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Vipin M. Vashishtha

@vipintukur

Mar 12

What causes MIS-C in children?

Researchers have identified that reactivation of a pre-existing, dormant infection with the Epstein-Barr virus (EBV) triggers an excessive inflammatory response. 1/

They establish a connection between SARS-CoV-2 infection and COVID-19 sequelae in children, in which impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation. 2/

MIS-C is a serious inflammatory shock that affects children. It can occur several weeks after a COVID infection and can be life-threatening. Until now, however, the precise cause of the condition was unknown. 3/

Read 19 tweets

Vipin M. Vashishtha

@vipintukur

Mar 12

According to a NEW study, among 289 million adults in 18 European countries, more than 16 million years of life were lost from 2020 through 2022 due to the COVID-19 pandemic. 1/

Many people who died during the pandemic would likely have lived longer if the pandemic had not happened.More than half of the total years of life lost would have been lived without disability & independently if the pandemic had been avoided, even among people aged over 80. 2/

About 2.3 million years of life were lost in the UK, a similar number in Germany, 3.2 million in Spain, 2.5 million in Poland, 1.8 million in Italy, and 1.1 million years of life were lost in France. 3/

Read 8 tweets

Vipin M. Vashishtha

@vipintukur

Mar 4

A NEW study finds that staying away from smartphones can even change one's brain chemistry. Brain scans showed significant activity shifts in reward & craving regions of the brain, resembling patterns seen in substance or alcohol addiction. 1/

A smartphone's glow is often the first and last thing we see as we wake up in the morning and go to sleep at the end of the day. It is increasingly becoming an extension of our body that we struggle to part with. 2/

The researchers recruited young adults for a 72-hour smartphone restriction diet where they were asked to limit smartphone use to essential tasks such as work, daily activities, and communication with their family or significant others. 3/

Read 13 tweets

Vipin M. Vashishtha

@vipintukur

Mar 2

A NEW study revealed previously unrecognized complement dysregulation associated with impaired cell death and clearance of damaged cells, which may promote nonresolvable (NR) COVID-19 in patients, ultimately necessitating lung transplantation. 1/

Researchers analyzed complement activation in NR-COVID-19 lungs and its association with aberrant host autophagic response. It is the first study to comprehensively show the local presence of the components of the three pathways and regulators of complement activation 2/

The researchers are also the first to investigate the involvement of autophagic mediators as a potential mechanism underlying dysregulated complement-induced tissue damage leading to end-stage respiratory failure. 3/

Read 12 tweets

Vipin M. Vashishtha

@vipintukur

Feb 28

How to protect the gut from antibiotics!

Antibiotics save lives, but they also wreak havoc on the beneficial bacteria that inhabit the human gut. Innovative therapies could shield the microbiome from their effects. 1/

Researchers have genetically engineered bacteria and nutritional yeast to carry an enzyme that breaks down amoxicillin in the gut without affecting the antibiotic’s ability to fight infection elsewhere in the body. 2/

Other scientists have found that high- fibre diets allay antibiotics’ effects on the gut by changing how intestinal microbes metabolize nutrients. 3/

Read 23 tweets

Vipin M. Vashishtha

@vipintukur

Feb 27

A NEW study showed that kids with #LongCOVID had lung injuries that correlated to specific LongCOVID symptoms and overall loss of blood flow in the lungs. In participants with longCOVID, greater lung perfusion correlated with increased chronic fatigue severity. 1/

Children and teens with #LongCOVID have significant lung abnormalities detected with an advanced form of MRI, called free-breathing phase-resolved functional lung (PREFUL) MRI. 2/

Children with post-COVID-19 symptoms are less likely to undergo chest scans for diagnosis and lung function monitoring than adults with LongCOVID. Lung perfusion, or blood flow in and out of the lungs, is difficult to detect in children. 3/

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