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Vipin M. Vashishtha

@vipintukur

Feb 2

SARS-CoV-2 spike protein is a highly persistent, potentially pathogenic substance that may incite inflammation and tissue damage in almost all organ systems, resulting in #LongCovid a.k.a post-acute sequelae of Covid-19 (PAŚĆ) 1/

Researchers found abundant evidence that SARS-CoV-2 spike protein may cause damage in the cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems. 2/

Viral and vaccine-encoded spike proteins have been shown to play a direct role in cardiovascular and thrombotic injuries from both SARS-CoV-2 and vaccination. 3/

Arterial Thrombi From COVID-19 + Patients Contain SARS-CoV-2 Spike Protein But Not Nucleocapsid Protein👇

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Vipin M. Vashishtha

@vipintukur

Feb 1

Cancer cells hijack T-cells, making it harder for the body to fight back!

Researchers discovered a surprising way cancer evades the immune system. It essentially hacks the immune cells, transferring its own faulty mitochondrial DNA into the T-cells meant to attack it. 1/

This sneaky move weakens the immune cells, making them less effective at stopping the tumor. The findings could help explain why some cancer treatments, like immunotherapy, are effective for some patients but not others. 2/

In the study, the researchers looked at how cancer cells interact with tumor-infiltrating lymphocytes, a type of T-cell that typically fights tumors. Clinical specimens from melanoma & lung cancer patients were analyzed for faulty mitochondrial DNA (mtDNA) mutations. 3/

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Vipin M. Vashishtha

@vipintukur

Jan 31

Researchers found a link between COVID-19 & blood markers linked to faulty proteins in the brain. They found people who had previously had COVID-19 were more likely to have increased levels of biomarkers linked to faulty amyloid proteins—a hallmark for Alzheimer's disease. 1/

On average, the effects were comparable to 4 years of aging with the greatest effects seen in those hospitalized with severe COVID-19 or with underlying risk factors for dementia such as smoking or high blood pressure. 2/

The findings suggest that mild or moderate COVID may accelerate biological processes that contribute to buildup of disease-promoting amyloid in brain. This raises possibility that COVID-19 might contribute to an increase in later risks of developing Alzheimer's disease. 3/

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Vipin M. Vashishtha

@vipintukur

Jan 31

Is scratching good or bad for you?

A new research uncovers how scratching aggravates inflammation & swelling in a mouse model of allergic contact dermatitis.
But, wait, the study finds that scratching also provides defense against bacterial skin infections. 1/

At first, these findings seemed to introduce a paradox: If scratching an itch is bad for us, why does it feel so good?

Scratching is often pleasurable, which suggests that, in order to have evolved, this behavior must provide some kind of benefit. 2/

The study helps resolve the paradox by providing evidence that scratching also provides defense against bacterial skin infection

They used itch-inducing allergens to induce eczema-like symptoms on ears of normal mice & those don't get itchy as they lack itch-sensing neuron 3/

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Vipin M. Vashishtha

@vipintukur

Jan 30

A recent study now finds answer to the query: “Why one spouse or partner is infected & the other remains asymptomatic although both are exposed to SARS-CoV-2 virus!” It is due to elevated expression of the gene IFIT3 (interferon-inducible protein with tetrapeptide repeats 3) 1/

The women who were immune to the virus exhibited elevated expression of the gene IFIT3 (interferon-inducible protein with tetrapeptide repeats 3) compared with their male partners. 2/

Researchers join a study on serodiscordant couples.

Serodiscordant couples are so called because one spouse or partner is infected & the other remains asymptomatic although both are exposed to the virus and do not use any kind of special protection. 3/

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Vipin M. Vashishtha

@vipintukur

Jan 28

Covid may have gone, but has left its indelible footprints on our immune system!

Years later, scientists are still sifting through the data to garner a better understanding of how our immune system dealt with this new virus!

Here are four lessons we’ve learnt so far…1/

1-Antibodies aren’t everything!

Antibodies against SARS-CoV-2 waned in the months after vaccination, but vaccinated people continued to make T cells that recognized the virus. 2/

2-New insight in to how innate immune system works!

Researchers found signs of interferon responses, a key effector of innate system throughout the body, even in organs far away from infected cells. 3/

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