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Mac n’ Chise 🧬🦠🧫 Profile picture
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15 May, 5 tweets, 2 min read
Extremely welcome news today! A new study from the Indraprastha Apollo Hospital in Delhi, India shows 97.38% of a total of 3,235 HCWs vaccinated with Covishield (AstraZeneca) were protected from COVID-19 infection and the chances of hospitalization after vaccination were 0.06%.
The study was designed to evaluate the frequency of breakthrough infections, and was carried out on healthcare workers who reported to Delhi's Indraprastha Apollo Hospital with symptomatic COVID-19, during the first 100 days of the vaccination drive using the Covishield vaccine.
The results of the study show that break-through infections occur only in a small percentage and these are primarily minor infections that do not lead to severe disease. There were no ICU admissions or deaths reported!
While we wait on the study preprint: hindustantimes.com/lifestyle/heal…
Vaccinations of HCW began on January 16th and based on the article cutoff point was 100 days after so that brings us to around April 26th, this is what the spread looks like (note B.1.617.2)! Thank you @Castdeath97 for linking me to this! (Graphic is from @TWenseleers)

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Mac n’ Chise 🧬🦠🧫 Profile picture
12 May
A recent study shows that a single dose of AstraZeneca’s vaccine in HCWs previously infected with SARS-CoV-2 serves as an effective immune booster up to at least 11 months post infection and effectively neutralizes WT, and SARS-CoV-2 variants of concern P.1, B.1.1.7, AND B.1.351!
Researchers here compared spike-specific IgG and pseudo-neutralizing spike-ACE2 blocking antibodies against SARS-CoV-2 wild type and variants B.1.1.7, B.1.351, and P.1 following two doses of Pfizer’s vaccine and a single dose of AstraZeneca’s vaccine in 232 healthcare workers
with and without a previous SARS-CoV-2 infection. What they found were that post-vaccine levels of spike-specific IgG AND neutralizing antibodies against the SARS-CoV-2 wild type and all three variants of concern were similar OR indeed higher in participants receiving a single
Read 5 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
11 May
Everyone needs to read this today. Yes, the vaccines ARE working. India is using Covishield (AstraZeneca/SII) and Covaxin. India’s rise in infections appears to be leveling off today via Our World in Data.
The issue is not the vaccines themselves. It’s supply and distribution against a variant that is heavily circulating through a majorly unvaccinated population. Anyone telling you otherwise isn’t bothering to read.
Let’s clear up some confusion on the study on neutralization of variant B.1.617.1 first identified in India (not B.1.617.2 which is the designated variant of concern in the UK) live virus by post-vaccine sera with Moderna/Pfizer. Yes, ALL vaccine sera neutralized the virus.
Read 5 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
10 May
Immunological memory wins! A recent study shows immunity in convalescent individuals will be VERY long lasting and that convalescent individuals who received an mRNA vaccine produced antibodies and memory B-cells that will be protective against circulating SARS-CoV-2 variants!
Here, researchers reported on a cohort of 63 COVID-19-convalescent individuals assessed at 1.3, 6.2 and 12 months after infection, 41% of whom received an mRNA vaccine. In the absence of vaccination, antibody reactivity to the receptor binding domain (RBD) of SARS-CoV-2,
neutralizing activity, and the number of RBD-specific memory B-cells remained relatively stable from 6 to 12 months. However, vaccination increased ALL components of the humoral response, and as expected, results in serum neutralizing activities against variants of concern that
Read 9 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
1 May
Good news all around this morning! Preliminary data shows the vaccines are indeed effective against B.1.617, the variant first identified in India. In addition, the vaccines utilized in Brazil (Coronavac and AstraZeneca) are indeed working and prove to be effective against P.1!
Per the Gupta lab, this gives us good reason to believe vaccination in India will contribute to control of transmission as well as the severe effects of COVID-19. Preprint is not available yet but the thread is encouraging. When the study is up I’ll gladly share it.
Now for Brazil and P.1. As 1st doses were administered to over 95% of 80+ year-olds reaching 49.1% in weeks 5-6 and over 90% after week 9 of the study. (77% CoronaVac, AZ 16%), COVID mortality rate began to decline rapidly DESPITE P.1. being dominate.
Read 5 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
29 Apr
Once a country with the world’s highest COVID rate, Gibraltar is now an almost fully vaccinated country (85% of adults vaccinated) who has not seen a case since late March. This is what life is like now in a fully vaccinated country.
slate.com/news-and-polit…
“After two months of more or less unrestricted life, one thing is clear: Vaccines do work. There have been no active cases among Gibraltarian residents for three weeks now.” Image
Per the article, “COVID ward of St. Bernard’s Hospital has seen two hospitalizations and zero deaths since March 14. If anyone still needs convincing that vaccination is worth it, they won’t find a better case study than “Gib.”
Read 4 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
28 Apr
Wonderful news this morning! A study out of PHE shows 38-49% relative reduction in transmission in breakthrough cases after just ONE dose of Pfizer or AstraZeneca’s vaccine. This, on top of infection effectiveness, gives 75-82% effective transmission reduction from just ONE dose!
And here is the paper! Thank you for the heads up @fact_covid!
khub.net/documents/1359…
To put it another way: those who received their 1st dose of either Pfizer's or AstraZeneca’s vaccine and who became infected 3 weeks later were between 38% and 49% LESS likely to pass the virus on than unvaccinated individuals, this being on top of a reduction of at least 60-65%
Read 4 tweets

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