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Hilda Bastian, PhD Profile picture
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28 May, 4 tweets, 2 min read
A government report on Covid vaccination is out from Uruguay gub.uy/ministerio-sal… HT @sgdambrauskas
First, some perspective on the wave Uruguay is struggling with: here's a chart Our World in Data, per million population...1/n
...45.8% of the population had at least one dose of Covid vax as of May 25, mostly Sinovac's CoronaVac & some BNT-Pfizer; 28% of the population has had 2 doses. (The population of Uruguay is about 3.5million)...2/n
...People vaxed with BNT-Pfizer seem to be older, higher risk. Efficacy data are raw, not taking differences into account:
- CoronaVac: 57% against confirmed Covid-19, 95% against needing intensive care
- BNT-Pfizer: 75% against confirmed Covid-19, 99% against intensive care..3/n
...Numbers of people who received both doses of vax at least 14 days before the analysis:
- CoronaVac: 712,716 (Intensive care for Covid: 19; deaths: 6)
- BNT-Pfizer: 149,329 (Intensive care: 1; deaths: 8, all aged 80 or over)
Rates of Covid, intensive care, death vs unvaxed 4/4

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More from @hildabast

Hilda Bastian, PhD Profile picture
27 May
#tbt This is the graduating class of 1915, chemistry division, Tohoku Imperial University. There, at the end of the 2nd row, is the first woman to achieve a bachelor of science in Japan. Her name was 黒田チカ, Chika Kuroda (1884-1968) & she was the daughter of a samurai...1/5
...Kuroda was an organic chemist & studied natural pigments. As an undergraduate, she studied a purple one, Lithospermum erythrorhizon. When she presented her work on it to the Chemical Society of Japan, she was the first woman to ever do that, too ...2/5
en.wikipedia.org/wiki/Chika_Kur…
..Kuroda studied at Oxford Uni 1921-23, & later joined the RIKEN in Japan, where she determined the molecular structure of shikonin, that purple pigment & then of carthamin. It gives safflower its color: she earned her doctorate with that in 1929..3/5 riken.jp/en/about/histo…
Read 5 tweets
Hilda Bastian, PhD Profile picture
26 May
The #4Humanity phase 3 trial of Sinopharm's Beijing & Wuhan vaccines published in JAMA by @NawalAlKaabi &co jamanetwork.com/journals/jama/… HT @swiftshoes

WIV04 = Wuhan: efficacy 14 days+ after dose 2, 72.8% (58-82)
HB02 = Beijing: 78.1% (65-86)
Control group was vax adjuvant ...1/n Image
...Wuhan vax 12,743; Beijing 12,726; control 12,737. Just under 16% were women, <2% were aged 60 & over

Primary efficacy outcome (in tweet 1) was symptomatic Covid-19: 26 in Wuhan group, 21 in Beijing, 95 in control.

Severe Covid-19: 0 in vaxed groups, 2 in control group ...2/n
...The trial protocol and statistical analysis plan are included as supplements
Protocol: cdn.jamanetwork.com/ama/content_pu…
SAP: https://t.co/O67m8Nf7Tn
...3/n
Read 13 tweets
Hilda Bastian, PhD Profile picture
23 May
Public Health England estimate of vax effectiveness against B.1.617.2 variant: they're not reporting vaxes separately yet. Combined data: 1 dose doesn't reach minimum effectiveness level; 2 doses it's reduced, but still high...1/2 HT @statsepi @kallmemeg assets.publishing.service.gov.uk/government/upl…
...They have moderate degree of certainty in conclusion from data on 1 dose, low for 2-dose. Based on the neutralization activity they see in lab tests, "expected to remain effective against severe disease". They don't say when data will be released. 2/2 assets.publishing.service.gov.uk/government/upl…
...PS: From Public Health England preprint on vax effectiveness against B.1.617.2 variant of concern, includes data on "UK" & the new variant. Based on results of 12,675: 11,621 with B.1.1.7 & 1,054 had B.1.617.2...3/n khub.net/documents/1359… HT @dylanhmorris
Read 9 tweets
Hilda Bastian, PhD Profile picture
21 May
UK phase 3 trial of Novavax vax preprint. Later data than January press release with 62 cases of Covid-19. Now 106. Vaccine efficacy:

- Against original strain: 96.4% (74 to 99.5)
- Against B.1.1.7 ("UK") strain: 86.3% (71-94)
- Total 89.7% (80-95)

..1/n
medrxiv.org/content/10.110…
...Symptomatic Covid-19 for primary endpoint (from 7 days after 2nd dose in people with no previous infection): target number for final analysis was 100.

From 14,039 people:
- 10 cases in vax vs 96 placebo;
- 0 severe illness in vax vs 5 in placebo;
- 0 deaths

...2/n
...The people in the trial were:
- 48% female
- 94.5% White
- 2.9% Asian
- 0.4% Black or African American
- 45% had a co-morbidity
...3/n
Read 10 tweets
Hilda Bastian, PhD Profile picture
20 May
Preprint of results for Sinovac CoronaVac phase 1/2 trial in 3-17 year-olds: 72 in phase 1, 480 in phase 2. They tested half & full doses, & immune responses were higher than they are in adults, with a very low rate of adverse reactions ...1/n papers.ssrn.com/sol3/papers.cf…
...Firstly, it's clear why they have gone on to do another large study in under-18s (clinicaltrials.gov/ct2/show/NCT04…). The children were all Han ethnicity & they want to test in other parts of the country to get more diversity...2/n
...Although their results suggest for very small children, half-dose might have been enough, it didn't seem to reduce adverse reactions. That's presumably why the next trial is only full dose...3/4
Read 4 tweets
Hilda Bastian, PhD Profile picture
18 May
Preliminary results of CombiVacS, the Spanish phase 2 trial of BNT-Pfizer vax at least 8 weeks after AZ announced: major boost in neutralizing antibodies - more than in other studies of 2 doses of AZ - without a higher rate of adverse reactions ...1/n english.elpais.com/society/2021-0…
...The results from @SaludISCIII are here isciii.es/Noticias/Notic…

Trial register record is here: clinicaltrials.gov/ct2/show/NCT04…

They're reporting immediately after Data Monitoring Board so people can get their 2nd shots ASAP - control group will now be getting a BNT-Pfizer shot...2/n
... 441 people under the age of 60 got a shot of BNT-Pfizer vaccine; the control group of 232 people had no intervention (no vax or placebo). They reported neutralizing antibodies 14 days after the shot, adverse reactions in 1st 7 days. T-cell data not yet reported ...3/n
Read 8 tweets

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