Aaysha Cader Profile picture
May 17, 2021 16 tweets 22 min read Read on X
#ACC21 late-breakers🧵
1/Antiplatelets: Let's start with #aspirin
❌ADAPTABLE :Aspirin 325 mg vs 81 mg in ASCVD pts
No difference in death/ MI/ stroke/major bleeding
💎pragmatic trial: EHR-identified pts
💎significant dose switching in 325 mg group
nejm.org/doi/full/10.10…
✅Host Exam: Aspirin vs Clopidogrel in chronic Maintenance monotherapy after #PCI w/ DES
#Clopidogrel monotherapy reduced composite of death, non-fatal MI, stroke, ACS re-admission, BARC >=3 bleeding, compared to #aspirin monotherapy.
❓East Asian paradox
thelancet.com/journals/lance…
✅TALOS- AMI: De-escalation ✅
In pts w/ no major events in 1st month after index PCI, de-escalation of DAPT from #ticagrelor to #clopidogrel is superior to tica-only DAPT in terms of net clinical benefit, with
⬇️decreased bleeding 🩸risk
- no increase in ischaemic risk
#ACC21
4/ Now onto NOACs
ATLANTIS❌
Full-dose #apixaban is NOT superior to SOC antithrombotic treatment among patients undergoing #TAVI despite a reduction in valve leaflet thrombosis.
💎safety (bleeding) of apixaban is similar to that of current SOC
#ACC21 @mirvatalasnag @ShrillaB
5/VOYAGER-PAD
#Rivaroxaban 2.5 mg bd with aspirin vs aspirin alone reduces first & subsequent adverse limb & cardiovascular events in patients with #PAD undergoing lower extremity revascularization.

@JACCJournals publication: bit.ly/33QBsRr

#ACC21 @taraloujones
6/ 🥀#FLOWERMI
❌FFR-guided PCI of non-IRA did not reduce composite outcome of death, MI or urgent revasc at 1 year, compared with angio-guided PCI in STEMI patients with MVD

@nejm simpub:
nejm.org/doi/full/10.10…

#ACC21 @ACCinTouch @ncurzen @SukhNijjer @tabaza @Julio_Farjat
7/ Negative trial for #ARNI
PARADISE-MI
❌Compared with ramipril, #sacubitril/valsartan did not reduce the primary endpoint of CV death, HF hospitalization or outpatient HF requiring Rx in a contemporary enriched acute MI population (EF≤40%).

acc.org/latest-in-card…

#ACC21
8/ Also #ARNi❌LIFE
Compared to Valsartan only, Sacubitril/valsartan did NOT⬇️NT-proBNP or clinical composite of no of days alive,out of hospital & free from HF events, in patients with advanced HFrEF & comorbidities

💊sicker pts, lower BP, worse renal function, ⬇️ LVEF, ⬆️AF
9/ Win for #soitagliflozin
✅SOLOIST-WHF and SCORED 

Pooled data showed benefit of sotagliflozin in reducing composite of total CV deaths, HF hospitalizations, & urgent HF visits in pts with both diabetes& HF
🌟across full range of EF, including HFpEF
🌟men &women

@DLBHATTMD
10/ negative #COVID-19 trials
❌INSPIRATION-S: atorvastatin 20mg/d failed to reduce venous or arterial thrombosis, Rx with ECMO, or all cause mortality in #COVID19 ICU pts

@bbikdeli @HeartOTXHeartMD @Umair2017 @VietHeartPA @torresviera @CardioNerds @cardiojaydoc02 @rahatheart1
11/
❌DARE-19
#dapagliflozin failed to reduce organ dysfunction or death, or improve recovery, compared with placebo among in noncritically ill hospitalized #COVID19 pts

#ACC21 @ACCinTouch @Sarah_Moharem @sarahhudsonuk @HeartOTXHeartMD @hvanspall @chiarabd @sabeedak1 @JGrapsa
12/
❌Coalition ACTION
In hospitalized #COVID19 pts w/⬆️D dimer levels, initial in-hospital therapeutic AC did NOT improve clinical outcomes& increased bleeding compared w/prophylactic AC
-stable pts: #rivaroxaban 20 mg OD
-unstable pts: enoxaparin, then rivaroxaban to 30 days
13/ #LAAOS-lll✅
On a background of anticoagulation, surgical left atrial appendage occlusion during cardiac surgery reduced ischaemic stroke in pts with AF

nejm.org/doi/full/10.10…

#ACC21 #EPeeps @m_tahakhan @KTamirisaMD @HafizaKMD @A_FelixOliveira @ovidiogarciav @pomyers
14/ ✅RADIANCE-HTN TRIO
-In hypertensive pts resistant to triple combination therapy, ultrasound #RDN showed 8mmHg ⬇️in daytime ambulatory SBP vs sham
-BP⬇️effect of RDN vs sham consistent for 24h,
nighttime &office SBP

@ACCinTouch @ajaykirtane @drandrewsharp @ShrillaB
15/ CAPITAL-CHILL🥶
❌Moderate hypothermia NOT superior to mild hypothermia in improving mortality or neurological outcomes at 6 months among comatose patients with out-of-hospital cardiac arrest

#ACC21 @ACCinTouch @DeepDastidar @DrAsifQasim @DrKeeble @AnnaKateBarton @avolgman

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Aaysha Cader

Aaysha Cader Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @aayshacader

Dec 4, 2021
Such an important topic!Sex-related eligibility criteria leading to exclusion of women from clinical trials. @hvanspall proposes pragmatic eligibility criteria facilitating enrolment of women &URM in RCTs
#CVCT2021 @CVCTForum @SantosGallegoMD @DrRaniKhatib @drdargaray
@FaiezZANNAD on geographic equity in CV clinical trials:increasing research capacity & trial enrolment in LMIC Case in point:MENA region
#CVCT2021 @CVCTForum @docbhardwaj @DjawidHashemi @DrRaniKhatib @hvanspall @DrRajivsankar @drdargaray @DVervoort94 @mirvatalasnag @Hragy
Read 17 tweets
Dec 4, 2021
Some great insights on limitations of perioperative antiplatelet Rx & limitations of guidelines - the issue perioperative antiplatelet and HBR are not the same! #CVCT2021 @CVCTForum @docbhardwaj @SantosGallegoMD @AHajduczok @DrRaniKhatib @DrRajivsankar @FaiezZANNAD @DLBHATTMD
Read 7 tweets
Dec 2, 2021
Dr Joseph Hill @CircAHA on the nuances and challenges with publishing artificial intelligence analyses of trial databases:
#CVCT2021 @hvanspall @rachkataria @SantosGallegoMD @AlexNowbar @DrRajivsankar @cristina_gavina @A_FelixOliveira @BoldiKovacsMD @docbhardwaj @drdargaray ImageImageImage
@cardiobrief Larry Husten raises an important issue; should trials be released to the press before full publication is available?
#CVCT2021 @hvanspall @rachkataria @SantosGallegoMD @AlexNowbar @CVCTForum @drdargaray @DrRajivsankar @DrRaniKhatib @AHajduczok
Read 5 tweets
Aug 30, 2021
#ESCCongress When coronary angiography is not enough: @RaberLorenz turns on the light with #OCT
🔦ACS-⬆️resolution of OCT -gold standard to ID thrombus, ID unclear culprit, ACS aetiology, rule-in & rule-out
🔦#MINOCA
🔦Stent thombosis
🔦Optimize PCI
@mirvatalasnag @Hragy
Read 6 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(