Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Vipin M. Vashishtha Profile picture
@vipintukur
Jun 4, 2021 • 6 tweets • 5 min read • Read on X
Scrolly
How did #India fare? The graphic tells the whole story:
➡️Brutal onslaught by #B16172: having the highest transmissibility & most immune evader of all VOCs with higher virulence?
➡️No support from Vaccination (negligible coverage & high breakthrough, but reinfections rare) 1/
➡️ Social mitigation measures worked! Or the virus ran out of steam? Or still too early to conclude?
➡️ India struggled (significant mortality/health infrastructure collapsed) but survived!! 2/
New study on immune escape potential of #B16172 in comparison to #B1351 w/ #BNT162b2 vaccine: More immune evader than even B1351 VOC! Significant loss of antibody neutralisation vs live B16172 (-5.8x, akin to B.1.351) @TheLancet 3/
thelancet.com/journals/lance…
Increased age & time since 2nd dose correlated with reduced virus neutralisation across all strains. Not unusual, but given low starting titres vs #B16172, more of a concern to see neutralisation “dropping off”, significantly. Boosters may be needed!! 4/
…………starting from a lower titre (#B16172) means small changes in NAbs titre now likely to have larger effect on vaccine efficacy! 5/
More on immune escape with #B16172 & other VOCs by @DavidLVBauer 👇 6/

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Vipin M. Vashishtha

Vipin M. Vashishtha Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @vipintukur

Vipin M. Vashishtha Profile picture
Jan 2
Wow!

Pupil size in sleep reveals how memories are processed!

Researchers have found that the pupil is key to understanding how, and when, the brain forms strong, long-lasting memories. 1/ Image
By studying mice equipped w/ brain electrodes & tiny eye-tracking cameras, researchers find that new memories are being replayed & consolidated when pupil is contracted during a substage of non-REM sleep. When the pupil is dilated, the process repeats for older memories. 2/ Image
The brain's ability to separate these two substages of sleep with a previously unknown micro-structure is what prevents "catastrophic forgetting" in which the consolidation of one memory wipes out another one. 3/ Image
Read 11 tweets
Vipin M. Vashishtha Profile picture
Dec 29, 2024
Impact of COVID-19 on accelerating of immunosenescence & brain aging

The pandemic has highlighted a complex interplay between viral infection, immune aging & brain health, that can potentially accelerate neuroimmune aging & contribute to persistence of long COVID condition 1/ Image
By inducing chronic inflammation, immunosenescence, and neuroinflammation, COVID-19 may exacerbate the processes of neuroimmune aging, leading to increased risks of cognitive decline, neurodegenerative diseases, and impaired immune function. 2/ Image
Both aging & COVID-19 can induce neuroinflammation through the accumulation of senescent cells, persistent microglia and astrocytes’ activation, and increased pro-inflammatory cytokine production, such as IL-1β, IL-6, and TNF-α. 3/ Image
Read 6 tweets
Vipin M. Vashishtha Profile picture
Dec 27, 2024
COVID pregnancies may have boosted autism risk!

A NEW study shows the onset of autism in COVID exposed babies at 28 months. Researchers found 23 of 211 children (11%), screened positive for autism spectrum disorder, compared with an expected prevalence of 1-2% at that age 1/ Image
When researchers analyzed videos of children lying on their backs in what’s called General Movement Assessment, 14% of infants showed signs of developmental problems. The test evaluates early motor functions & is often used to assess the risk of neurodevelopmental disorders 2/ Image
Later, the findings proved equally troubling. At 6-8 months old, 13 of 109 infants born to infected mothers — almost 12% — had failed to reach developmental milestones. In stark contrast, all infants in a control group born before the pandemic showed normal development. 3/
Read 10 tweets
Vipin M. Vashishtha Profile picture
Dec 27, 2024
Researchers have identified interleukin-23 receptor (IL-23R) as a significant biomarker of cellular senescence and aging. Experiments show that IL-23R levels in the bloodstream increase with age and can decrease, reflecting senescent cell clearing, with senolytic therapies. 1/ Image
Cellular senescence occurs when cells stop dividing but do not trigger apoptosis mechanisms that would allow them to die naturally. 2/ Image
Instead, they are stuck in a zombie-like state, where they still have the urge to feed and carry out metabolic activities, but with increasingly incoherent cell signaling and increased pro-inflammatory cytokine secretions. 3/ Image
Read 12 tweets
Vipin M. Vashishtha Profile picture
Dec 26, 2024
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses!

A novel vaccine platform that improved protection against diverse influenza subtypes when tested in animal models and human organoids. 1/ Image
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined.

However, most individuals exhibit a more robust response to one of these strains and thus are vulnerable to infection by others. 2/ Image
By studying a monozygotic twin cohort, the researchers found that although prior exposure was a factor, host genetics were a stronger driver of subtype bias to influenza viral strains. 3/ Image
Read 5 tweets
Vipin M. Vashishtha Profile picture
Dec 24, 2024
Clinical evidence suggests that SARS-CoV-2 directly disrupts vascular homeostasis, with perfusion abnormalities observed in various tissues. The pancreatic islet, a key endocrine mini-organ reliant on its microvasculature for optimal function, may be particularly vulnerable. 1/ Image
Studies have proposed a link between SARS-CoV-2 infection and islet dysfunction, but the mechanisms remain unclear.

Here, researchers investigated how SARS-CoV-2 spike S1 protein affects human islet microvascular function. 2/ Image
Using confocal microscopy and living pancreas slices from non-diabetic organ donors, they show that a SARS-CoV-2 spike S1 recombinant protein activates pericytes — key regulators of islet capillary diameter and beta cell function—and induces capillary constriction. 3/ Image
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(