Thread by @BillyBostickson

1. SARS-CoV-2 variants arise during individual infections
virology.ws/2021/04/22/sar…
A study of variation at the genome level indicates that diversity in a single host has been underestimated.

2. This is the story of what the doctors witnessed, over the course of his illness: the evolution of covid-19 inside his body. Before their eyes, they get a hint of what might be to come in the pandemic. wnycstudios.org/podcasts/radio…

3. COVID Variants May Arise in People with Compromised Immune Systems
The case history of a U.K. man in his 70s shows how selective “pressures” bring about viral mutations
scientificamerican.com/article/covid-…

4. SARS-CoV-2 evolution during treatment of chronic infection
nature.com/articles/s4158…

5. High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19
journals.plos.org/plospathogens/…

6. Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host
nejm.org/doi/full/10.10…

7. Patient-derived mutations impact pathogenicity of SARS-CoV-2
medrxiv.org/content/10.110…

8. Understanding COVID-19 and Seasonal Influenza as Quasispecies Mutant Swarms Reveals the Quantum Origins and Cryptic Fates of Human Pandemic harvard2thebighouse.substack.com/p/understandin…

9. Part II: Understanding COVID-19 and Seasonal Influenza as Quasispecies Mutant Swarms Reveals the Quantum Origins and Cryptic Fates of Human Pandemics
harvard2thebighouse.substack.com/p/part-ii-unde…

10. Quasispecies Made Simple ncbi.nlm.nih.gov/pmc/articles/P…

11. Viral Quasispecies Evolution
ncbi.nlm.nih.gov/pmc/articles/P…

Viral quasispecies (2019)
journals.plos.org/plosgenetics/a…

13. Eddie Holmes trying to debunk everything as usual
Evidence for the Non-quasispecies Evolution of RNA Viruses
academic.oup.com/mbe/article/18…
Is the Quasispecies Concept Relevant to RNA Viruses?
(Can you imagine him saying that in a petulant nasal tone?)
ncbi.nlm.nih.gov/pmc/articles/P…