Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Vipin M. Vashishtha Profile picture
@vipintukur
Jun 4, 2021 • 6 tweets • 5 min read • Read on X
Scrolly
How did #India fare? The graphic tells the whole story:
➡️Brutal onslaught by #B16172: having the highest transmissibility & most immune evader of all VOCs with higher virulence?
➡️No support from Vaccination (negligible coverage & high breakthrough, but reinfections rare) 1/
➡️ Social mitigation measures worked! Or the virus ran out of steam? Or still too early to conclude?
➡️ India struggled (significant mortality/health infrastructure collapsed) but survived!! 2/
New study on immune escape potential of #B16172 in comparison to #B1351 w/ #BNT162b2 vaccine: More immune evader than even B1351 VOC! Significant loss of antibody neutralisation vs live B16172 (-5.8x, akin to B.1.351) @TheLancet 3/
thelancet.com/journals/lance…
Increased age & time since 2nd dose correlated with reduced virus neutralisation across all strains. Not unusual, but given low starting titres vs #B16172, more of a concern to see neutralisation “dropping off”, significantly. Boosters may be needed!! 4/
…………starting from a lower titre (#B16172) means small changes in NAbs titre now likely to have larger effect on vaccine efficacy! 5/
More on immune escape with #B16172 & other VOCs by @DavidLVBauer 👇 6/

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Vipin M. Vashishtha

Vipin M. Vashishtha Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @vipintukur

Vipin M. Vashishtha Profile picture
May 5
A new study shows that coronavirus spike proteins can trigger mast cell degranulation by binding to cellular receptors and activating the Src/PI3K/AKT signaling pathway, leading to increased calcium levels and mast cell granule release. 1/ Image
The activation and degranulation of mast cells (MCs), triggered by a variety of viruses, are intricately linked to viral pathogenesis. However, the precise mechanism underlying virus-induced MC degranulation remains largely unknown. 2/ Image
In this study, researchers demonstrate the ubiquity of coronavirus-induced MC degranulation and investigate the intracellular signaling pathways that mediate this process. 3/ Image
Read 7 tweets
Vipin M. Vashishtha Profile picture
May 5
Tiny RNA molecule may hold the key to treating knee osteoarthritis!

A NEW discovery could pave the way for new breakthroughs in detecting & treating the disease. Researchers identified a circulating microRNA, miR-126-3p, a mechanistic biomarker of osteoarthritis of knee 1/ Image
MiR-126-3p plays a role in reducing blood vessel formation and reducing the severity of knee osteoarthritis, making it not just a signal of disease—but potentially a contributor to it. 2/ Image
Now that scientists are aware of miR-126-3p, they can develop blood tests to detect osteoarthritis of the knee and therapeutics for slowing or even stopping progression. 3/ Image
Read 6 tweets
Vipin M. Vashishtha Profile picture
Apr 30
A new preprint validated earlier findings that genetic factors strongly influence who develops Long COVID, using data from both U.S. (All of Us) and U.K. (Sano GOLD) cohorts with diverse ancestries. 1/ Image
Over 90% of genes identified in the original study were also associated with #LongCOVID in the U.S. population including in Black and Hispanic groups. 2/
These results confirm that combinatorial genetic analysis can uncover more risk genes than traditional Genome-wide association studies (GWAS) and support the continued exploration of drug repurposing candidates for LongCOVID treatment. 3/ Image
Read 6 tweets
Vipin M. Vashishtha Profile picture
Apr 30
A team of researchers has launched a global clinical trial to evaluate two repurposed anti-inflammatory drugs #upadacitinib and #pirfenidone—approved for treating arthritis and lung disease, respectively as potential treatments for #LongCOVID. 1/ Image
he two drugs were selected using artificial intelligence (AI) from over 5,400 proteins linked to LongCOVID, offering a promising shortcut to treatment by targeting 13 shared biological pathways.  2/ Image
Despite the global prevalence of longCOVID, patients report different symptoms & their presentation can be influenced by where they happen to live. 3/ Image
Read 4 tweets
Vipin M. Vashishtha Profile picture
Apr 29
A group from SUNY Buffalo developed a nanoparticle vaccine candidate that displays recombinant H5 and N1 proteins from the highly pathogenic avian influenza H5N1 clade 2.3.4.4b on liposomes. 1/ Image
The widespread transmission of highly pathogenic avian H5N1 influenza, clade 2.3.4.4b, in wild and livestock mammals with isolated human cases has heightened concerns for zoonotic outbreak, necessitating vaccine readiness. 2/ Image
Here, the researchers assess whether recombinant H5 hemagglutinin and N1 neuraminidase proteins can confer protection from disease when antigens are presented as an adjuvanted nanoparticle vaccine. 3/ Image
Read 7 tweets
Vipin M. Vashishtha Profile picture
Apr 29
Children who tested positive for COVID, face significantly higher long-term risks for chronic kidney disease, gastrointestinal disorders, and cardiovascular issues compared to peers who tested negative. 1/ Image
The study, led by the University of Pennsylvania and part of the NIH’s RECOVER initiative, found kidney disease risks increased up to 35%, GI symptoms by up to 28%, and cardiovascular conditions like heart inflammation or arrhythmias by 63%. 2/ Image
Racial differences also emerged with Asian American Pacific Islander children showing slightly higher LongCOVID risk.  3/
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(