We are now here.
The source from this chart is Figure 2 of the SPI-M-O consensus statement of 12 May, a few days before we moved to Step 3 of the Roadmap.

assets.publishing.service.gov.uk/government/upl…
The figure comes from the Warwick/JUNIPER Road Map scenarios

assets.publishing.service.gov.uk/government/upl…
There is a lot of uncertainty in those models. The 'we are now here' chart above assumes for example that vaccines give complete protection.
PHE have been gathering evidence on the Delta/B.1.617.2/'India' variant.

This is their latest analysis.

There are risks in
- transmissibility
- infection severity
- vaccines, and to a lesser extent
- immunity after natural infection.
There is still uncertainty in these risks, but that uncertainty is narrowing.

A key factor in what may happen is transmissibility.

The Secretary of State for Health and Social care has said that the variant is " around 40% more transmissible"

On Friday, this was estimated at 60% more transmissible (with a range of between 30 and 60% more transmissible)

There is still uncertainty.

We need:
- a consensus statement on the increase in transmissibility
- updated SPI-M modelling based on the newest data
- politicians to make decisions based on Data Not Dates
The Government will apparently make their decision on or around 14 June (a week before the earliest Step 4 date of 21 June)

It is imperative that the Government use the evidence & overcome an optimisim bias, as no-one wants to go into a *fourth* lockdown (of whatever stringency)
Back to the chart

*If* Delta is 40% more transmissibile per Matt Hancock, it could be taken that the Government is working on the basis that the next wave will be lower than the 1st or 2nd peaks (but large)

However, this 40% claim doesn't *appear* (publicly) to be a consensus.
correction: range was estimated on Friday as being between 30% and 100% more transmissible

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More from @Dr_D_Robertson

3 Jun
Cumulative case numbers for variants published by PHE today, 3 June.

I think we all get the picture now that the Delta/B.1.617.2/'India' variant is becoming dominant.

Here are the charts.

And a final tweet linking to today's risk assessment of Delta, which isn't great news.
Logarithmic cumulative chart.
Heatmaps of weekly cases
Read 7 tweets
3 Jun
The PHE risk assessment of Delta/B.1.617.2/'India' has been updated today, 3 June.

- *new* INFECTION SEVERITY risk assessed as RED (with Iow confidence)
- VACCINES risk still assessed as RED but now with HIGH confidence.

Previous versions linked below.

A thread.
TRANSMISSIBILITY BETWEEN HUMANS
RED risk
HIGH confidence

"Transmissibility appears greater than wild type (first wave) SARS-CoV-2Delta continues to demonstrate a substantially increased growth rate compared to Alpha, across multiple analyses. ...
"... Delta cases are rising whilst Alpha cases are declining. Secondary attack rates, including household secondary attack rates, are higher for Delta, but these are not yet corrected for vaccination status. There is in vitro evidence suggestive of increased replication in ...
Read 19 tweets
3 Jun
What is the 'Nepal Variant'?

This is the Transport Secretary's statement just now, justifying why Portugal has moved from the green list of countries.

"a sort of Nepal mutation of the so-called Indian variant which has been detected"
This was featured prominently in today's Daily Mail.
The World Health Organization apparently do not know about it.

Read 7 tweets
3 Jun
The green/amber/red list and the role of the Joint Biosecurity Centre in those risk analyses.

Reminiscent of the JBC work on the CONTAIN framework for deciding which local authorities should be in which tiers.

A short thread.
The JBC is responsible for publishing a risk assessment that is used to determine which countries are on the green, amber, and red lists.

gov.uk/government/spe…
We can *assume* that these risk assessments have been conducted and have informed the reported move of Portugal from the green list to the amber list.

Here is how we are told they are completed

gov.uk/government/pub…
Read 10 tweets
1 Jun
The Government's strategy has always been that, on repoening, cases would increase.

A short thread.
Cases are, indeed, increasing.

There appears to be an approximate constant rate of increase.

However, testing is very much dependent on who is tested and where testing is taking place, surge testing and the like.
The Government's Roadmap has depended on four tests.

None of these tests involve cases (directly).

Read 17 tweets
1 Jun
On the WHO naming (a short thread with some comments on the new naming system.

1. Here it is. Good that it's here but it's far too late
who.int/en/activities/…
2. any scientist would have thought about using the Greek alphabet (because that's what scientists do) but probably discounted it because, well, it's a bit.. Greek (see point 1)
3. it's not future-proof.

10 Greek letters have been used up already out of 24. It's back to the drawing board for variant 25 (or at least another decision has to be made as to which e.g. alphabet to use)
Read 8 tweets

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