Thread by @VietHeartPA

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Join us now - Prevention and Health Promotion and the year in review. Dr. Donna Polk presenting.

acc21.virtual-acc.org/topic-essentia…

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The "Covid 19" weight gain?

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Yes, the "covid 19" weight gain did occur. How do we combat it though? why did it occur?

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Covid restrictions to reduce cases via large group gatherings impacted our usual #exercise routines.

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Like any disruptive event, covid impacted/accelerated other parts of healthcare. #cardiacrehab #telehealth @iamritu

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What changed in lipid therapy, more specifically, our knowledge in statin use in 2020? #Statinwise #Sampson - Those with statin myalgias, can be reinitiated on statins long-term. #Nocebo like statin myalgias, is just as real.

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We know weight loss can be difficult, it carries many many stigmas, and also can contribute to amplification of other chronic disease states. Semaglutide was shown to help reduce weight. #GLP1Ra

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Intensive BP management to <120 vs <140, how did this impact cognition and dementia development?
- No difference in probable dementia.
But,
- Mild cog impairment and mild cog+probable dementia did have protection.

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Dr. Polk summarizes that the lessons learned and provides opportunities for us to improve on prevention.

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Next up Dr. @mchonig - CV and Renal outcomes across glycemic spectrum.

acc21.virtual-acc.org/topic-essentia…

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1st, remember that there is a well-established association of CVD and Renal disease with Type 2 DM.

What is the risk of cardiorenal outcomes though across the glycemic continuum/spectrum (beyond T2DM)?

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Great visuals and tables on the HR for incident outcomes . N=46,911 and 14% developed incident T2DM.

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For the full results, characteristics, please watch Dr. @mchonig full presentation. Below are the summary and implications.

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Are there sex differences in genetic risk for HTN?
Dr. Aittokallio up now.
acc21.virtual-acc.org/topic-essentia…
Thoughts? @AnastasiaSMihai @jbrianbyrd @Hragy @hswapnil @DrMarthaGulati

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Finland population. Polygenic risk scores for blood pressure.

@skathire @pnatarajanmd

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Results and Conclusions.

PRS may help communicate risk to our patients, prioritize pharmacotherapy vs lifestyle interventions alone.

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Next up @DrKene. Don't miss this very interesting evaluation of Alcohol on CVD! Is ETOH protective or Harmful?

I will try to come back to this as my talk is next.

acc21.virtual-acc.org/topic-essentia…

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History of EtOH use. It's been used throughout our human history. A J-shaped curve - a little is good, but a lot....

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Love the approach and hypothesis here. Is the benefit of EtOH mediated by its anxiolytic properties?

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Methods. MGH Biobank, surveys, and ICD mining

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Methods, continued. ICD Dx mined and imaging

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Results - Moderate alcohol associated with lower MACE, lower stress.

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As noted in previous post, moderate EtOH associated with lower MACE and lower stress associated neural activity. This provides nuance on why/how EtOH associates with decrease MACE.

Important question - can we parse weekend drinkers vs daily drinkers in this data?

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Next up: Dr. @paragchevli - Metabolomics in atherosclerosis from the diabetes heart study.

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Well, you heard the sub-study results of #STRENGTHtrial. We hope to provide nuance to the Omega 3 CVOT trials. Recognizing that there appears to be a difference from EPA-only vs EPA/DHA mixed preparation trials.

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Lots of controversy in OM3. We looked at circulating serum levels of EPA and DHA, unadjusted/adjusted for one another and adjusted for comorbidities.

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A reminder of the EPA and DHA doses in contemporary CVOT in OM3 and outcomes.

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N = 987 from the INSPIRE Registry. All undergoing coronary angiography.

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Results - 1

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Results - 2

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Happening now - our @intermountain data on EPA and DHA impacts on one another and MACE.
acc21.virtual-acc.org/topic-essentia…

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Dr. Audry Chacin-Suarez up next!
acc21.virtual-acc.org/topic-essentia…

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Does an increase in peak Vo2 in #CardiacRehab associate with lower MACE?

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Great presentation by @audrychacin
#CardiacRehab resulting in an increase in peak %Vo2 from pre to post rehab resulted in a decrease in MACE. Not surprising, those with the greatest change had the greatest reduction in risk.

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My apologies, here is the conclusion slide. @audrychacin