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Vipin M. Vashishtha Profile picture
@vipintukur
Jun 4, 2021 • 6 tweets • 5 min read • Read on X
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How did #India fare? The graphic tells the whole story:
➡️Brutal onslaught by #B16172: having the highest transmissibility & most immune evader of all VOCs with higher virulence?
➡️No support from Vaccination (negligible coverage & high breakthrough, but reinfections rare) 1/
➡️ Social mitigation measures worked! Or the virus ran out of steam? Or still too early to conclude?
➡️ India struggled (significant mortality/health infrastructure collapsed) but survived!! 2/
New study on immune escape potential of #B16172 in comparison to #B1351 w/ #BNT162b2 vaccine: More immune evader than even B1351 VOC! Significant loss of antibody neutralisation vs live B16172 (-5.8x, akin to B.1.351) @TheLancet 3/
thelancet.com/journals/lance…
Increased age & time since 2nd dose correlated with reduced virus neutralisation across all strains. Not unusual, but given low starting titres vs #B16172, more of a concern to see neutralisation “dropping off”, significantly. Boosters may be needed!! 4/
…………starting from a lower titre (#B16172) means small changes in NAbs titre now likely to have larger effect on vaccine efficacy! 5/
More on immune escape with #B16172 & other VOCs by @DavidLVBauer 👇 6/

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More from @vipintukur

Vipin M. Vashishtha Profile picture
Jun 30
What causes #LongCOVID?

➡️ A new study finds that antibodies from people with the debilitating condition trigger similar symptoms in mice. 1/ Image
Researchers show that antibodies isolated from people with longCOVID increase pain sensitivity and reduce movement in mice when transferred to the animals. 2/

biorxiv.org/content/10.110…

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The findings suggest that antibodies might drive some symptoms of longCOVID — although how that process works is unclear, and the results will need to be replicated in larger studies. 3/ Image
Read 10 tweets
Vipin M. Vashishtha Profile picture
Jun 27
While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure.

A NEW research now has found a way to turn back time and restore the liver. 1/ Image
In experiments using mice and liver tissue from humans, the researchers identified how the aging process prompts certain liver cells to die off. They were then able to reverse the process in the animals with an investigational drug. 2/ Image
These findings hold high promise for the millions of people who have some degree of liver damage—livers that are essentially old due to the metabolic stresses of high cholesterol, obesity, diabetes or other factors. 3/ Image
Read 13 tweets
Vipin M. Vashishtha Profile picture
Jun 26
When symptoms arise, so do questions: When should I test? How accurate is it really? And what should I do if I test positive?

➡️ Researchers unveil a new model to quickly answer such questions, not only for COVID but also for emerging rapid tests for RSV, flu & other bugs 1/ Image
Advice differ widely depending on the bug

➡️ For COVID, if you only have one test, it's best to wait 2 days after symptoms arise to use it, as the virus is unlikely to be detectable until then. For flu & RSV, it is best to take rapid test when you first feel symptoms 2/ Image
We must realise that COVID has changed, each variant behaves differently and that means the way that they interact with tests may be different. 3/ Image
Read 11 tweets
Vipin M. Vashishtha Profile picture
Jun 22
What causes food allergies to develop? There's compelling evidence that suggests imbalances of the gut microbiome could be to blame, creating inflammation of the intestinal tract and a gut environment that's prone to food allergies. 1/ Image
Depletion of beneficial microbes by modern lifestyle factors correlates with the rising prevalence of food allergies. Re-introduction of allergy-protective bacteria may be an effective treatment strategy. 2/ Image
A NEW study reveals a mutually beneficial relationship between an unassuming microbial species & prebiotic lactulose—together, they encourage production of an important metabolite known for its positive influence on gut health, #butyrate, generated as bacteria feed in gut 3/ Image
Read 15 tweets
Vipin M. Vashishtha Profile picture
Jun 21
A NEW study finds sex-specific immune dysregulation contributes to the pathogenesis of #LongCovid (LC)

Several sex-specific immune pathways were found associated w/ LC.

Males show increased TGF-β signaling, while females exhibit higher XIST expression & IL1 signaling 1/ Image
Females who would develop LC demonstrated increased expression of XIST, an RNA gene implicated in autoimmunity, and increased IL1 signaling in monocytes at 12 months post infection. Several immune features of LC were also conserved across sexes. 2/ Image
Both males and females with LC had reduced co-stimulatory signaling from monocytes and broad upregulation of NF-κB transcription factors. 3/ Image
Read 9 tweets
Vipin M. Vashishtha Profile picture
Jun 20
Researchers have successfully reversed the symptoms of Alzheimer's disease in mice!

➡️ They achieved this with a small, synthetic peptide, #PHDP5, that can easily cross the blood-brain barrier to directly target the memory center in the brain. 1/ Image
Curing or delaying the debilitating symptoms of Alzheimer's is extraordinarily difficult due to the elusive nature of the disease. 2/ Image
The exact cause is unknown, and likely involves multiple factors from genetics to lifestyle, and due to the progressive nature of the condition, it is often too late to treat effectively once the symptoms begin to impact daily life. 3/ Image
Read 12 tweets

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