune cell types. Which you can guess are important for preserving immune memory and antibody levels. 2/ science.sciencemag.org/content/366/64…
Infection with Measles causes life-long immunity, but at the cost of immune memory to other pathogens. Fortunately, the live-attenuated vaccine for Measles is incredibly effective at preventing infection AND, in doing so, helps preserve your immune response to other pathogens. 3/
In honor of it being the last day of June—which is CMV awareness month—let’s do a thread!
Human Cytomegalovirus, or HCMV, is a human herpesvirus related to HSV (herpes), VZV (chickenpox), and EBV (causes mono). But HCMV doesn’t get enough attention. #stopCMV 1/15
HCMV is ubiquitous, which is science jargon for common. By mid-adulthood, most people are infected with HCMV. Seroprevalence (the amount of people with HCMV-specific antibodies) is more than 85% worldwide. You probably have HCMV. 2/ pubmed.ncbi.nlm.nih.gov/30706584/
Because HCMV is a herpesvirus, once you are infected, you are infected for life. This virus is suuuuuuuper sneaky and can hide out in various cells in your body forever. We can’t cure it right now (or any herpesvirus for that matter). 3/
After perusing social media and talking with my non-scientist friends, the biggest concern I keep hearing about COVID vaccines is that the speed at which they’re being developed makes people question the vaccines’ safety. 1/
There will ALWAYS be people who are anti-vaxx, no matter what. No amount of evidence, personal conversation, empathy etc. will change their minds. I can usually spot these people quite fast and have learned not to engage further. It’s futile and draining. 2/
But there are a lot more people who are ‘vaccine hesitant.’ This definitely applies to how people view COVID vaccines. Even friends of mine I’d consider science literate are wary of how fast the vaccine process is moving. 3/
To bring some levity to the craziness that‘s been this week in #coronavirus news, here’s a thread of how I’m processing it all with Harry Potter gifs. 1/
How it felt sitting together after Monday meeting in the Microbiology department at Sinai, discussing the latest science and medicine regarding #SARSCoV2 2/
Me, when I see a tweet by the president indicating he cares more about the stock market and his image than human lives and preventing a pandemic. 3/
When I started grad school, I was certain I wanted to join a virology lab, so 3/4 of my rotations were in molecular virology labs. I was having fun, but was overwhelmed with classes and imposter syndrome. 2/n
Halfway through my last rotation, I found myself staring in disbelief at a positive pregnancy test. (Sidebar: Birth control is only 99% effective when taken correctly, y’all) This was 8 months into a PhD program and I was terrified. 3/n