Some people are wondering, with some scientists expressing opposing views about the possiblity of a lab leak in COVID19 origins, how do they know who to trust? In this thread I describe how to recognize the rhetorical devices or fallacies used to push weakly supported views.
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First some background. Scientists face the situation of figuring out the steps that lead to an outcome all the time. For example it’s what molecular biologists do on a daily basis to work out the molecular reactions that underlie initially mysterious biological events.
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We start by brainstorming all the possible hypotheses that are consistent with the known outcome *the more the better* to makes sure we don't miss the right answer. Then we gather data that can help rule out one hypothesis or not.
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Some data could favor one hypothesis over others, but we don’t rule out high-impact hypotheses generally based on a preponderance of data or likelihood. As long as it can still fit the observations, a hypothesis remains in play. The reliability of data must also be weighed.
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In the lab, we can do experiments to gather those data. For COVID19 origins, we (as in humans) can also gather data, if we wanted to. The most relevant to discerning whether SARSCoV2 was passed without or with lab involvement (100% natural vs lab leak), are as follows:
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1. additional virus sampling from the Mojiang mine and caves in Yunnan
2. logs of bat swab specimens collected and viruses cultured and samples disposed by WIV
3. full descriptions and logs of the SARSCoV2 antibody tests performed on WIV staff
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4. hospital records and interviews of HCWs treating the WIV workers hospitalized with flu-like illnesses in November 2019
5. results of virus testing in animals in Wuhan and Yunnan

These data are obtainable but all we have now is the last one, and the results are negative.
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So this is a solvable problem, should PR China wish to provide the data needed to solve it. But right now, it is not solvable with the existing data.
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So given this background, how do you know which scientists to trust, when some say we can already rule out lab leak and others say we cannot rule it out? You can look at the quality of the arguments. If the arguments made are low in quality, the position is weak.
9/🧵
And some low-quality types of arguments are the following:

1. ad hominem attacks, e.g. calling a questioner names like disgraced or discredited rather than addressing the question

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2. appeal to authority, e.g. “I’m an expert and you’re not” or “this other person who is famous backs me up” without analyzing the logic of their positions

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3. circular reasoning, e.g. Dr. A saying “My position X is backed up by other scientists such as Dr. B and C” but when you ask Drs. B and C, they say “According to Dr. A, and he says it’s X”

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4. straw-man argument, or conflation of opposing arguments, e.g. “Proponents of lab leak say the virus was deliberately engineered, so if we conclude it is not, then all kinds of lab leak can be rejected.”

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5. absence of evidence arguments, e.g. “There’s no evidence of lab leak”. This one especially gets me because the whole point of brainstorming hypotheses is to create ideas to investigate in the absence of evidence.

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6. false non-equivalence, e.g. “There’s no direct evidence of lab leak, so it shouldn’t be considered. On the other hand, we think a route from cave/mine to city via food animals is more likely, even though there’s no evidence of that either.”

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7. appeal to emotion, e.g. “We shouldn’t investigate this question because it would insult someone who is a decent person.”

8. appeal to politics, e.g. “We shouldn’t investigate this question because it would strengthen the political opposition”

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Of these, I think appeal to politics is the most harmful, because rather than even trying to appeal to some common element of humanity, the speaker is trying to appeal to the listener's political desires, which by definition means pushing one group's interest above others'.
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And these fallacies can be combined, e.g. “There’s no evidence of lab leak, so we shouldn’t demand the evidence either” combines lack of evidence + circular reasoning.
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Or “Proponents of lab leak say the virus was deliberately engineered, but there is no evidence of that” combines straw-man plus lack of evidence arguments.
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Or “We shouldn’t investigate this person because it would insult someone decent who didn’t do anything wrong” combines appeal to emotion + circular reasoning/
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Sometimes you can see multiple fallacies in just one article, for example the one @kundan_official astutely analyzed below. It's a valuable lesson in that you need to be use critical thinking about things you read even in brand-name websites.
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It also shows, as did @Ayjchan multiple times, that you don't have to be someone who has led multimillion-dollar efforts on isolating viruses in China, or a writer for a well known publication, to make logical arguments and refute illogical ones.
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So when someone with a PhD says their scientific opinion is something, but then use the fallacies above to push their position or to attack those who don’t agree with them, they are no longer engaging in a scientific discussion.
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On the other hand, a PhD acting as a real scientist will assess the situation in terms of how much we know and how much we still need to know. That is, they will point out a scientific investigation has stages, and describe the degree of certainty possible at this time.
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So for readers who want to know whose *scientific* opinion to trust, rather than whose *political* opinion to cheer, just look for those telltale signs above. They are signs not of strength for their position, but of weakness.
🧵/🧵
(aka double-standard fallacy)

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More from @michaelzlin

23 May
Was just thinking that the CRISPR baby episode foreshadowed many of the issues were now grappling with on SARSCoV2 origins. And then because it can read my mind, my news feed told me that my colleague Hank Greeley has a book out about it this week. irishtimes.com/news/science/c…
What are the similarities?
- A controversial line of investigation because of its potential for harm
- A high-visibility topic, so some fame to those who navigate safety and ethics properly
- Chinese scientists eager to show they are as technically capable as Western scientists
Now we don't know where SARSCoV2 came from, so there could be no involvement of Chinese scientists. But in both cases, the central PR China government has squelched the release of certain records that, if everything was done properly, would have exonerated the people involved.
Read 11 tweets
22 May
For those following the less-perfect vaccines (what most of the world will get), a medrxiv study from Chile this week provides some very valuable data: neutralizing antibody levels after natural infection vs 1 or 2 doses inactivated virus or RNA vax. medrxiv.org/content/10.110…
Most interesting finding: Similar nAb titers after natural infection vs. uninfected after 2 doses CoronaVac or after 1 dose BNT162b2 (Pfizer/BioNTech). These are columns 1, 6, and 8 in the below chart.

What does it mean?
Several things:
1. The data are in line with Coronavac Phase 1/2 trials. There, nAb levels after 2 doses 4 weeks apart reached ~0.6x of convalescent sera. Here the graph shows nAb levels after 2 doses > convalescent sera, but the text says a bit less (1595 vs 1860, not sure why)
Read 11 tweets
22 May
Like others, I admire Fauci for being a straight and clear talker.

It's big news then that, at 13:00 below, he says we can't rule out lab involvement in COVID19 origins. That completely blows up claims by certain people that no serious scientists could consider that.

His words:
"No I’m not convinced about that [natural origin]. I think that we should continue to investigate what went on in China until we find out to the best of our ability exactly what happened.”
"Certainly the people who’ve investigated it say that it likely was the emergence from an animal reservoir that then infected individuals but it could have been something else, and we need to find it out."
Read 5 tweets
1 Apr
🧵A year into COVID19, despite the heroic efforts of many, our regulatory and medical systems have clearly NOT adapted adequately.

Here's an infuriating look at how pre-pandemic SOPs are preventing patients from getting life-saving treatment.
nytimes.com/2021/03/31/opi…
2) "Because mAb treatment can be administered only in an outpatient setting ... in one case I had to persuade the admitting team to discharge a patient from the hospital so that they could send him to the emergency room to receive the care he needed." This is absurd.
3) Why does it happen? It's what I'd call the tyranny of the drug label. FDA approved this particular mAb treatment for outpatient use, and apparently no doctor at this hospital could be persuaded to use it off-label for inpatient use, even though the drug will definitely work.
Read 14 tweets
17 Jan
Fellow academics, when are we going to start fixing our urgent structural problems that strain family bonds and present ongoing barriers to diversifying our educational and scientific leadership? You wonder, what the heck is this guy talking about?
1/n
We’re all very familiar what I am talking about, actually: the impossibility for most academics in the life sciences to do their jobs in a reaonable amount of time, due to more and more demands on writing grants, and to a lesser degree, papers.
2/n
As of yesterday I hadn’t intended to write about this subject, but was wondering as I finished a Saturday of straight work, what happened to all my time? Why has WFH not reduced my pile of tasks to do? Instead why is my to-do list growing bigger and bigger?
3/n
Read 25 tweets
25 Dec 20
Here's a Christmas gift: Turkey says Sinovac's COVID vaccine is 91.25% effective. That's a prelim result based on <30 cases but it adds to an earlier announcement from Brazil of >50% efficacy.

This vaccine is an inactivated virus. That's interesting...

reut.rs/37MIOIr
Inactivated virus (aka whole-killed virus or WKV) is the oldest recipe in the vaccine cookbook. The 1st polio (Salk) and flu vaccines work this way. You kill the virus with chemicals, mix with adjuvant, and inject. APCs process and present viral antigens to activate B cells.
In early versions of my #coronadeck I suggested the CDC organize the production of a WKV vacccine. It's very simple and requires no new technology. So why did we not do it? There was a scientific reason but also economic/political reasons.
Read 27 tweets

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