#aha22 - SPORT trial

💊nutraceuticals ubiquitous and “assumed” by many pts to be heart healthy.
💊💰💸industry
💊 SPORT ➡️ compared to rosuva and placebo, do they impact biomarkers?
jacc.org/doi/abs/10.101…
@kewatson @ErinMichos @ljlaffin 1/ N=199, randomized single blind
💊 lipid, hsCRP, CMP. Baseline and at 28 days.
💊 1° risk, age 40-75, LDL-C 70-189, borderline to upper intermediate risk (5-20%, estimated 10 yr event)
💊 1° endpt: %LDL-C change vs rosuva
💊2° endpt: biomarkers vs rosuva; vs placebo
#aha22 2/

@mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape EPA effect on ASCVD in Japanese pts w/chronic CAD and EPA/AA ratios <0.4, on statins.

🐟EPA 1.8 gm (like JELIS)
🐟EPA baseline 46 ug/mL (JELIS, 96)
🐟All on statins, randomized to control or EPA, no blinding (like JELIS)

#aha22 1/ @AHAScience @mmillermd1 @PennCardiology @DLBHATTMD @UM_Cardiology @ASPCardio @nationallipid @BudoffMd @Medscape @AHAScience N=2506

🐟interesting drop out rate/protocol deviation, covid era?
🐟LDL-C baseline, similar to reduce it
🐟EPA median 46 ug/mL, higher than reduce it (26), lower than Jelis (96).
🐟hsCRP ~0.40
2/ #aha22

Dr @DrCaliff_FDA providing the opportunities we have to improve health in the US #AHA22 #AHA22 What the @US_FDA hopes and seeks to do

I have never claimed to be fashionable and rarely do I ever match ☺️

I am wearing my heart shoes and my red dress tie from @HeartNews @AHAScience @GoRedForWomen

#AHA22 Day 1 My shoe buddy and frankly the genesis for why I purchased these shoes @KnightSNPs

Stop by S3156. Dr Knights poster on #disparities in #research. #aha22

We need to fix it.

TRANSFORM-HF

What do we really know about efficacy of furosemide vs torsemide?

I am sure @robmentz and team have something to say about this 👊🏾

pubmed.ncbi.nlm.nih.gov/33714745/

#AHA #LBCT @AHAScience @noshreza Chlorthalidone versus HCTZ - pragmatic emr study by @Areefishani et al. After #SPRINTTrial I use chlorthalidone. What’s the evidence?

pubmed.ncbi.nlm.nih.gov/35390512/

#AHA #LBCT @AHAScience @noshreza

#ACC21

Join us now - Prevention and Health Promotion and the year in review. Dr. Donna Polk presenting.

acc21.virtual-acc.org/topic-essentia… #ACC21

The "Covid 19" weight gain?

#ACC21

Ensuring diversity - acc21.virtual-acc.org/engage-channel/

Come listen to these wonderful talks in how we strengthen diversity - #ACC21

I love the advice to have cross professional recruiting, e.g. include other #ACCCVT in recruiting physicians and vice-versa.

#ACC21

Nice work #STRENGTHTrial team! #OM3

First - primary endpoints not achieved. This is a sub-study.

Questions attempted to address:
- Could higher EPA explain favorable outcomes?

- Could DHA component have exactly counterbalanced benefits of EPA?

1/ #ACC21
Recall #STRENGTHtrial randomized 13,000+. Similar MACE outcomes to #REDUCEIT.

STRENGTH sub-study looks at top tertile achieved EPA and DHA compared to corn oil.'
2/

#CVLipids #CardioTwitter #PriorAuthDenial

A thread for education, dissipation of annoyance, and showcase for silliness of insurance prior authorization. @UHC @askUHC @UHC_EH @myUHC 1/ #PCSK9i
1.Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL Receptor (LDLR)
2.LDLR, protein that brings LDL into the liver cell to be broken down
3.PCSK9=overmanaging boss who fires you despite a job well done
#CVLipids #CardioTwitter #PriorAuthDenial 2/

#covid19 restrictions on visitors to the hospital. Met with pts family outside to get hearing aids to their hospitalized family member. Text: “I’m the bald asian guy in a white coat and mask 😉”. 😂😂😂 Sent this pic so they knew what I looked like. #intmtnapp #PAsCanDoThat … My plea: Be intentional about care of the patient. While the illness may be why they are in clinic/hospital, it is the human we are caring for. I feel weird that it is “more care” to obtain hearing aids and set up communication (also offered to take ipad in to pt). 1/